Erythrocyte transglutaminase-2 combats hypoxia and chronic kidney disease by promoting oxygen delivery and carnitine homeostasis.
Xu P, Chen C, Zhang Y, Dzieciatkowska M, Brown BC, Zhang W, Xie T, Abdulmalik O, Song A, Tong C, Qi H, Roach R, Kellems RE, D'Alessandro A, Xia Y.
Xu P, et al.
Cell Metab. 2022 Feb 1;34(2):299-316.e6. doi: 10.1016/j.cmet.2021.12.019.
Cell Metab. 2022.
PMID: 35108516
Free PMC article.
Here, we report that erythrocyte transglutminase-2 (eTG2)-mediated PTM is essential to trigger O(2) delivery by promoting bisphosphoglycerate mutase proteostasis and the Rapoport-Luebering glycolytic shunt for adaptation to hypoxia, in healthy humans ascending to high alti …
Here, we report that erythrocyte transglutminase-2 (eTG2)-mediated PTM is essential to trigger O(2) delivery by promoting bisphosphoglycerat …