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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
1983 2
1984 2
1985 1
1989 1
1991 3
1992 1
1994 3
1995 1
1996 1
1998 2
1999 1
2000 3
2001 6
2002 3
2003 3
2004 5
2005 1
2006 6
2007 4
2008 2
2009 3
2010 7
2011 6
2012 7
2013 6
2014 7
2015 5
2016 5
2017 9
2018 5
2019 6
2020 9
2021 12
2022 4
2023 9
2024 5
2025 1

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147 results

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Page 1
Efanesoctocog Alfa Prophylaxis for Patients with Severe Hemophilia A.
von Drygalski A, Chowdary P, Kulkarni R, Susen S, Konkle BA, Oldenburg J, Matino D, Klamroth R, Weyand AC, Jimenez-Yuste V, Nogami K, Poloskey S, Winding B, Willemze A, Knobe K; XTEND-1 Trial Group. von Drygalski A, et al. N Engl J Med. 2023 Jan 26;388(4):310-318. doi: 10.1056/NEJMoa2209226. N Engl J Med. 2023. PMID: 36720133 Clinical Trial.
In the overall population, nearly all bleeding episodes (97%) resolved with one injection of efanesoctocog alfa. Weekly prophylaxis with efanesoctocog alfa provided mean factor VIII activity of more than 40 IU per deciliter for the majority of the week and of 15 IU per dec …
In the overall population, nearly all bleeding episodes (97%) resolved with one injection of efanesoctocog alfa. Weekly prophylaxis w …
Phase 3 Trial of Concizumab in Hemophilia with Inhibitors.
Matsushita T, Shapiro A, Abraham A, Angchaisuksiri P, Castaman G, Cepo K, d'Oiron R, Frei-Jones M, Goh AS, Haaning J, Hald Jacobsen S, Mahlangu J, Mathias M, Nogami K, Skovgaard Rasmussen J, Stasyshyn O, Tran H, Vilchevska K, Villarreal Martinez L, Windyga J, You CW, Zozulya N, Zulfikar B, Jiménez-Yuste V; explorer7 Investigators. Matsushita T, et al. N Engl J Med. 2023 Aug 31;389(9):783-794. doi: 10.1056/NEJMoa2216455. N Engl J Med. 2023. PMID: 37646676 Clinical Trial.
After a treatment pause due to nonfatal thromboembolic events in three patients receiving concizumab, including one from the explorer7 trial, concizumab therapy was restarted with a loading dose of 1.0 mg per kilogram of body weight, followed by 0.2 mg per kilogram daily ( …
After a treatment pause due to nonfatal thromboembolic events in three patients receiving concizumab, including one from the explorer …
Molecular classification and diagnostics of upper urinary tract urothelial carcinoma.
Fujii Y, Sato Y, Suzuki H, Kakiuchi N, Yoshizato T, Lenis AT, Maekawa S, Yokoyama A, Takeuchi Y, Inoue Y, Ochi Y, Shiozawa Y, Aoki K, Yoshida K, Kataoka K, Nakagawa MM, Nannya Y, Makishima H, Miyakawa J, Kawai T, Morikawa T, Shiraishi Y, Chiba K, Tanaka H, Nagae G, Sanada M, Sugihara E, Sato TA, Nakagawa T, Fukayama M, Ushiku T, Aburatani H, Miyano S, Coleman JA, Homma Y, Solit DB, Kume H, Ogawa S. Fujii Y, et al. Cancer Cell. 2021 Jun 14;39(6):793-809.e8. doi: 10.1016/j.ccell.2021.05.008. Cancer Cell. 2021. PMID: 34129823 Free PMC article.
Upper urinary tract urothelial carcinoma (UTUC) is one of the common urothelial cancers. Its molecular pathogenesis, however, is poorly understood, with no useful biomarkers available for accurate diagnosis and molecular classification. ...
Upper urinary tract urothelial carcinoma (UTUC) is one of the common urothelial cancers. Its molecular pathogenesis, however, is poor …
Patterns of somatic structural variation in human cancer genomes.
Li Y, Roberts ND, Wala JA, Shapira O, Schumacher SE, Kumar K, Khurana E, Waszak S, Korbel JO, Haber JE, Imielinski M; PCAWG Structural Variation Working Group; Weischenfeldt J, Beroukhim R, Campbell PJ; PCAWG Consortium. Li Y, et al. Nature. 2020 Feb;578(7793):112-121. doi: 10.1038/s41586-019-1913-9. Epub 2020 Feb 5. Nature. 2020. PMID: 32025012 Free PMC article.
Replication-based mechanisms of rearrangement generate varied chromosomal structures with low-level copy-number gains and frequent inverted rearrangements. One prominent structure consists of 2-7 templates copied from distinct regions of the genome strung together within …
Replication-based mechanisms of rearrangement generate varied chromosomal structures with low-level copy-number gains and frequent inverted …
Landscape of genetic lesions in 944 patients with myelodysplastic syndromes.
Haferlach T, Nagata Y, Grossmann V, Okuno Y, Bacher U, Nagae G, Schnittger S, Sanada M, Kon A, Alpermann T, Yoshida K, Roller A, Nadarajah N, Shiraishi Y, Shiozawa Y, Chiba K, Tanaka H, Koeffler HP, Klein HU, Dugas M, Aburatani H, Kohlmann A, Miyano S, Haferlach C, Kern W, Ogawa S. Haferlach T, et al. Leukemia. 2014 Feb;28(2):241-7. doi: 10.1038/leu.2013.336. Epub 2013 Nov 13. Leukemia. 2014. PMID: 24220272 Free PMC article.
In total, 944 patients with various MDS subtypes were screened for known/putative mutations/deletions in 104 genes using targeted deep sequencing and array-based genomic hybridization. In total, 845/944 patients (89.5%) harbored at least one mutation (median, 3 per patient …
In total, 944 patients with various MDS subtypes were screened for known/putative mutations/deletions in 104 genes using targeted deep seque …
Function and 3D structure of the N-glycans on glycoproteins.
Nagae M, Yamaguchi Y. Nagae M, et al. Int J Mol Sci. 2012;13(7):8398-8429. doi: 10.3390/ijms13078398. Epub 2012 Jul 6. Int J Mol Sci. 2012. PMID: 22942711 Free PMC article. Review.
Glycosylation is one of the most common post-translational modifications in eukaryotic cells and plays important roles in many biological processes, such as the immune response and protein quality control systems. ...
Glycosylation is one of the most common post-translational modifications in eukaryotic cells and plays important roles in many biolog …
Intrinsic capacity in acutely hospitalized older adults.
Nagae M, Umegaki H, Komiya H, Nakashima H, Fujisawa C, Watanabe K, Yamada Y, Miyahara S. Nagae M, et al. Exp Gerontol. 2023 Aug;179:112247. doi: 10.1016/j.exger.2023.112247. Epub 2023 Jun 27. Exp Gerontol. 2023. PMID: 37380006 Free article.
Mean composite IC score was 6.5 1.8, and 95.6 % of participants had impairment in at least one IC domain. A higher composite IC score was independently associated with lower frequency of in-hospital death (odds ratio [OR] 0.59) and HACs (OR 0.71), higher frequency of disch …
Mean composite IC score was 6.5 1.8, and 95.6 % of participants had impairment in at least one IC domain. A higher composite IC score …
Curative and palliative MRI-guided laser ablation for drug-resistant epilepsy.
Brown MG, Drees C, Nagae LM, Thompson JA, Ojemann S, Abosch A. Brown MG, et al. J Neurol Neurosurg Psychiatry. 2018 Apr;89(4):425-433. doi: 10.1136/jnnp-2017-316003. Epub 2017 Oct 30. J Neurol Neurosurg Psychiatry. 2018. PMID: 29084870 Review.
It is characterised by seizures resulting from aberrant hypersynchronous neural activity. Approximately one-third of newly diagnosed epilepsy cases fail to become seizure-free in response to antiseizure drugs. ...
It is characterised by seizures resulting from aberrant hypersynchronous neural activity. Approximately one-third of newly diagnosed …
True significance of N-acetylglucosaminyltransferases GnT-III, V and α1,6 fucosyltransferase in epithelial-mesenchymal transition and cancer.
Taniguchi N, Ohkawa Y, Maeda K, Harada Y, Nagae M, Kizuka Y, Ihara H, Ikeda Y. Taniguchi N, et al. Mol Aspects Med. 2021 Jun;79:100905. doi: 10.1016/j.mam.2020.100905. Epub 2020 Sep 30. Mol Aspects Med. 2021. PMID: 33010941 Review.
Among the over 200 known glycosyltransferases and related genes, beta 1,6 N-acetylglucosaminyltransferase V (GnT-V) (the MGAT5 gene) and alpha 1,6 fucosyltransferase (FUT8) (the FUT8 gene) are representative enzymes in this respect because changes in glycans caused by these genes …
Among the over 200 known glycosyltransferases and related genes, beta 1,6 N-acetylglucosaminyltransferase V (GnT-V) (the MGAT5 gene) and alp …
Loss of viral genome with altered immune microenvironment during tumour progression of Epstein-Barr virus-associated gastric carcinoma.
Kondo A, Shinozaki-Ushiku A, Rokutan H, Kunita A, Ikemura M, Yamashita H, Seto Y, Nagae G, Tatsuno K, Aburatani H, Koinuma D, Ushiku T. Kondo A, et al. J Pathol. 2023 Jun;260(2):124-136. doi: 10.1002/path.6067. Epub 2023 Mar 20. J Pathol. 2023. PMID: 36806225
Epstein-Barr virus (EBV) is one of the major drivers of gastric carcinogenesis. EBV infection is established before tumour initiation and is generally maintained throughout tumour development; however, the significance of EBV in tumour maintenance and progression remains t …
Epstein-Barr virus (EBV) is one of the major drivers of gastric carcinogenesis. EBV infection is established before tumour initiation …
147 results