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1971 1
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1993 1
1994 1
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2001 1
2002 1
2004 1
2005 2
2007 2
2008 1
2009 1
2010 2
2012 3
2013 2
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2017 7
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2020 8
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76 results

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Page 1
Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects.
Edwards JJ, Rouillard AD, Fernandez NF, Wang Z, Lachmann A, Shankaran SS, Bisgrove BW, Demarest B, Turan N, Srivastava D, Bernstein D, Deanfield J, Giardini A, Porter G, Kim R, Roberts AE, Newburger JW, Goldmuntz E, Brueckner M, Lifton RP, Seidman CE, Chung WK, Tristani-Firouzi M, Yost HJ, Ma'ayan A, Gelb BD. Edwards JJ, et al. JACC Basic Transl Sci. 2020 Apr 8;5(4):376-386. doi: 10.1016/j.jacbts.2020.01.012. eCollection 2020 Apr. JACC Basic Transl Sci. 2020. PMID: 32368696 Free PMC article.
This approach enabled the authors to identify an association between left ventricular outflow tract obstruction lesions and genes associated with the WAVE2 complex and regulation of small GTPase-mediated signal transduction. ...
This approach enabled the authors to identify an association between left ventricular outflow tract obstruction lesions and genes ass …
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, … See abstract for full author list ➔ Klionsky DJ, et al. Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356. Autophagy. 2016. PMID: 26799652 Free PMC article. No abstract available.
Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults.
Langelier C, Kalantar KL, Moazed F, Wilson MR, Crawford ED, Deiss T, Belzer A, Bolourchi S, Caldera S, Fung M, Jauregui A, Malcolm K, Lyden A, Khan L, Vessel K, Quan J, Zinter M, Chiu CY, Chow ED, Wilson J, Miller S, Matthay MA, Pollard KS, Christenson S, Calfee CS, DeRisi JL. Langelier C, et al. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12353-E12362. doi: 10.1073/pnas.1809700115. Epub 2018 Nov 27. Proc Natl Acad Sci U S A. 2018. PMID: 30482864 Free PMC article.
Lower respiratory tract infections (LRTIs) lead to more deaths each year than any other infectious disease category. ...
Lower respiratory tract infections (LRTIs) lead to more deaths each year than any other infectious disease category. ...
Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system.
Workman MJ, Mahe MM, Trisno S, Poling HM, Watson CL, Sundaram N, Chang CF, Schiesser J, Aubert P, Stanley EG, Elefanty AG, Miyaoka Y, Mandegar MA, Conklin BR, Neunlist M, Brugmann SA, Helmrath MA, Wells JM. Workman MJ, et al. Nat Med. 2017 Jan;23(1):49-59. doi: 10.1038/nm.4233. Epub 2016 Nov 21. Nat Med. 2017. PMID: 27869805 Free PMC article.
The enteric nervous system (ENS) of the gastrointestinal tract controls many diverse functions, including motility and epithelial permeability. ...This is, to the best of our knowledge, the first demonstration of human-PSC-derived intestinal tissue with a functional ENS an …
The enteric nervous system (ENS) of the gastrointestinal tract controls many diverse functions, including motility and epithelial per …
Single-cell analysis of cardiogenesis reveals basis for organ-level developmental defects.
de Soysa TY, Ranade SS, Okawa S, Ravichandran S, Huang Y, Salunga HT, Schricker A, Del Sol A, Gifford CA, Srivastava D. de Soysa TY, et al. Nature. 2019 Aug;572(7767):120-124. doi: 10.1038/s41586-019-1414-x. Epub 2019 Jul 24. Nature. 2019. PMID: 31341279 Free PMC article.
A network-based computational method for single-cell RNA-sequencing analysis that predicts lineage-specifying transcription factors(2,3) identified Hand2 as a specifier of outflow tract cells but not right ventricular cells, despite the failure of right ventricular formati …
A network-based computational method for single-cell RNA-sequencing analysis that predicts lineage-specifying transcription factors(2,3) ide …
Kidney and urinary tract involvement in systemic mastocytosis.
Bharati J, Shah N, Desai A, Gladstone D, Krushna Das C, Nieto MJ, Jhaveri KD, Izzedine H. Bharati J, et al. Nephrol Dial Transplant. 2023 Oct 31;38(11):2456-2463. doi: 10.1093/ndt/gfad081. Nephrol Dial Transplant. 2023. PMID: 37113073 Review.
Whereas bone marrow, skin, lymph nodes, spleen and gastrointestinal tract are commonly involved, kidneys are rarely involved directly by SM. ...In this narrative review we discuss the various ways kidneys (and the urinary tract) are involved in patients with SM....
Whereas bone marrow, skin, lymph nodes, spleen and gastrointestinal tract are commonly involved, kidneys are rarely involved directly …
ATAC-Seq Reveals an Isl1 Enhancer That Regulates Sinoatrial Node Development and Function.
Galang G, Mandla R, Ruan H, Jung C, Sinha T, Stone NR, Wu RS, Mannion BJ, Allu PKR, Chang K, Rammohan A, Shi MB, Pennacchio LA, Black BL, Vedantham V. Galang G, et al. Circ Res. 2020 Dec 4;127(12):1502-1518. doi: 10.1161/CIRCRESAHA.120.317145. Epub 2020 Oct 12. Circ Res. 2020. PMID: 33044128 Free PMC article.
The mouse SAN enhancer also directed reporter activity to the inflow tract in developing zebrafish hearts, demonstrating deep conservation of its upstream regulatory network. ...
The mouse SAN enhancer also directed reporter activity to the inflow tract in developing zebrafish hearts, demonstrating deep conserv …
Dopamine subsystems that track internal states.
Grove JCR, Gray LA, La Santa Medina N, Sivakumar N, Ahn JS, Corpuz TV, Berke JD, Kreitzer AC, Knight ZA. Grove JCR, et al. Nature. 2022 Aug;608(7922):374-380. doi: 10.1038/s41586-022-04954-0. Epub 2022 Jul 13. Nature. 2022. PMID: 35831501 Free PMC article.
A major subset of dopaminergic neurons tracks changes in systemic hydration that occur tens of minutes after thirsty mice drink water, whereas different dopaminergic neurons respond to nutrients in the gastrointestinal tract. We show that information about fluid balance is …
A major subset of dopaminergic neurons tracks changes in systemic hydration that occur tens of minutes after thirsty mice drink water, where …
Improving prime editing with an endogenous small RNA-binding protein.
Yan J, Oyler-Castrillo P, Ravisankar P, Ward CC, Levesque S, Jing Y, Simpson D, Zhao A, Li H, Yan W, Goudy L, Schmidt R, Solley SC, Gilbert LA, Chan MM, Bauer DE, Marson A, Parsons LR, Adamson B. Yan J, et al. Nature. 2024 Apr;628(8008):639-647. doi: 10.1038/s41586-024-07259-6. Epub 2024 Apr 3. Nature. 2024. PMID: 38570691 Free PMC article.
Further investigation revealed that La promotes prime editing across approaches (PE2, PE3, PE4 and PE5), edit types (substitutions, insertions and deletions), endogenous loci and cell types but has no consistent effect on genome-editing approaches that rely on standard, unextende …
Further investigation revealed that La promotes prime editing across approaches (PE2, PE3, PE4 and PE5), edit types (substitutions, insertio …
ZBTB46 defines and regulates ILC3s that protect the intestine.
Zhou W, Zhou L, Zhou J; JRI Live Cell Bank; Chu C, Zhang C, Sockolow RE, Eberl G, Sonnenberg GF. Zhou W, et al. Nature. 2022 Sep;609(7925):159-165. doi: 10.1038/s41586-022-04934-4. Epub 2022 Jul 13. Nature. 2022. PMID: 35831503 Free PMC article.
RORgammat is a lineage-specifying transcription factor that is expressed by immune cells that are enriched in the gastrointestinal tract and promote immunity, inflammation and tissue homeostasis(1-15). ...
RORgammat is a lineage-specifying transcription factor that is expressed by immune cells that are enriched in the gastrointestinal tract …
76 results