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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2000 1
2001 1
2003 4
2004 2
2007 2
2008 4
2009 4
2010 3
2011 5
2012 3
2013 3
2014 6
2015 7
2016 3
2017 7
2018 12
2019 10
2020 10
2021 25
2022 29
2023 18
2024 8

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151 results

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Page 1
Plasma proteins and onset of type 2 diabetes and diabetic complications: Proteome-wide Mendelian randomization and colocalization analyses.
Yuan S, Xu F, Li X, Chen J, Zheng J, Mantzoros CS, Larsson SC. Yuan S, et al. Cell Rep Med. 2023 Sep 19;4(9):101174. doi: 10.1016/j.xcrm.2023.101174. Epub 2023 Aug 30. Cell Rep Med. 2023. PMID: 37652020 Free PMC article.
Among 1,886 proteins, genetically predicted levels of 47 plasma proteins are associated with type 2 diabetes. Eleven of these proteins have strong support of colocalization. Seventeen proteins are associated with at least one diabetic complication, although a few have colo …
Among 1,886 proteins, genetically predicted levels of 47 plasma proteins are associated with type 2 diabetes. Eleven of these proteins have …
Telomere Length and Development of Systemic Lupus Erythematosus: A Mendelian Randomization Study.
Wang XF, Xu WJ, Wang FF, Leng R, Yang XK, Ling HZ, Fan YG, Tao JH, Shuai ZW, Zhang L, Ye DQ, Leng RX. Wang XF, et al. Arthritis Rheumatol. 2022 Dec;74(12):1984-1990. doi: 10.1002/art.42304. Epub 2022 Nov 4. Arthritis Rheumatol. 2022. PMID: 35830513

RESULTS: The results of the inverse variance-weighted method (odds ratio [OR] 2.96 [95% confidence interval (95% CI) 1.58-5.55], P < 0.001) showed strong evidence for a causal relationship between longer telomere length and risk of SLE in people with European ancestry.

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RESULTS: The results of the inverse variance-weighted method (odds ratio [OR] 2.96 [95% confidence interval (95% CI) 1.58-5.55], P < 0.00

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Targeting HER2 Exon 20 Insertion-Mutant Lung Adenocarcinoma with a Novel Tyrosine Kinase Inhibitor Mobocertinib.
Han H, Li S, Chen T, Fitzgerald M, Liu S, Peng C, Tang KH, Cao S, Chouitar J, Wu J, Peng D, Deng J, Gao Z, Baker TE, Li F, Zhang H, Pan Y, Ding H, Hu H, Pyon V, Thakurdin C, Papadopoulos E, Tang S, Gonzalvez F, Chen H, Rivera VM, Brake R, Vincent S, Wong KK. Han H, et al. Cancer Res. 2021 Oct 15;81(20):5311-5324. doi: 10.1158/0008-5472.CAN-21-1526. Epub 2021 Aug 11. Cancer Res. 2021. PMID: 34380634 Free PMC article.
Mobocertinib had the lowest HER2 exon 20 insertion IC(50)/wild-type (WT) EGFR IC(50) ratio, indicating that mobocertinib displayed the best selectivity profile in these models. Also, mobocertinib showed strong inhibitory activity in HER2 exon 20(YVMA) allograft and patient …
Mobocertinib had the lowest HER2 exon 20 insertion IC(50)/wild-type (WT) EGFR IC(50) ratio, indicating that mobocertinib displayed the best …
Electrochemical exfoliation of graphene-like two-dimensional nanomaterials.
Yang Y, Hou H, Zou G, Shi W, Shuai H, Li J, Ji X. Yang Y, et al. Nanoscale. 2018 Dec 20;11(1):16-33. doi: 10.1039/c8nr08227h. Nanoscale. 2018. PMID: 30525147 Review.
Unlike zero-dimensional quantum dots, one-dimensional nanowires/nanorods, and three-dimensional networks or even their bulk counterparts, the charge carriers in two-dimensional (2D) materials are confined along the thickness while being allowed to move along the plane. They have …
Unlike zero-dimensional quantum dots, one-dimensional nanowires/nanorods, and three-dimensional networks or even their bulk counterparts, th …
Effect of Strong Intermolecular Interaction in 2D Inorganic Molecular Crystals.
Feng X, Peng X, Peng B, Li Z, Huang W, Yang S, Pei K, Sun Z, Huang F, Li H, Shuai Z, Zhai T. Feng X, et al. J Am Chem Soc. 2021 Dec 8;143(48):20192-20201. doi: 10.1021/jacs.1c08030. Epub 2021 Nov 15. J Am Chem Soc. 2021. PMID: 34780690
Strong intermolecular interactions in 2D organic molecular crystals arising from pi-pi stacking have been widely explored to achieve high thermal stability, high carrier mobility, and novel physical properties, which have already produced phenomenal progress. ...Here, the …
Strong intermolecular interactions in 2D organic molecular crystals arising from pi-pi stacking have been widely explored to achieve …
Intermolecular Charge-Transfer-Induced Strong Optical Emission from Herringbone H-Aggregates.
Sun Q, Ren J, Jiang T, Peng Q, Ou Q, Shuai Z. Sun Q, et al. Nano Lett. 2021 Jun 23;21(12):5394-5400. doi: 10.1021/acs.nanolett.1c01734. Epub 2021 Jun 14. Nano Lett. 2021. PMID: 34125544
Taking intermolecular charge transfer and excitonic coupling into a three-state model through localized diabatization, we demonstrate that the low-lying intermolecular charge-transfer state could couple with the upper bright Frenkel exciton to form dipole-allowed S(1) that lies b …
Taking intermolecular charge transfer and excitonic coupling into a three-state model through localized diabatization, we demonstrate that t …
2-[2,6-Bis(pyrazin-2-yl)pyridin-4-yl]benzoic acid.
Shuai Y, Wang XY, Dai JW, Wu JZ. Shuai Y, et al. Acta Crystallogr Sect E Struct Rep Online. 2014 Apr 18;70(Pt 5):o577-8. doi: 10.1107/S1600536814008496. eCollection 2014 May 1. Acta Crystallogr Sect E Struct Rep Online. 2014. PMID: 24860380 Free PMC article.
In the title compound, C20H13N5O2, the two pyrazine rings are nearly coplanar with the central pyridine ring, forming dihedral angles of 2.21 (9) and 4.57 (9). In contrast, the strong steric hindrance caused by the ortho-carboxyl group on the phenyl ring makes this ring ro …
In the title compound, C20H13N5O2, the two pyrazine rings are nearly coplanar with the central pyridine ring, forming dihedral angles of 2.2 …
Structure, Properties and Applications of Two-Dimensional Hexagonal Boron Nitride.
Roy S, Zhang X, Puthirath AB, Meiyazhagan A, Bhattacharyya S, Rahman MM, Babu G, Susarla S, Saju SK, Tran MK, Sassi LM, Saadi MASR, Lai J, Sahin O, Sajadi SM, Dharmarajan B, Salpekar D, Chakingal N, Baburaj A, Shuai X, Adumbumkulath A, Miller KA, Gayle JM, Ajnsztajn A, Prasankumar T, Harikrishnan VVJ, Ojha V, Kannan H, Khater AZ, Zhu Z, Iyengar SA, Autreto PADS, Oliveira EF, Gao G, Birdwell AG, Neupane MR, Ivanov TG, Taha-Tijerina J, Yadav RM, Arepalli S, Vajtai R, Ajayan PM. Roy S, et al. Adv Mater. 2021 Nov;33(44):e2101589. doi: 10.1002/adma.202101589. Epub 2021 Sep 24. Adv Mater. 2021. PMID: 34561916 Review.
Hexagonal boron nitride (h-BN) has emerged as a strong candidate for two-dimensional (2D) material owing to its exciting optoelectrical properties combined with mechanical robustness, thermal stability, and chemical inertness. ...
Hexagonal boron nitride (h-BN) has emerged as a strong candidate for two-dimensional (2D) material owing to its exciting optoelectric …
The Drosophila Mushroom Body: From Architecture to Algorithm in a Learning Circuit.
Modi MN, Shuai Y, Turner GC. Modi MN, et al. Annu Rev Neurosci. 2020 Jul 8;43:465-484. doi: 10.1146/annurev-neuro-080317-0621333. Epub 2020 Apr 13. Annu Rev Neurosci. 2020. PMID: 32283995 Review.
Recent advances have established a clear framework for Drosophila learning and revealed the following key operations: a) pattern separation, whereby dense combinatorial representations of odors are preprocessed to generate highly specific, nonoverlapping odor patterns used for le …
Recent advances have established a clear framework for Drosophila learning and revealed the following key operations: a) pattern separation, …
Design, Synthesis, and Antitumor Activity of Potent and Selective EGFR L858R/T790M Inhibitors and Identification of a Combination Therapy to Overcome Acquired Resistance in Models of Non-small-cell Lung Cancer.
Pei J, Wang G, Wang A, Wu C, Pan X, Shuai W, Bu F, Zhu Y, Wang Y, Ouyang L, Li W. Pei J, et al. J Med Chem. 2023 Apr 27;66(8):5719-5752. doi: 10.1021/acs.jmedchem.3c00027. Epub 2023 Apr 12. J Med Chem. 2023. PMID: 37042119
Here, we report the identification, structure optimization, and structure-activity relationship studies of quinazoline derivatives as novel selective EGFR L858R/T790M inhibitors. The most promising compound, 28f, exhibited strong inhibitory activity against EGFR L858R/T790 …
Here, we report the identification, structure optimization, and structure-activity relationship studies of quinazoline derivatives as novel …
151 results