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Restoring tumor immunogenicity with dendritic cell reprogramming.
Zimmermannova O, Ferreira AG, Ascic E, Velasco Santiago M, Kurochkin I, Hansen M, Met Ö, Caiado I, Shapiro IE, Michaux J, Humbert M, Soto-Cabrera D, Benonisson H, Silvério-Alves R, Gomez-Jimenez D, Bernardo C, Bauden M, Andersson R, Höglund M, Miharada K, Nakamura Y, Hugues S, Greiff L, Lindstedt M, Rosa FF, Pires CF, Bassani-Sternberg M, Svane IM, Pereira CF. Zimmermannova O, et al. Sci Immunol. 2023 Jul 14;8(85):eadd4817. doi: 10.1126/sciimmunol.add4817. Epub 2023 Jul 7. Sci Immunol. 2023. PMID: 37418548 Free PMC article.
In addition to acquiring improved antigen presentation, tumor-APCs had impaired tumorigenicity in vitro and in vivo. Injection of in vitro generated melanoma-derived tumor-APCs into subcutaneous melanoma tumors delayed tumor growth and increased survival in mice. .. …
In addition to acquiring improved antigen presentation, tumor-APCs had impaired tumorigenicity in vitro and in vivo. Injection of in …
Improved immunogenicity of Newcastle disease virus inactivated vaccine following DNA vaccination using Newcastle disease virus hemagglutinin-neuraminidase and fusion protein genes.
Firouzamandi M, Moeini H, Hosseini D, Bejo MH, Omar AR, Mehrbod P, Ideris A. Firouzamandi M, et al. J Vet Sci. 2016 Mar;17(1):21-6. doi: 10.4142/jvs.2016.17.1.21. Epub 2016 Mar 22. J Vet Sci. 2016. PMID: 27051336 Free PMC article.
The present study describes the development of DNA vaccines using the hemagglutinin-neuraminidase (HN) and fusion (F) genes from AF2240 Newcastle disease virus strain, namely pIRES/HN, pIRES/F and pIRES-F/HN. Transient expression analysis …
The present study describes the development of DNA vaccines using the hemagglutinin-neuraminidase (HN) and fusion (F) genes from AF22 …
Technetium glucose complexes as potential cancer imaging agents.
Dapueto R, Aguiar RB, Moreno M, Machado CM, Marques FL, Gambini JP, Chammas R, Cabral P, Porcal W. Dapueto R, et al. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4254-9. doi: 10.1016/j.bmcl.2015.07.098. Epub 2015 Aug 14. Bioorg Med Chem Lett. 2015. PMID: 26318991
GLUT's (facilitative glucose transporters) over-expression in tumor cells has allowed the detection of several cancer types, using a glucose analogue ((18)F-FDG) with PET images, worldwide. New glucose analogs radiolabeled with (99m)Tc could be a less-expensive and more ac …
GLUT's (facilitative glucose transporters) over-expression in tumor cells has allowed the detection of several cancer types, using a glucose …
The gut microbiome regulates the clinical efficacy of sulfasalazine therapy for IBD-associated spondyloarthritis.
Lima SF, Pires S, Rupert A, Oguntunmibi S, Jin WB, Marderstein A, Funez-dePagnier G, Maldarelli G, Viladomiu M, Putzel G, Yang W, Tran N, Xiang G, Grier A, Guo CJ, Lukin D, Mandl LA, Scherl EJ, Longman RS. Lima SF, et al. Cell Rep Med. 2024 Mar 19;5(3):101431. doi: 10.1016/j.xcrm.2024.101431. Epub 2024 Feb 19. Cell Rep Med. 2024. PMID: 38378002 Free PMC article.
Sulfapyridine promotes butyrate production and transcription of the butyrate synthesis gene but in F. prausnitzii in vitro, which is suppressed by excess folate. Sulfasalazine therapy enhances fecal butyrate production and limits colitis in wild-type and gnotobiotic …
Sulfapyridine promotes butyrate production and transcription of the butyrate synthesis gene but in F. prausnitzii in vitro, wh …
Probiotic, technological, and health-related characteristics of lactobacilli isolated from breast milk.
Pires V, Ribeiro SC, Silva SPM, Juraskova D, Silva CCG. Pires V, et al. J Appl Microbiol. 2023 Jun 1;134(6):lxad122. doi: 10.1093/jambio/lxad122. J Appl Microbiol. 2023. PMID: 37307226
AIMS: Isolation and characterization of lactobacilli from human milk and determination of their probiotic, technological, and in vitro health-promoting properties with a view to their potential use in food fermentation. METHODS AND RESULTS: Seven lactobacilli isolates were …
AIMS: Isolation and characterization of lactobacilli from human milk and determination of their probiotic, technological, and in vitro …
Apohemoglobin-haptoglobin complexes attenuate the hypertensive response to low-molecular-weight polymerized hemoglobin.
Belcher DA, Munoz C, Pires IS, Williams AT, Cabrales P, Palmer AF. Belcher DA, et al. Blood Adv. 2020 Jun 23;4(12):2739-2750. doi: 10.1182/bloodadvances.2020002045. Blood Adv. 2020. PMID: 32559292 Free PMC article.
This study evaluated the protective activity of administering the apoHb-Hp complex to mitigate the vasoactive response induced by the transfusion of LMW PolyHb. Hp binding to PolyHb was characterized in vitro. The effectiveness of apoHb-Hp administration on reducing the va …
This study evaluated the protective activity of administering the apoHb-Hp complex to mitigate the vasoactive response induced by the transf …
Effect of restorative treatment with endocrown and ferrule on the mechanical behavior of anterior endodontically treated teeth: An in vitro analysis.
Silva-Sousa AC, Moris ICM, Barbosa AFS, Silva-Sousa YTC, Sousa-Neto MD, Pires CRF, Gomes EA. Silva-Sousa AC, et al. J Mech Behav Biomed Mater. 2020 Dec;112:104019. doi: 10.1016/j.jmbbm.2020.104019. Epub 2020 Aug 13. J Mech Behav Biomed Mater. 2020. PMID: 32829166
Human canines were treated endodontically and distributed in five groups (n = 10): sound teeth (S), crown associated with glass fiber post (GFP) and ferrule (GFP(f+)) and that without ferrule (GFP(f-)), and endocrown with ferrule (E(f+)) and that without ferr …
Human canines were treated endodontically and distributed in five groups (n = 10): sound teeth (S), crown associated with glass fiber post ( …
Development and in vitro characterization of a bivalent DNA containing HN and F genes of velogenic Newcastle disease virus.
Chaturvedi U, Kalim S, Desai G, Ratta B, Kumar R, Ravindra PV, Kumar S, Dash BB, Tiwari S, Sahoo AP, Tiwari AK. Chaturvedi U, et al. Indian J Exp Biol. 2011 Feb;49(2):140-5. Indian J Exp Biol. 2011. PMID: 21428216
Envelope glycoproteins i.e. hemagglutinin-neuraminidase (HN) and the fusion (F), elicit protective immune response. In this study, HN and F genes of velogenic (virulent) strain were amplified and cloned at multiple cloning sites A and B, respectively into pIRES …
Envelope glycoproteins i.e. hemagglutinin-neuraminidase (HN) and the fusion (F), elicit protective immune response. In this study, HN …
Familial STAG2 germline mutation defines a new human cohesinopathy.
Soardi FC, Machado-Silva A, Linhares ND, Zheng G, Qu Q, Pena HB, Martins TMM, Vieira HGS, Pereira NB, Melo-Minardi RC, Gomes CC, Gomez RS, Gomes DA, Pires DEV, Ascher DB, Yu H, Pena SDJ. Soardi FC, et al. NPJ Genom Med. 2017 Mar 20;2:7. doi: 10.1038/s41525-017-0009-4. eCollection 2017. NPJ Genom Med. 2017. PMID: 29263825 Free PMC article.
Intriguingly, recombinant STAG2 p.Ser327Asn binds normally to SCC1, WAPL, and SGO1 in vitro, suggesting the existence of unknown in vivo mechanisms that regulate the interaction between STAG2 and SCC1....
Intriguingly, recombinant STAG2 p.Ser327Asn binds normally to SCC1, WAPL, and SGO1 in vitro, suggesting the existence of unknown in v …
Chronic exposure to lipopolysaccharides as an in vitro model to simulate the impaired odontogenic potential of dental pulp cells under pulpitis conditions.
Mendes Soares IP, Anselmi C, Pires MLBA, Ribeiro RAO, Leite ML, Soares DG, DE Souza Costa CA, Hebling J. Mendes Soares IP, et al. J Appl Oral Sci. 2023 Jul 24;31:e20230032. doi: 10.1590/1678-7757-2023-0032. eCollection 2023. J Appl Oral Sci. 2023. PMID: 37493701 Free PMC article.
BACKGROUND: Simulating a bacterial-induced pulpitis environment in vitro may contribute to exploring mechanisms and bioactive molecules to counteract these adverse effects. ...CONCLUSION: The exposure to 10 g/mL LPS for seven days creates an inflammatory environment that i …
BACKGROUND: Simulating a bacterial-induced pulpitis environment in vitro may contribute to exploring mechanisms and bioactive molecul …
23 results