Aldh inhibitor restores auditory function in a mouse model of human deafness.
Zhu GJ, Gong S, Ma DB, Tao T, He WQ, Zhang L, Wang F, Qian XY, Zhou H, Fan C, Wang P, Chen X, Zhao W, Sun J, Chen H, Wang Y, Gao X, Zuo J, Zhu MS, Gao X, Wan G.
Zhu GJ, et al. Among authors: tao t.
PLoS Genet. 2020 Sep 24;16(9):e1009040. doi: 10.1371/journal.pgen.1009040. eCollection 2020 Sep.
PLoS Genet. 2020.
PMID: 32970669
Free PMC article.
Importantly, inhibition of retinoic acid signaling by the aldehyde dehydrogenase (Aldh) and retinoic acid receptor inhibitors promoted Pou4f3 expression in the cochlear tissue and suppressed the progression of hearing loss in the mutant mice. These data demonstrate Pou4f3 …
Importantly, inhibition of retinoic acid signaling by the aldehyde dehydrogenase (Aldh) and retinoic acid receptor inhibitors promote …