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Blood glutamate scavenging as a novel glutamate-based therapeutic approach for post-stroke depression.
Gruenbaum BF, Kutz R, Zlotnik A, Boyko M. Gruenbaum BF, et al. Ther Adv Psychopharmacol. 2020 Feb 17;10:2045125320903951. doi: 10.1177/2045125320903951. eCollection 2020. Ther Adv Psychopharmacol. 2020. PMID: 32110376 Free PMC article. Review.
Minimizing secondary brain damage and neuropsychiatric consequences associated with excess glutamate concentrations is a vital part of stroke management. The blood glutamate scavengers, oxaloacetate and pyruvate, degrade glutamate in the blood to its inactive metabolite, 2 …
Minimizing secondary brain damage and neuropsychiatric consequences associated with excess glutamate concentrations is a vital part o …
Diet's Impact on Post-Traumatic Brain Injury Depression: Exploring Neurodegeneration, Chronic Blood-Brain Barrier Destruction, and Glutamate Neurotoxicity Mechanisms.
Boyko M, Gruenbaum BF, Oleshko A, Merzlikin I, Zlotnik A. Boyko M, et al. Nutrients. 2023 Nov 4;15(21):4681. doi: 10.3390/nu15214681. Nutrients. 2023. PMID: 37960334 Free PMC article. Review.
A healthy blood-brain barrier (BBB) plays a crucial role in guarding the brain against elevated levels of blood glutamate, making its permeability a vital aspect of glutamate regulation within the brain. Studies have shown the efficacy of reducing excess glutamate in the b …
A healthy blood-brain barrier (BBB) plays a crucial role in guarding the brain against elevated levels of blood glutamate, making its permea …
A Complex Diving-For-Food Task to Investigate Social Organization and Interactions in Rats.
Gruenbaum BF, Frank D, Savir S, Shiyntum HN, Kuts R, Vinokur M, Melamed I, Dubilet M, Zlotnik A, Boyko M. Gruenbaum BF, et al. J Vis Exp. 2021 May 8;(171). doi: 10.3791/61763. J Vis Exp. 2021. PMID: 34028432
For many species, where status is a vital motivator that can affect health, social hierarchies influence behavior. ...
For many species, where status is a vital motivator that can affect health, social hierarchies influence behavior. ...
The Integrity of the Blood-Brain Barrier as a Critical Factor for Regulating Glutamate Levels in Traumatic Brain Injury.
Boyko M, Gruenbaum BF, Frank D, Natanel D, Negev S, Azab AN, Barsky G, Knyazer B, Kofman O, Zlotnik A. Boyko M, et al. Int J Mol Sci. 2023 Mar 20;24(6):5897. doi: 10.3390/ijms24065897. Int J Mol Sci. 2023. PMID: 36982969 Free PMC article.
We conclude that a healthy BBB protects the brain from high levels of blood glutamate, and the permeability of the BBB is a vital component in regulating levels of glutamate in the brain. These findings bring a new approach to treating the consequences of TBI and other dis …
We conclude that a healthy BBB protects the brain from high levels of blood glutamate, and the permeability of the BBB is a vital com …
Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl4) Exposure Through an Orogastric Tube.
Frank D, Savir S, Gruenbaum BF, Melamed I, Grinshpun J, Kuts R, Knyazer B, Zlotnik A, Vinokur M, Boyko M. Frank D, et al. J Vis Exp. 2020 Apr 28;(158):10.3791/60695. doi: 10.3791/60695. J Vis Exp. 2020. PMID: 32420997 Free PMC article.
Acute liver injury (ALI) plays a crucial role in the development of hepatic failure, which is characterized by severe liver dysfunction including complications such as hepatic encephalopathy and impaired protein synthesis. Appropriate animal models are vital to test the me …
Acute liver injury (ALI) plays a crucial role in the development of hepatic failure, which is characterized by severe liver dysfunction incl …
Head mounted DMD based projection system for natural and prosthetic visual stimulation in freely moving rats.
Arens-Arad T, Farah N, Ben-Yaish S, Zlotnik A, Zalevsky Z, Mandel Y. Arens-Arad T, et al. Sci Rep. 2016 Oct 12;6:34873. doi: 10.1038/srep34873. Sci Rep. 2016. PMID: 27731346 Free PMC article.
Visual cortex activity data was recorded simultaneously with pattern projection, further highlighting the importance of the system for prosthetic vision studies. This novel head mounted projection system may prove to be a vital tool in studying natural and artificial visio …
Visual cortex activity data was recorded simultaneously with pattern projection, further highlighting the importance of the system for prost …
Comparison of the effectiveness of high flow nasal oxygen cannula vs. standard non-rebreather oxygen face mask in post-extubation intensive care unit patients.
Brotfain E, Zlotnik A, Schwartz A, Frenkel A, Koyfman L, Gruenbaum SE, Klein M. Brotfain E, et al. Isr Med Assoc J. 2014 Nov;16(11):718-22. Isr Med Assoc J. 2014. PMID: 25558703 Free article.
The patients were allocated to two treatment groups: HFNC (34 patients, group 1) and non-rebreathing oxygen face mask (NRB) (33 patients, group 2). Vital respiratory and hemodynamic parameters were assessed prior to extubation and 6 hours after extubation. ...
The patients were allocated to two treatment groups: HFNC (34 patients, group 1) and non-rebreathing oxygen face mask (NRB) (33 patients, gr …