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Page 1
The making of a sweet modification: structure and function of O-GlcNAc transferase.
Janetzko J, Walker S. Janetzko J, et al. J Biol Chem. 2014 Dec 12;289(50):34424-32. doi: 10.1074/jbc.R114.604405. Epub 2014 Oct 21. J Biol Chem. 2014. PMID: 25336649 Free PMC article. Review.
An unexpected second function for O-GlcNAc transferase as a protease involved in cleaving the epigenetic regulator HCF-1 has also been reported. Recent structural and biochemical studies that provide insight into the mechanism of glycosylation and HCF-1 cleavage will be de …
An unexpected second function for O-GlcNAc transferase as a protease involved in cleaving the epigenetic regulator HCF-1 has also bee …
Protease-anti-protease compartmentalization in SARS-CoV-2 ARDS: Therapeutic implications.
McElvaney OF, Asakura T, Meinig SL, Torres-Castillo JL, Hagan RS, Gabillard-Lefort C, Murphy MP, Thorne LB, Borczuk A, Reeves EP, Zumwalt RE, Mikami Y, Carroll TP, Okuda K, Hogan G, McElvaney OJ, Clarke J, McEvoy NL, Mallon PW, McCarthy C, Curley G, Wolfgang MC, Boucher RC, McElvaney NG. McElvaney OF, et al. EBioMedicine. 2022 Mar;77:103894. doi: 10.1016/j.ebiom.2022.103894. Epub 2022 Feb 22. EBioMedicine. 2022. PMID: 35217407 Free PMC article.
The airway anti-protease, secretory leukoprotease inhibitor was decreased in SARS-CoV-2-infected lungs and cleaved in TA. In nsARDS, plasma AAT levels were elevated but TA samples had less AAT cleavage, with no detectable active NE in most samples. ...
The airway anti-protease, secretory leukoprotease inhibitor was decreased in SARS-CoV-2-infected lungs and cleaved in TA. In nsARDS, …
Mammalian cell proliferation requires noncatalytic functions of O-GlcNAc transferase.
Levine ZG, Potter SC, Joiner CM, Fei GQ, Nabet B, Sonnett M, Zachara NE, Gray NS, Paulo JA, Walker S. Levine ZG, et al. Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):e2016778118. doi: 10.1073/pnas.2016778118. Proc Natl Acad Sci U S A. 2021. PMID: 33419956 Free PMC article.
In one, it glycosylates thousands of different proteins, and in the other, it proteolytically cleaves another essential protein involved in gene expression. Deconvoluting OGT's myriad cellular roles has been challenging because genetic deletion is lethal; complementation m …
In one, it glycosylates thousands of different proteins, and in the other, it proteolytically cleaves another essential protein invol …
Structure and reconstitution of a hydrolase complex that may release peptidoglycan from the membrane after polymerization.
Schaefer K, Owens TW, Page JE, Santiago M, Kahne D, Walker S. Schaefer K, et al. Nat Microbiol. 2021 Jan;6(1):34-43. doi: 10.1038/s41564-020-00808-5. Epub 2020 Nov 9. Nat Microbiol. 2021. PMID: 33168989 Free PMC article.
Here, we show that a Staphylococcus aureus cell wall hydrolase and a membrane protein that contains eight transmembrane helices form a complex that may function as a peptidoglycan release factor. The complex cleaves nascent peptidoglycan internally to produce free oligomer …
Here, we show that a Staphylococcus aureus cell wall hydrolase and a membrane protein that contains eight transmembrane helices form a compl …
A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes.
Thomas C, Wetherall B, Levasseur MD, Harris RJ, Kerridge ST, Higgins JMG, Davies OR, Madgwick S. Thomas C, et al. Nat Commun. 2021 Jul 14;12(1):4322. doi: 10.1038/s41467-021-24554-2. Nat Commun. 2021. PMID: 34262048 Free PMC article.
Successful cell division relies on the timely removal of key cell cycle proteins such as securin. Securin inhibits separase, which cleaves the cohesin rings holding chromosomes together. Securin must be depleted before anaphase to ensure chromosome segregation occurs with …
Successful cell division relies on the timely removal of key cell cycle proteins such as securin. Securin inhibits separase, which cleave …
Biochemical reconstitution defines new functions for membrane-bound glycosidases in assembly of the bacterial cell wall.
Taguchi A, Page JE, Tsui HT, Winkler ME, Walker S. Taguchi A, et al. Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2103740118. doi: 10.1073/pnas.2103740118. Proc Natl Acad Sci U S A. 2021. PMID: 34475211 Free PMC article.
We propose that MltG's ability to complement the loss of MpgA in S. pneumoniae despite performing different cleavage chemistry is because it can cleave nascent peptidoglycan at the same distance from the lipid anchor....
We propose that MltG's ability to complement the loss of MpgA in S. pneumoniae despite performing different cleavage chemistry is because it …
Targeting the GD3 acetylation pathway selectively induces apoptosis in glioblastoma.
Birks SM, Danquah JO, King L, Vlasak R, Gorecki DC, Pilkington GJ. Birks SM, et al. Neuro Oncol. 2011 Sep;13(9):950-60. doi: 10.1093/neuonc/nor108. Epub 2011 Jul 31. Neuro Oncol. 2011. PMID: 21807667 Free PMC article.
Thus, we have demonstrated for the first time in primary glioblastoma that cleaving the acetyl group restores GD3, resulting in a reduction in tumor cell viability while normal astrocytes remain unaffected. Additionally, we have shown that glioblastoma viability is reduced …
Thus, we have demonstrated for the first time in primary glioblastoma that cleaving the acetyl group restores GD3, resulting in a red …
Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme.
Mukherjee M, Byrd T, Brawley VS, Bielamowicz K, Li XN, Merchant F, Maitra S, Sumazin P, Fuller G, Kew Y, Sun D, Powell SZ, Ahmed N, Zhang N, Pati D. Mukherjee M, et al. J Neurooncol. 2014 Aug;119(1):27-35. doi: 10.1007/s11060-014-1458-6. Epub 2014 May 4. J Neurooncol. 2014. PMID: 24792645 Free PMC article.
Separase, an enzyme that cleaves the chromosomal cohesin during mitosis, is overexpressed in a wide range of human epithelial cancers of breast, bone and prostate (Meyer et al., Clin Cancer Res 15(8):2703-2710, 2009). ...
Separase, an enzyme that cleaves the chromosomal cohesin during mitosis, is overexpressed in a wide range of human epithelial cancers …