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Retrospective Review of Chromane Analogues as Anti-protozoal Leads: A Decade's Worth of Evolution.
Jadhav SR, Karan Kumar B, Joshi RP, Suryakant CK, Chandu A, Muzaffar-Ur-Rehman M, Khetmalis YM, Nandikolla A, Murugesan S, Chandra Sekhar KVG. Jadhav SR, et al. Curr Top Med Chem. 2023;23(9):713-735. doi: 10.2174/1568026623666230214093147. Curr Top Med Chem. 2023. PMID: 36786146 Review.
This review aims to attempt to find better alternatives by scrutinizing natural and synthetic derivatives for which chromones and their analogues were discovered to be a new and highly effective scaffold for the treatment of neglected diseases, including compounds with dua …
This review aims to attempt to find better alternatives by scrutinizing natural and synthetic derivatives for which chromones and the …
Testing for association with rare variants in the coding and non-coding genome: RAVA-FIRST, a new approach based on CADD deleteriousness score.
Bocher O, Ludwig TE, Oglobinsky MS, Marenne G, Deleuze JF, Suryakant S, Odeberg J, Morange PE, Trégouët DA, Perdry H, Génin E. Bocher O, et al. PLoS Genet. 2022 Sep 16;18(9):e1009923. doi: 10.1371/journal.pgen.1009923. eCollection 2022 Sep. PLoS Genet. 2022. PMID: 36112662 Free PMC article.
RVAT require to aggregate rare variants in testing units and to filter variants to retain only the most likely causal ones. In the exome, genes are natural testing units and variants are usually filtered based on their functional consequences. However, when dealing with wh …
RVAT require to aggregate rare variants in testing units and to filter variants to retain only the most likely causal ones. In the exome, ge …