The prion protein ligand, stress-inducible phosphoprotein 1, regulates amyloid-β oligomer toxicity.
Ostapchenko VG, Beraldo FH, Mohammad AH, Xie YF, Hirata PH, Magalhaes AC, Lamour G, Li H, Maciejewski A, Belrose JC, Teixeira BL, Fahnestock M, Ferreira ST, Cashman NR, Hajj GN, Jackson MF, Choy WY, MacDonald JF, Martins VR, Prado VF, Prado MA.
Ostapchenko VG, et al. Among authors: ferreira st.
J Neurosci. 2013 Oct 16;33(42):16552-64. doi: 10.1523/JNEUROSCI.3214-13.2013.
J Neurosci. 2013.
PMID: 24133259
Free PMC article.
We confirmed the specific binding of AbetaOs and STI1 to the PrP and showed that STI1 efficiently inhibited AbetaO binding to PrP in vitro (IC50 of 70 nm) and also decreased AbetaO binding to cultured mouse primary hippocampal neurons. ...
We confirmed the specific binding of AbetaOs and STI1 to the PrP and showed that STI1 efficiently inhibited AbetaO binding to PrP in vitr …