PERK-Mediated Cholesterol Excretion from IDH Mutant Glioma Determines Anti-Tumoral Polarization of Microglia.
Wang T, Zhou Y, Fan Y, Duan H, Guo X, Chang J, Jiang Y, Li C, Fu Z, Gao Y, Guo X, Sidlauskas K, He Z, Da Costa C, Sheng X, Wu D, Yuan J, Li H, He Y, Mou Y, Li N.
Wang T, et al.
Adv Sci (Weinh). 2023 Jul;10(20):e2205949. doi: 10.1002/advs.202205949. Epub 2023 May 11.
Adv Sci (Weinh). 2023.
PMID: 37166058
Free PMC article.
Here, it is demonstrated that gliomas expressing mutant IDH determine M1-like polarization of GAMs, while archetypal IDH induces M2-like polarization. ...Further, a synthetic PERK activator, CCT020312 is introduced, which markedly stimulates cholesterol efflux from …
Here, it is demonstrated that gliomas expressing mutant IDH determine M1-like polarization of GAMs, while archetypal IDH induces M2-l …