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Carbon Black Nanoparticles Inhibit Aromatase Expression and Estradiol Secretion in Human Granulosa Cells Through the ERK1/2 Pathway.
Simon V, Avet C, Grange-Messent V, Wargnier R, Denoyelle C, Pierre A, Dairou J, Dupret JM, Cohen-Tannoudji J. Simon V, et al. Endocrinology. 2017 Oct 1;158(10):3200-3211. doi: 10.1210/en.2017-00374. Endocrinology. 2017. PMID: 28977593
In the current study, we investigated whether carbon black nanoparticles (CB NPs) affect the steroidogenic activity of cultured human granulosa cells. The human granulosa cell line KGN and granulosa cells from patients undergoing in vitro fertilization were treated …
In the current study, we investigated whether carbon black nanoparticles (CB NPs) affect the steroidogenic activity of cultured human granul …
Combined PPARγ Activation and XIAP Inhibition as a Potential Therapeutic Strategy for Ovarian Granulosa Cell Tumors.
Leung DTH, Nguyen T, Oliver EM, Matti J, Alexiadis M, Silke J, Jobling TW, Fuller PJ, Chu S. Leung DTH, et al. Mol Cancer Ther. 2019 Feb;18(2):364-375. doi: 10.1158/1535-7163.MCT-18-0078. Epub 2018 Dec 7. Mol Cancer Ther. 2019. PMID: 30530769
However, resistance to the actions of PPARgamma is caused by NFkappaB transrepression in GCT-derived cell lines, KGN and COV434. We showed that abrogation of NFkappaB signaling in GCT cells enables PPARgamma agonists to initiate apoptosis. ...Combined Smac-mimetic and TZD …
However, resistance to the actions of PPARgamma is caused by NFkappaB transrepression in GCT-derived cell lines, KGN and COV434. We s …