"Redirecting an anti-IL-1beta antibody to bind a new, unrelated and computationally predicted epitope on hIL-17A".
Fischman S, Levin I, Rondeau JM, Štrajbl M, Lehmann S, Huber T, Nimrod G, Cebe R, Omer D, Kovarik J, Bernstein S, Sasson Y, Demishtein A, Shlamkovich T, Bluvshtein O, Grossman N, Barak-Fuchs R, Zhenin M, Fastman Y, Twito S, Vana T, Zur N, Ofran Y.
Fischman S, et al.
Commun Biol. 2023 Sep 29;6(1):997. doi: 10.1038/s42003-023-05369-x.
Commun Biol. 2023.
PMID: 37773269
Free PMC article.
Using a small, focused library, we engineered AAL160, an anti-IL-1beta antibody, to bind the unrelated antigen IL-17A, with the introduction of seven mutations. The final redesigned antibody, 11.003, retains favorable biophysical properties, binds IL-17A with …
Using a small, focused library, we engineered AAL160, an anti-IL-1beta antibody, to bind the unrelated antigen IL-17A, with th …