Gestational Vitamin D Supplementation Leads to Reduced Perinatal RXRA DNA Methylation: Results From the MAVIDOS Trial.
Curtis EM, Krstic N, Cook E, D'Angelo S, Crozier SR, Moon RJ, Murray R, Garratt E, Costello P, Cleal J, Ashley B, Bishop NJ, Kennedy S, Papageorghiou AT, Schoenmakers I, Fraser R, Gandhi SV, Prentice A, Javaid MK, Inskip HM, Godfrey KM, Bell CG, Lillycrop KA, Cooper C, Harvey NC; MAVIDOS Trial Group.
Curtis EM, et al.
J Bone Miner Res. 2019 Feb;34(2):231-240. doi: 10.1002/jbmr.3603. Epub 2019 Jan 18.
J Bone Miner Res. 2019.
PMID: 30321476
Free PMC article.
Clinical Trial.
We have previously demonstrated inverse associations between maternal 25(OH)-vitamin D status and perinatal DNA methylation at the retinoid-X-receptor-alpha (RXRA) locus and between RXRA methylation and offspring bone mass. In this study, we used an existing randomized trial …
We have previously demonstrated inverse associations between maternal 25(OH)-vitamin D status and perinatal DNA methylation at the retinoid- …