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2013 1
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2020 2
2021 1
2022 3
2023 3
2024 2

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15 results

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Page 1
Single-cell analysis reveals inflammatory interactions driving macular degeneration.
Kuchroo M, DiStasio M, Song E, Calapkulu E, Zhang L, Ige M, Sheth AH, Majdoubi A, Menon M, Tong A, Godavarthi A, Xing Y, Gigante S, Steach H, Huang J, Huguet G, Narain J, You K, Mourgkos G, Dhodapkar RM, Hirn MJ, Rieck B, Wolf G, Krishnaswamy S, Hafler BP. Kuchroo M, et al. Nat Commun. 2023 May 5;14(1):2589. doi: 10.1038/s41467-023-37025-7. Nat Commun. 2023. PMID: 37147305 Free PMC article.
Due to commonalities in pathophysiology, age-related macular degeneration (AMD) represents a uniquely accessible model to investigate therapies for neurodegenerative diseases, leading us to examine whether pathways of disease progression are shared across neurodegenerative …
Due to commonalities in pathophysiology, age-related macular degeneration (AMD) represents a uniquely accessible model to investigate therap …
Recovering Gene Interactions from Single-Cell Data Using Data Diffusion.
van Dijk D, Sharma R, Nainys J, Yim K, Kathail P, Carr AJ, Burdziak C, Moon KR, Chaffer CL, Pattabiraman D, Bierie B, Mazutis L, Wolf G, Krishnaswamy S, Pe'er D. van Dijk D, et al. Cell. 2018 Jul 26;174(3):716-729.e27. doi: 10.1016/j.cell.2018.05.061. Epub 2018 Jun 28. Cell. 2018. PMID: 29961576 Free PMC article.
To address this, we developed MAGIC (Markov affinity-based graph imputation of cells), a method that shares information across similar cells, via data diffusion, to denoise the cell count matrix and fill in missing transcripts. ...
To address this, we developed MAGIC (Markov affinity-based graph imputation of cells), a method that shares information across simila …
Early molecular layer interneuron hyperactivity triggers Purkinje neuron degeneration in SCA1.
Pilotto F, Douthwaite C, Diab R, Ye X, Al Qassab Z, Tietje C, Mounassir M, Odriozola A, Thapa A, Buijsen RAM, Lagache S, Uldry AC, Heller M, Müller S, van Roon-Mom WMC, Zuber B, Liebscher S, Saxena S. Pilotto F, et al. Neuron. 2023 Aug 16;111(16):2523-2543.e10. doi: 10.1016/j.neuron.2023.05.016. Epub 2023 Jun 14. Neuron. 2023. PMID: 37321222 Free PMC article.
Chronic inhibition of mutant MLINs delayed PN degeneration, reduced pathology, and ameliorated motor deficits in Sca1 mice. Conserved proteomic signature of Sca1 MLINs, shared with human SCA1 interneurons, involved the higher expression of FRRS1L, implicated in AMPA recept …
Chronic inhibition of mutant MLINs delayed PN degeneration, reduced pathology, and ameliorated motor deficits in Sca1 mice. Conserved proteo …
Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states.
Callahan D, Smita S, Joachim S, Hoehn K, Kleinstein S, Weisel F, Chikina M, Shlomchik M. Callahan D, et al. Nat Immunol. 2024 Mar;25(3):562-575. doi: 10.1038/s41590-023-01721-9. Epub 2024 Jan 10. Nat Immunol. 2024. PMID: 38200277
Chromatin and transcriptional profiling revealed similarity of DN cells with an early memory precursor. Reciprocally, GCBC-derived DP cells shared distinct genomic features with GCBCs, while DP(EX) cells had hybrid features. ...
Chromatin and transcriptional profiling revealed similarity of DN cells with an early memory precursor. Reciprocally, GCBC-derived DP cells …
Systematic evidence review and meta-analysis of outcomes associated with cancer genetic counseling.
Culver JO, Bertsch NL, Kurz RN, Cheng LL, Pritzlaff M, Rao SK, Stasi SM, Stave CD, Sharaf RN. Culver JO, et al. Genet Med. 2024 Jan;26(1):100980. doi: 10.1016/j.gim.2023.100980. Epub 2023 Sep 6. Genet Med. 2024. PMID: 37688462 Review.
No included studies elucidated GC effect on mortality, cascade testing, cost-effectiveness, care coordination, shared decision making, or patient time burden. CONCLUSION: The true impact of GC on relevant outcomes is not known low quality or absent evidence. ...
No included studies elucidated GC effect on mortality, cascade testing, cost-effectiveness, care coordination, shared decision making …
Attempts to replicate genetic associations with schizophrenia in a cohort from north India.
Prasad S, Bhatia T, Kukshal P, Nimgaonkar VL, Deshpande SN, Thelma BK. Prasad S, et al. NPJ Schizophr. 2017 Aug 30;3(1):28. doi: 10.1038/s41537-017-0030-8. NPJ Schizophr. 2017. PMID: 28855605 Free PMC article.
This relative lack of significant positive associations is likely influenced by the sample size and/or differences in the genetic architecture of schizophrenia across populations, encouraging population specific studies to identify shared and unique genetic risk factors fo …
This relative lack of significant positive associations is likely influenced by the sample size and/or differences in the genetic architectu …
Safety and efficacy of HSP90 inhibitor ganetespib for neoadjuvant treatment of stage II/III breast cancer.
Lang JE, Forero-Torres A, Yee D, Yau C, Wolf D, Park J, Parker BA, Chien AJ, Wallace AM, Murthy R, Albain KS, Ellis ED, Beckwith H, Haley BB, Elias AD, Boughey JC, Yung RL, Isaacs C, Clark AS, Han HS, Nanda R, Khan QJ, Edmiston KK, Stringer-Reasor E, Price E, Joe B, Liu MC, Brown-Swigart L, Petricoin EF, Wulfkuhle JD, Buxton M, Clennell JL, Sanil A, Berry S, Asare SM, Wilson A, Hirst GL, Singhrao R, Asare AL, Matthews JB, Melisko M, Perlmutter J, Rugo HS, Symmans WF, van 't Veer LJ, Hylton NM, DeMichele AM, Berry DA, Esserman LJ. Lang JE, et al. NPJ Breast Cancer. 2022 Dec 1;8(1):128. doi: 10.1038/s41523-022-00493-z. NPJ Breast Cancer. 2022. PMID: 36456573 Free PMC article.
Phylotaxogenomics for the Reappraisal of the Genus Roseomonas With the Creation of Six New Genera.
Rai A, Jagadeeshwari U, Deepshikha G, Smita N, Sasikala C, Ramana CV. Rai A, et al. Front Microbiol. 2021 Aug 13;12:677842. doi: 10.3389/fmicb.2021.677842. eCollection 2021. Front Microbiol. 2021. PMID: 34484138 Free PMC article.
The pan-genome evaluation depicted that the pan-genome was an open type and the members shared 958 core genes. This claim of reclassification was equally supported by the phenotypic and chemotaxonomic differences between the groups. ...
The pan-genome evaluation depicted that the pan-genome was an open type and the members shared 958 core genes. This claim of reclassi …
Geriatrics communication skills training program for oncology healthcare providers to improve the management of care for older adults with cancer.
Rosa WE, Cannity K, Moreno A, Cardillo C, Schofield EA, Korc-Grodzicki B, Parker PA, Manna R, Alici Y, Nelson C, Alexander K, Banerjee SC. Rosa WE, et al. PEC Innov. 2022 Dec;1:100066. doi: 10.1016/j.pecinn.2022.100066. Epub 2022 Jul 20. PEC Innov. 2022. PMID: 36741338 Free PMC article.
METHODS: Three 2-h modules comprised the training: Geriatrics 101, Cognitive Syndromes, and Shared Decision-Making. Modules consisted of didactic knowledge, exemplary videos, and experiential learning role plays with standardized patients. ...
METHODS: Three 2-h modules comprised the training: Geriatrics 101, Cognitive Syndromes, and Shared Decision-Making. Modules consisted …
Arenibacter lacus sp. nov., Isolated from Chilika Lagoon, India.
Kumar D, Smita N, Kumar G, Suresh G, Jagadeeshwari U, Sasikala C, Ramana CV. Kumar D, et al. Curr Microbiol. 2020 Dec;77(12):4152-4159. doi: 10.1007/s00284-020-02205-x. Epub 2020 Sep 21. Curr Microbiol. 2020. PMID: 32955652
Major polar lipids are phosphatidylethanolamine, phosphatidylcholine, a few unidentified phospholipids, and a few unidentified aminolipids. 16S rRNA gene sequencing showed that strain JC631(T) shared the highest sequence identity (98.7%) with Arenibacter latericius KMM 426 …
Major polar lipids are phosphatidylethanolamine, phosphatidylcholine, a few unidentified phospholipids, and a few unidentified aminolipids. …
15 results