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Phosphodiesterase (PDE) 4 inhibition boosts Schwann cell myelination in a 3D regeneration model.
Schepers M, Malheiro A, Gamardo AS, Hellings N, Prickaerts J, Moroni L, Vanmierlo T, Wieringa P. Schepers M, et al. Eur J Pharm Sci. 2023 Jun 1;185:106441. doi: 10.1016/j.ejps.2023.106441. Epub 2023 Mar 31. Eur J Pharm Sci. 2023. PMID: 37004962 Free article.
To further investigate the differentiation promoting effects of roflumilast, we developed a 3D model of rat Schwann cell myelination that closely resembles the in vivo situation. ...Additionally, we created a unique regenerative model comprised of a 3D co-culture of rat …
To further investigate the differentiation promoting effects of roflumilast, we developed a 3D model of rat Schwann cell myelination …
Adrenergic Modulation of Hematopoiesis.
Maestroni GJM. Maestroni GJM. J Neuroimmune Pharmacol. 2020 Mar;15(1):82-92. doi: 10.1007/s11481-019-09840-7. Epub 2019 Feb 14. J Neuroimmune Pharmacol. 2020. PMID: 30762159 Review.
Other cell types that regulate HSC niches include sympathetic nerves, non-myelinating Schwann cells and a variety of mature hematopoietic cells such as macrophages, neutrophils, and megakaryocytes. ...
Other cell types that regulate HSC niches include sympathetic nerves, non-myelinating Schwann cells and a variety of mature hematopoi …
Changes in the Coding and Non-coding Transcriptome and DNA Methylome that Define the Schwann Cell Repair Phenotype after Nerve Injury.
Arthur-Farraj PJ, Morgan CC, Adamowicz M, Gomez-Sanchez JA, Fazal SV, Beucher A, Razzaghi B, Mirsky R, Jessen KR, Aitman TJ. Arthur-Farraj PJ, et al. Cell Rep. 2017 Sep 12;20(11):2719-2734. doi: 10.1016/j.celrep.2017.08.064. Cell Rep. 2017. PMID: 28903050 Free PMC article.
Repair Schwann cells play a critical role in orchestrating nerve repair after injury, but the cellular and molecular processes that generate them are poorly understood. ...We show that genes involved in the epithelial-mesenchymal transition are enriched in repair cells, an …
Repair Schwann cells play a critical role in orchestrating nerve repair after injury, but the cellular and molecular processes that g …
Characterization and Schwann Cell Seeding of up to 15.0 cm Long Spider Silk Nerve Conduits for Reconstruction of Peripheral Nerve Defects.
Kornfeld T, Vogt PM, Bucan V, Peck CT, Reimers K, Radtke C. Kornfeld T, et al. J Funct Biomater. 2016 Nov 30;7(4):30. doi: 10.3390/jfb7040030. J Funct Biomater. 2016. PMID: 27916868 Free PMC article.
Schwann cells (SCs) were isolated, cultured and purified. Cell purity was determined by immunofluorescence. ...After 7 and 21 days of culture, immunofluorescence for viability and determination of Schwann cell proliferation and migration throughout the conduits was …
Schwann cells (SCs) were isolated, cultured and purified. Cell purity was determined by immunofluorescence. ...After 7 and 21 days of …
Long-term Follow-up and Histological Correlation of Peripheral Nervous System Alterations in Neurofibromatosis Type 2.
Godel T, Bäumer P, Farschtschi S, Püschel K, Hofstadler B, Heiland S, Gelderblom M, Bendszus M, Hagel C, Mautner VF. Godel T, et al. Clin Neuroradiol. 2022 Mar;32(1):277-285. doi: 10.1007/s00062-021-01102-5. Epub 2021 Oct 15. Clin Neuroradiol. 2022. PMID: 34652463 Free PMC article.
Thus, symptoms of PNP may not primarily attributed to the initial schwannoma growth but to secondary long-term processes, with symptoms only occurring if a certain threshold is exceeded. Histology identified grouped areas of Schwann cell proliferations as the correlate of …
Thus, symptoms of PNP may not primarily attributed to the initial schwannoma growth but to secondary long-term processes, with symptoms only …