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Table representation of search results timeline featuring number of search results per year.

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1995 1
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64 results

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Page 1
Optimization of real-time analysis of sleep-wake cycle in mice.
Thankachan S, Gerashchenko A, Kastanenka KV, Bacskai BJ, Gerashchenko D. Thankachan S, et al. MethodsX. 2022 Aug 8;9:101811. doi: 10.1016/j.mex.2022.101811. eCollection 2022. MethodsX. 2022. PMID: 36065218 Free PMC article.
The process consists of EEG/EMG data acquisition, automated threshold calculation for real-time determination of sleep stages, sleep staging and EEG power spectrum analysis. ...A process of EEG/EMG recording and streamline analysis of sleep-wake cycle in real time i …
The process consists of EEG/EMG data acquisition, automated threshold calculation for real-time determination of sleep stages, sleep …
Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid beta aggregates in vivo in a mouse model of Alzheimer's disease.
Calvo-Rodriguez M, Kharitonova EK, Snyder AC, Hou SS, Sanchez-Mico MV, Das S, Fan Z, Shirani H, Nilsson KPR, Serrano-Pozo A, Bacskai BJ. Calvo-Rodriguez M, et al. Mol Neurodegener. 2024 Jan 18;19(1):6. doi: 10.1186/s13024-024-00702-2. Mol Neurodegener. 2024. PMID: 38238819 Free PMC article.
Although Abeta causes neuronal mitochondria reactive oxidative stress in vitro, this has never been directly observed in vivo in the living mouse brain. Here, we tested for the first time whether Abeta plaques and soluble Abeta oligomers induce mitochondrial oxidative stre …
Although Abeta causes neuronal mitochondria reactive oxidative stress in vitro, this has never been directly observed in vivo in the living …
Lifetime-based tomographic multiplexing.
Raymond SB, Boas DA, Bacskai BJ, Kumar AT. Raymond SB, et al. J Biomed Opt. 2010 Jul-Aug;15(4):046011. doi: 10.1117/1.3469797. J Biomed Opt. 2010. PMID: 20799813 Free PMC article.
We describe in vivo tomography of three spectrally overlapping fluorophores using fluorescence lifetime-based separation. Time-domain images are acquired using a voltage-gated, intensified charge-coupled device (CCD) in free-space transmission geometry with 750 nm Ti:sapph …
We describe in vivo tomography of three spectrally overlapping fluorophores using fluorescence lifetime-based separation. Time-domain …
Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer's disease model.
Zhao Q, Maci M, Miller MR, Zhou H, Zhang F, Algamal M, Lee YF, Hou SS, Perle SJ, Le H, Russ AN, Lo EH, Gerashchenko D, Gomperts SN, Bacskai BJ, Kastanenka KV. Zhao Q, et al. Mol Neurodegener. 2023 Dec 1;18(1):93. doi: 10.1186/s13024-023-00682-9. Mol Neurodegener. 2023. PMID: 38041158 Free PMC article.
RESULTS: APP-GAD-Cre mice exhibited impairments in sleep architecture including decreased time spent in NREM sleep, decreased delta power, and increased sleep fragmentation compared to nontransgenic (NTG) NTG-GAD-Cre mice. ...
RESULTS: APP-GAD-Cre mice exhibited impairments in sleep architecture including decreased time spent in NREM sleep, decreased delta p …
Slow Wave Sleep Is a Promising Intervention Target for Alzheimer's Disease.
Lee YF, Gerashchenko D, Timofeev I, Bacskai BJ, Kastanenka KV. Lee YF, et al. Front Neurosci. 2020 Jun 30;14:705. doi: 10.3389/fnins.2020.00705. eCollection 2020. Front Neurosci. 2020. PMID: 32714142 Free PMC article. Review.
Plaques and tangles are associated with sleep-wake cycle disruptions, including the disruptions in non-rapid eye movement (NREM) slow wave sleep (SWS). Alzheimer's patients spend less time in NREM sleep and exhibit decreased slow wave activity (SWA). ...
Plaques and tangles are associated with sleep-wake cycle disruptions, including the disruptions in non-rapid eye movement (NREM) slow wave s …
Alzheimer's disease: what multiphoton microscopy teaches us.
Bacskai BJ, Hyman BT. Bacskai BJ, et al. Neuroscientist. 2002 Oct;8(5):386-90. doi: 10.1177/107385802236963. Neuroscientist. 2002. PMID: 12374422 Review.
Multiphoton microscopy uses near infrared light that is benign to living tissue and penetrates more deeply than visible or UV light, permitting high-resolution imaging of these microscopic structures deep within the cortex of living transgenic mice over time. This in vivo …
Multiphoton microscopy uses near infrared light that is benign to living tissue and penetrates more deeply than visible or UV light, permitt …
Different microvascular alterations underlie microbleeds and microinfarcts.
van Veluw SJ, Scherlek AA, Freeze WM, Ter Telgte A, van der Kouwe AJ, Bacskai BJ, Frosch MP, Greenberg SM. van Veluw SJ, et al. Ann Neurol. 2019 Aug;86(2):279-292. doi: 10.1002/ana.25512. Epub 2019 Jun 14. Ann Neurol. 2019. PMID: 31152566 Free PMC article.
OBJECTIVE: Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of amyloid beta (Abeta) in the walls of cortical vessels and the accrual of microbleeds and microinfarcts over time. The relationship between CAA severity and microbleeds and microinfarcts as …
OBJECTIVE: Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of amyloid beta (Abeta) in the walls of cortical vessels a …
A time domain fluorescence tomography system for small animal imaging.
Kumar AT, Raymond SB, Dunn AK, Bacskai BJ, Boas DA. Kumar AT, et al. IEEE Trans Med Imaging. 2008 Aug;27(8):1152-63. doi: 10.1109/TMI.2008.918341. IEEE Trans Med Imaging. 2008. PMID: 18672432 Free PMC article.
We describe the application of a time domain diffuse fluorescence tomography system for whole body small animal imaging. ...These results suggest the practical feasibility and advantages of a time domain approach for whole body small animal fluorescence molecular im …
We describe the application of a time domain diffuse fluorescence tomography system for whole body small animal imaging. ...These res …
Accelerated amyloid angiopathy and related vascular alterations in a mixed murine model of Alzheimer´s disease and type two diabetes.
Vargas-Soria M, Ramos-Rodriguez JJ, Del Marco A, Hierro-Bujalance C, Carranza-Naval MJ, Calvo-Rodriguez M, van Veluw SJ, Stitt AW, Simó R, Bacskai BJ, Infante-Garcia C, Garcia-Alloza M. Vargas-Soria M, et al. Fluids Barriers CNS. 2022 Nov 7;19(1):88. doi: 10.1186/s12987-022-00380-6. Fluids Barriers CNS. 2022. PMID: 36345028 Free PMC article.
METHODS: To further explore these alterations when AD and T2D coexist, we have used in vivo multiphoton microscopy to analyze over time the Abeta deposition in the form of plaques and CAA in a relevant model of AD (APPswe/PS1dE9) combined with T2D (db/db). ...
METHODS: To further explore these alterations when AD and T2D coexist, we have used in vivo multiphoton microscopy to analyze over time …
Selective plane illumination microscopy (SPIM) with time-domain fluorescence lifetime imaging microscopy (FLIM) for volumetric measurement of cleared mouse brain samples.
Funane T, Hou SS, Zoltowska KM, van Veluw SJ, Berezovska O, Kumar ATN, Bacskai BJ. Funane T, et al. Rev Sci Instrum. 2018 May;89(5):053705. doi: 10.1063/1.5018846. Rev Sci Instrum. 2018. PMID: 29864842 Free PMC article.
We have developed an imaging technique which combines selective plane illumination microscopy with time-domain fluorescence lifetime imaging microscopy (SPIM-FLIM) for three-dimensional volumetric imaging of cleared mouse brains with micro- to mesoscopic resolution. ...
We have developed an imaging technique which combines selective plane illumination microscopy with time-domain fluorescence lifetime …
64 results