Mesoporous silica nanoparticles incorporated with Ir(III) complexes: From photophysics to photodynamic therapy

Bianca M Estevão; Raquel R C Vilela; Isabella P Geremias; Kassio P S Zanoni; Andrea S S de Camargo; Valtencir Zucolotto

doi:10.1016/j.pdpdt.2022.103052

Mesoporous silica nanoparticles incorporated with Ir(III) complexes: From photophysics to photodynamic therapy

Photodiagnosis Photodyn Ther. 2022 Dec:40:103052. doi: 10.1016/j.pdpdt.2022.103052. Epub 2022 Aug 5.

Authors

Bianca M Estevão¹, Raquel R C Vilela², Isabella P Geremias³, Kassio P S Zanoni⁴, Andrea S S de Camargo⁵, Valtencir Zucolotto³

Affiliations

¹ Nanomedicine and Nanotoxicology Group, São Carlos Institute of Physics, University of São Paulo, São Carlos, SP 13566-590, Brazil. Electronic address: estevaobm@usp.br.
² Laboratory of Spectroscopy of Functional Materials, São Carlos Institute of Physics, University of São Paulo, São Carlos, SP 13566-590, Brazil. Electronic address: raquelvilela@usp.br.
³ Nanomedicine and Nanotoxicology Group, São Carlos Institute of Physics, University of São Paulo, São Carlos, SP 13566-590, Brazil.
⁴ Laboratory of Spectroscopy of Functional Materials, São Carlos Institute of Physics, University of São Paulo, São Carlos, SP 13566-590, Brazil; Molecular Optoelectronic Devices, Instituto de Ciencia Molecular (ICMol), University of Valencia, Catedrático J. Beltrán 2, Paterna, Valencia 46980, Spain.
⁵ Laboratory of Spectroscopy of Functional Materials, São Carlos Institute of Physics, University of São Paulo, São Carlos, SP 13566-590, Brazil.

PMID: 35934182
DOI: 10.1016/j.pdpdt.2022.103052

Abstract

Organically modified mesoporous silica nanoparticles (MSNs) containing Ir complexes (Ir1, Ir2 and Ir3) were successfully synthesized. These Ir-entrapped MCM41-COOH nanoparticles have shown relevant photophysical characteristics including high efficiency in the photoproduction and delivery of singlet oxygen (¹O₂), which is particularly promising for photodynamic therapy (PDT) applications. In vitro tests have evidenced that complex@MCM41-COOH are able to reduce cell proliferation after 10 min of blue-light irradiation in Hep-G2 liver cancer cells.

Keywords: Ir(III) complexes; Liver cancer; Mesoporous silica nanoparticles; PDT; Photodynamic Therapy; Photophysics.

MeSH terms

Cell Line, Tumor
Nanoparticles*
Photochemotherapy* / methods
Photosensitizing Agents / pharmacology
Photosensitizing Agents / therapeutic use
Silicon Dioxide
Singlet Oxygen

Substances

Silicon Dioxide
Photosensitizing Agents
Singlet Oxygen