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Year Number of Results
1984 1
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1987 2
1988 2
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1990 2
1991 2
1992 2
1993 2
1994 2
1995 2
1996 1
1997 2
1998 3
1999 3
2000 1
2001 4
2002 6
2003 5
2004 6
2005 8
2006 11
2007 10
2008 7
2009 13
2010 13
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2012 7
2013 19
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2016 20
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2022 17
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2024 10

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336 results

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Page 1
Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19.
Hammond J, Leister-Tebbe H, Gardner A, Abreu P, Bao W, Wisemandle W, Baniecki M, Hendrick VM, Damle B, Simón-Campos A, Pypstra R, Rusnak JM; EPIC-HR Investigators. Hammond J, et al. N Engl J Med. 2022 Apr 14;386(15):1397-1408. doi: 10.1056/NEJMoa2118542. Epub 2022 Feb 16. N Engl J Med. 2022. PMID: 35172054 Free PMC article. Clinical Trial.
BACKGROUND: Nirmatrelvir is an orally administered severe acute respiratory syndrome coronavirus 2 main protease (M(pro)) inhibitor with potent pan-human-coronavirus activity in vitro. METHODS: We conducted a phase 2-3 double-blind, randomized, controlled trial in which sy …
BACKGROUND: Nirmatrelvir is an orally administered severe acute respiratory syndrome coronavirus 2 main protease (M(pro)) inhibitor with pot …
Variant PNLDC1, Defective piRNA Processing, and Azoospermia.
Nagirnaja L, Mørup N, Nielsen JE, Stakaitis R, Golubickaite I, Oud MS, Winge SB, Carvalho F, Aston KI, Khani F, van der Heijden GW, Marques CJ, Skakkebaek NE, Rajpert-De Meyts E, Schlegel PN, Jørgensen N, Veltman JA, Lopes AM, Conrad DF, Almstrup K. Nagirnaja L, et al. N Engl J Med. 2021 Aug 19;385(8):707-719. doi: 10.1056/NEJMoa2028973. Epub 2021 Aug 4. N Engl J Med. 2021. PMID: 34347949 Free PMC article.
BACKGROUND: P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are short (21 to 35 nucleotides in length) and noncoding and are found almost exclusively in germ cells, where they regulate aberrant expression of transposable elements and postmeiotic gene expres …
BACKGROUND: P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are short (21 to 35 nucleotides in length) and noncoding …
Drug-Drug Interactions Involving Dexamethasone in Clinical Practice: Myth or Reality?
Bourdin V, Bigot W, Vanjak A, Burlacu R, Lopes A, Champion K, Depond A, Amador-Borrero B, Sene D, Comarmond C, Mouly S. Bourdin V, et al. J Clin Med. 2023 Nov 15;12(22):7120. doi: 10.3390/jcm12227120. J Clin Med. 2023. PMID: 38002732 Free PMC article. Review.
Concomitant administration of multiple drugs frequently causes severe pharmacokinetic or pharmacodynamic drug-drug interactions (DDIs) resulting in the possibility of enhanced toxicity and/or treatment failure. The activity of cytochrome P450 (CYP) 3A4 and P-glycoprotein ( …
Concomitant administration of multiple drugs frequently causes severe pharmacokinetic or pharmacodynamic drug-drug interactions (DDIs) resul …
Functional maturation of kidney organoid tubules: PIEZO1-mediated Ca2+ signaling.
Carrisoza-Gaytan R, Kroll KT, Hiratsuka K, Gupta NR, Morizane R, Lewis JA, Satlin LM. Carrisoza-Gaytan R, et al. Am J Physiol Cell Physiol. 2023 Mar 1;324(3):C757-C768. doi: 10.1152/ajpcell.00288.2022. Epub 2023 Feb 6. Am J Physiol Cell Physiol. 2023. PMID: 36745528 Free PMC article.
Nat Methods 16: 255-262, 2019; Takasato M, Er PX, Chiu HS, Maier B, Baillie GJ, Ferguson C, Parton RG, Wolvetang EJ, Roost MS, Chuva de Sousa Lopes SM, Little MH. Nature 526: 564-568, 2015.). However, their physiological function has yet to be systematically investigated. …
Nat Methods 16: 255-262, 2019; Takasato M, Er PX, Chiu HS, Maier B, Baillie GJ, Ferguson C, Parton RG, Wolvetang EJ, Roost MS, Chuva de Sous …
On cytoadhesion of Plasmodium vivax: raison d'être?
Costa FT, Lopes SC, Ferrer M, Leite JA, Martin-Jaular L, Bernabeu M, Nogueira PA, Mourão MP, Fernandez-Becerra C, Lacerda MV, del Portillo H. Costa FT, et al. Mem Inst Oswaldo Cruz. 2011 Aug;106 Suppl 1:79-84. doi: 10.1590/s0074-02762011000900010. Mem Inst Oswaldo Cruz. 2011. PMID: 21881760 Free article. Review.
Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively associated with P. vivax and that P. vivax-infected reticulocytes are able to cytoadhere in vitro to different endothelial cells and placental c …
Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively associated with P. …
Translational Peptide-associated Nanosystems: Promising Role as Cancer Vaccines.
Zupančič E, Peres C, Matos AI, Lopes J, Moreira JN, Gaspar RS, Florindo HF. Zupančič E, et al. Curr Top Med Chem. 2016;16(3):291-313. doi: 10.2174/1568026615666150701115508. Curr Top Med Chem. 2016. PMID: 26126909 Review.
Different classes of nanosystems have been used to protect and deliver several vaccine components. In vitro and preclinical studies have emphasized their promising role to attain a prolonged eradication of cancer cells, including metastasis. ...
Different classes of nanosystems have been used to protect and deliver several vaccine components. In vitro and preclinical studies h …
Apoptosis Transcriptional Profile Induced by Porphyromonas gingivalis HmuY.
Carvalho-Filho PC, Moura-Costa LF, Pimentel ACM, Lopes MPP, Freitas SA, Miranda PM, Costa RS, Figueirêdo CAV, Meyer R, Gomes-Filho IS, Olczak T, Xavier MT, Trindade SC. Carvalho-Filho PC, et al. Mediators Inflamm. 2019 Mar 18;2019:6758159. doi: 10.1155/2019/6758159. eCollection 2019. Mediators Inflamm. 2019. PMID: 31011284 Free PMC article.
This study aimed at evaluating the transcriptional profile of apoptosis-related genes after in vitro stimulation of peripheral blood mononuclear cells (PBMCs) derived from individuals with periodontitis (P) and healthy nonperiodontitis (NP) control subjects with …
This study aimed at evaluating the transcriptional profile of apoptosis-related genes after in vitro stimulation of peripheral blood …
Decreasing Antibiotic Resistance Trends Nationally in Gram-Negative Bacteria Across United States Veterans Affairs Medical Centers, 2011-2020.
Liao JX, Appaneal HJ, Menon A, Lopes V, LaPlante KL, Caffrey AR. Liao JX, et al. Infect Dis Ther. 2023 Jul;12(7):1835-1848. doi: 10.1007/s40121-023-00827-9. Epub 2023 Jun 16. Infect Dis Ther. 2023. PMID: 37326931 Free PMC article.
RESULTS: Among 40 antimicrobial resistance phenotype trends assessed in 494,593 Gram-negative isolates, there were no noted increases; significant decreases were observed in 87.5% (n = 35), including in all P. aeruginosa, Citrobacter, Klebsiella, M. morganii, and S. marces …
RESULTS: Among 40 antimicrobial resistance phenotype trends assessed in 494,593 Gram-negative isolates, there were no noted increases; signi …
Optimization of Plasmodium vivax infection of colonized Amazonian Anopheles darlingi.
Andrade AO, Santos NAC, Bastos AS, Pontual JDC, Araújo CS, Lima AS, Martinez LN, Ferreira AS, Aguiar ACC, Teles CBG, Guido RVC, Santana RA, Lopes SCP, Medeiros JF, Rizopoulos Z, Vinetz JM, Campo B, Lacerda MVG, Araújo MS. Andrade AO, et al. Sci Rep. 2023 Oct 24;13(1):18207. doi: 10.1038/s41598-023-44556-y. Sci Rep. 2023. PMID: 37875508 Free PMC article.
Obtaining Plasmodium vivax sporozoites is essential for in vitro culture of liver stage parasites, not only to understand fundamental aspects of parasite biology, but also for drug and vaccine development. A major impediment to establish high-throughput in vitro …
Obtaining Plasmodium vivax sporozoites is essential for in vitro culture of liver stage parasites, not only to understand fundamental …
Crotalphine Modulates Microglia M1/M2 Phenotypes and Induces Spinal Analgesia Mediated by Opioid-Cannabinoid Systems.
Lopes FSR, Giardini AC, Sant'Anna MB, Kimura LF, Bufalo MC, Vigerelli H, Zambelli VO, Picolo G. Lopes FSR, et al. Int J Mol Sci. 2022 Sep 30;23(19):11571. doi: 10.3390/ijms231911571. Int J Mol Sci. 2022. PMID: 36232883 Free PMC article.
Thus, the central effect of crotalphine was evaluated on the partial sciatic nerve ligation (PSNL)-induced chronic neuropathic pain model. Crotalphine (100 g/kg, p.o.)-induced analgesia on the 14th day after surgery lasting up to 24 h after administration. ...Additionally, …
Thus, the central effect of crotalphine was evaluated on the partial sciatic nerve ligation (PSNL)-induced chronic neuropathic pain model. C …
336 results