Mitochondrial ubiquinol oxidation is necessary for tumour growth.
Martínez-Reyes I, Cardona LR, Kong H, Vasan K, McElroy GS, Werner M, Kihshen H, Reczek CR, Weinberg SE, Gao P, Steinert EM, Piseaux R, Budinger GRS, Chandel NS.
Martínez-Reyes I, et al.
Nature. 2020 Sep;585(7824):288-292. doi: 10.1038/s41586-020-2475-6. Epub 2020 Jul 8.
Nature. 2020.
PMID: 32641834
Free PMC article.
Cancer cells that lack mitochondrial complex III but can regenerate NAD+ by expression of the NADH oxidase from Lactobacillus brevis (LbNOX)(13) targeted to the mitochondria or cytosol were still unable to grow tumours. ...
Cancer cells that lack mitochondrial complex III but can regenerate NAD+ by expression of the NADH oxidase from Lactobacillus brevis …