Slc6a13 deficiency promotes Th17 responses during intestinal bacterial infection.
Ren W, Liao Y, Ding X, Jiang Y, Yan J, Xia Y, Tan B, Lin Z, Duan J, Jia X, Yang G, Deng J, Zhu C, Hardwidge PR, Li J, Zhu G, Yin Y.
Ren W, et al.
Mucosal Immunol. 2019 Mar;12(2):531-544. doi: 10.1038/s41385-018-0111-7. Epub 2018 Dec 6.
Mucosal Immunol. 2019.
PMID: 30523310
Free article.
Here we found that Th17 cells show higher abundance of GAT-2, and have distinct cellular metabolic signatures, such as the GABA shunt pathway, as compared to naive T cells. GAT-2 deficiency had little effect on the metabolic signature in naive T cells, but impaired the GAB …
Here we found that Th17 cells show higher abundance of GAT-2, and have distinct cellular metabolic signatures, such as the GABA shunt …