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Paracrine release from nonviral engineered adipose-derived stem cells promotes endothelial cell survival and migration in vitro.
Deveza L, Choi J, Imanbayev G, Yang F. Deveza L, et al. Stem Cells Dev. 2013 Feb 1;22(3):483-91. doi: 10.1089/scd.2012.0201. Epub 2012 Oct 5. Stem Cells Dev. 2013. PMID: 22889246 Free PMC article.
Here, we developed vascular endothelial growth factor (VEGF)-overexpressing ADSCs utilizing poly(beta-amino esters) (PBAEs), a hydrolytically biodegradable polymer, and examined the effects of paracrine release from nonviral modified ADSCs on the angiogenic potential of human umb …
Here, we developed vascular endothelial growth factor (VEGF)-overexpressing ADSCs utilizing poly(beta-amino esters) (PBAEs), a hydrolyticall …
Programming stem cells for therapeutic angiogenesis using biodegradable polymeric nanoparticles.
Keeney M, Deveza L, Yang F. Keeney M, et al. J Vis Exp. 2013 Sep 27;(79):e50736. doi: 10.3791/50736. J Vis Exp. 2013. PMID: 24121540 Free PMC article.
We described the processes for polymer synthesis, nanoparticle formation, transfecting stem cells in vitro, as well as methods for validating the efficacy of VEGF-expressing stem cells for promoting angiogenesis in a murine hindlimb ischemia model....
We described the processes for polymer synthesis, nanoparticle formation, transfecting stem cells in vitro, as well as methods for va …
Polymer-DNA Nanoparticle-Induced CXCR4 Overexpression Improves Stem Cell Engraftment and Tissue Regeneration in a Mouse Hindlimb Ischemia Model.
Deveza L, Choi J, Lee J, Huang N, Cooke J, Yang F. Deveza L, et al. Theranostics. 2016 May 23;6(8):1176-89. doi: 10.7150/thno.12866. eCollection 2016. Theranostics. 2016. PMID: 27279910 Free PMC article.
Importantly, assessment of CXCR4-overexpressing stem cells in vitro revealed that CXCR4 overexpression induced changes in paracrine signaling of stem cells, promoting a therapeutically desirable pro-angiogenic and anti-inflammatory phenotype. ...
Importantly, assessment of CXCR4-overexpressing stem cells in vitro revealed that CXCR4 overexpression induced changes in paracrine s …