Unraveling a hidden player in lymphovascular invasion in bladder cancer

Benjamin Wolf; Rakesh K Jain

doi:10.1016/j.ccell.2024.02.007

Unraveling a hidden player in lymphovascular invasion in bladder cancer

Cancer Cell. 2024 Apr 8;42(4):509-512. doi: 10.1016/j.ccell.2024.02.007. Epub 2024 Mar 7.

Authors

Benjamin Wolf¹, Rakesh K Jain²

Affiliations

¹ Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Cox-7, Boston, MA 02114, USA.
² Edwin L. Steele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Cox-7, Boston, MA 02114, USA. Electronic address: rjain@mgh.harvard.edu.

PMID: 38458186
DOI: 10.1016/j.ccell.2024.02.007

Abstract

Tumor invasion into the lymphatic vasculature represents a critical step during malignant progression of epithelial cancers. In this issue of Cancer Cell, Zheng et al. unravel how cancer-associated fibroblasts interact with lymphatic endothelial cells and the extracellular matrix to promote lymphatic tumor invasion and suggest that these processes could be treatment targets.

MeSH terms

Endothelial Cells
Humans
Lymphatic Metastasis / pathology
Lymphatic Vessels* / pathology
Neoplasm Invasiveness / pathology
Urinary Bladder Neoplasms* / pathology