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1988 1
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Page 1
PROMISE Registry: A prostate cancer registry of outcomes and germline mutations for improved survival and treatment effectiveness.
Paller CJ, Barata PC, Lorentz J, Appleman LJ, Armstrong AJ, DeMarco TA, Dreicer R, Elrod JAB, Fleming M, George C, Heath EI, Hussain MHA, Mao S, McKay RR, Morgans AK, Orton M, Pili R, Riedel E, Saraiya B, Sigmond J, Sokolova A, Stadler WM, Tran C, Macario N, Vinson J, Green R, Cheng HH; PROMISE Trial Investigators. Paller CJ, et al. Prostate. 2024 Feb;84(3):292-302. doi: 10.1002/pros.24650. Epub 2023 Nov 14. Prostate. 2024. PMID: 37964482
Patients will be followed for 15 years and clinical data with real time patient reported outcomes will be collected. Eligible patients will enter long-term follow-up (6-month PRO surveys and medical record retrieval). ...
Patients will be followed for 15 years and clinical data with real time patient reported outcomes will be collected. Eligible patient …
Quantitative real time PCR of deoxycytidine kinase mRNA by Light Cycler PCR in relation to enzyme activity and gemcitabine sensitivity.
Sigmond J, Kroep JR, Loves W, Codacci-Pisanelli G, Peters GJ. Sigmond J, et al. Cancer Lett. 2004 Sep 30;213(2):173-9. doi: 10.1016/j.canlet.2004.04.016. Cancer Lett. 2004. PMID: 15327832
Conventional Competitive Template-Reverse Transcriptase-Polymerase Chain Reaction (CT-RT-PCR) was correlated with real time PCR using a Light Cycler (LC) with SYBR-Green detection to enable rapid and sensitive detection of dCK mRNA expression. ...
Conventional Competitive Template-Reverse Transcriptase-Polymerase Chain Reaction (CT-RT-PCR) was correlated with real time PCR using …
Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer.
Sigmond J, Honeywell RJ, Postma TJ, Dirven CM, de Lange SM, van der Born K, Laan AC, Baayen JC, Van Groeningen CJ, Bergman AM, Giaccone G, Peters GJ. Sigmond J, et al. Ann Oncol. 2009 Jan;20(1):182-7. doi: 10.1093/annonc/mdn543. Epub 2008 Aug 12. Ann Oncol. 2009. PMID: 18701427 Free article. Clinical Trial.
These enzyme levels were sufficient to enable gemcitabine phosphorylation, leading to 130-3083 pmol gemcitabine nucleotides/g tissue. These data demonstrate for the first time that gemcitabine passes the blood-tumor barrier in GBM patients. ...
These enzyme levels were sufficient to enable gemcitabine phosphorylation, leading to 130-3083 pmol gemcitabine nucleotides/g tissue. These …
Combinations of 5-fluorouracil with UCN-01 or staurosporine.
Sigmond J, Comijn EM, Kamphuis JA, Peters GJ. Sigmond J, et al. Nucleosides Nucleotides Nucleic Acids. 2004 Oct;23(8-9):1503-6. doi: 10.1081/NCN-200027718. Nucleosides Nucleotides Nucleic Acids. 2004. PMID: 15571286
Quantitative real time PCR of deoxycytidine kinase mRNA by Light Cycler PCR; in relation to enzyme activity.
Sigmond J, Loves WJ, Kroep JR, Peters GJ. Sigmond J, et al. Nucleosides Nucleotides Nucleic Acids. 2004 Oct;23(8-9):1347-50. doi: 10.1081/NCN-200027611. Nucleosides Nucleotides Nucleic Acids. 2004. PMID: 15571256
Deoxycytidine kinase (dCK) is essential for the phosphorylation of several deoxyribonucleosides and various analogues such as gemcitabine (2',2'-difluorodeoxycytidine). We developed and optimized a sensitive real time Light Cycler (LC) PCR assay for dCK with SYBR green det …
Deoxycytidine kinase (dCK) is essential for the phosphorylation of several deoxyribonucleosides and various analogues such as gemcitabine (2 …
The long-term impact of routine intraoperative nerve monitoring during thyroid and parathyroid surgery.
Snyder SK, Sigmond BR, Lairmore TC, Govednik-Horny CM, Janicek AK, Jupiter DC. Snyder SK, et al. Surgery. 2013 Oct;154(4):704-11; discussion 711-3. doi: 10.1016/j.surg.2013.06.039. Epub 2013 Sep 3. Surgery. 2013. PMID: 24008089
The aim of this study was to evaluate the impact of IONM feedback on surgical outcomes over time at a single institution. METHODS: We conducted retrospective analysis of prospectively gathered data for 1,936 patients including 3,435 nerves at risk between March 2004 and Se …
The aim of this study was to evaluate the impact of IONM feedback on surgical outcomes over time at a single institution. METHODS: We …
Pharmacokinetic parameter sets of alfentanil revisited: optimal parameters for use in target controlled infusion and anaesthesia display systems.
Sigmond N, Baechtold M, Schumacher PM, Hartwich V, Schnider TW, Luginbühl M. Sigmond N, et al. Br J Anaesth. 2013 Aug;111(2):197-208. doi: 10.1093/bja/aet049. Epub 2013 Mar 19. Br J Anaesth. 2013. PMID: 23512864 Free article.
METHODS: With the dosing history from two studies in orthopaedic patients anaesthetized with propofol or inhalation anaesthetics the alfentanil plasma concentration over time was calculated with eight PK parameter sets. Median absolute performance error (MDAPE), log accura …
METHODS: With the dosing history from two studies in orthopaedic patients anaesthetized with propofol or inhalation anaesthetics the alfenta …
13 results