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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 1
1986 2
1987 1
1988 2
1989 3
1990 4
1991 5
1992 6
1993 3
1994 2
1995 4
1996 6
1997 7
1998 13
1999 10
2000 6
2001 20
2002 17
2003 31
2004 26
2005 33
2006 56
2007 57
2008 77
2009 74
2010 126
2011 175
2012 217
2013 219
2014 222
2015 288
2016 278
2017 311
2018 368
2019 428
2020 505
2021 593
2022 680
2023 788
2024 335

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5,401 results

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Page 1
SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology.
Huang J, Wu C, Kloeber JA, Gao H, Gao M, Zhu Q, Chang Y, Zhao F, Guo G, Luo K, Dai H, Liu S, Huang Q, Kim W, Zhou Q, Zhu S, Wu Z, Tu X, Yin P, Deng M, Wang L, Yuan J, Lou Z. Huang J, et al. Mol Cell. 2023 Apr 6;83(7):1043-1060.e10. doi: 10.1016/j.molcel.2023.02.004. Epub 2023 Feb 27. Mol Cell. 2023. PMID: 36854302 Free PMC article.
Using super-resolution imaging, we find that SLFN5 binds to 53BP1 chromatin domains to assemble a higher-order microdomain architecture by driving damaged chromatin dynamics at both DSBs and deprotected telomeres. Mechanistically, we propose that 53BP1 topology is shaped b …
Using super-resolution imaging, we find that SLFN5 binds to 53BP1 chromatin domains to assemble a higher-order microdomain architecture by d …
mTOR-mediated metabolic reprogramming shapes distinct microglia functions in response to lipopolysaccharide and ATP.
Hu Y, Mai W, Chen L, Cao K, Zhang B, Zhang Z, Liu Y, Lou H, Duan S, Gao Z. Hu Y, et al. Glia. 2020 May;68(5):1031-1045. doi: 10.1002/glia.23760. Epub 2019 Dec 3. Glia. 2020. PMID: 31793691
Our study reveals a critical role for mTOR in the regulation of metabolic programming of microglia to shape their distinct functions under different states and shed light on the potential application of targeting metabolism to interfere with microglia-mediated neuroinflamm …
Our study reveals a critical role for mTOR in the regulation of metabolic programming of microglia to shape their distinct functions …
Recent Advances in 4D Bioprinting.
Yang Q, Gao B, Xu F. Yang Q, et al. Biotechnol J. 2020 Jan;15(1):e1900086. doi: 10.1002/biot.201900086. Epub 2019 Sep 20. Biotechnol J. 2020. PMID: 31486199 Review.
In this technique, the printed bioconstructs are able to change their shapes or functionalities when triggered by either internal or external stimuli. In 4D bioprinting, the materials with/without cells enable the spatial-temporal control of the shape and/or functio …
In this technique, the printed bioconstructs are able to change their shapes or functionalities when triggered by either internal or …
Shaping Tumor Microenvironment for Improving Nanoparticle Delivery.
Gao H. Gao H. Curr Drug Metab. 2016;17(8):731-736. doi: 10.2174/1389200217666160630203600. Curr Drug Metab. 2016. PMID: 27396754 Review.
RESULTS: In tumor, elevated interstitial fluid pressure, abnormal tumor vasculature, dense tumor extracellular matrix and elevated solid stress considerably hinder the extravasation and intratumor penetration of nanoparticles. Therefore, shaping the tumor microenvironment …
RESULTS: In tumor, elevated interstitial fluid pressure, abnormal tumor vasculature, dense tumor extracellular matrix and elevated solid str …
Sexual behavior shapes male genitourinary microbiome composition.
Toh E, Xing Y, Gao X, Jordan SJ, Batteiger TA, Batteiger BE, Van Der Pol B, Muzny CA, Gebregziabher N, Williams JA, Fortenberry LJ, Fortenberry JD, Dong Q, Nelson DE. Toh E, et al. Cell Rep Med. 2023 Mar 21;4(3):100981. doi: 10.1016/j.xcrm.2023.100981. Cell Rep Med. 2023. PMID: 36948151 Free PMC article.
Thus, the male urethra supports a simple core microbiome that is established independent of sexual exposures but can be re-shaped by vaginal sex. Overall, the results suggest that urogenital microbiology and sexual behavior are inexorably intertwined, and show that the mal …
Thus, the male urethra supports a simple core microbiome that is established independent of sexual exposures but can be re-shaped by …
Reinforcement Learning Control With Knowledge Shaping.
Gao X, Si J, Huang H. Gao X, et al. IEEE Trans Neural Netw Learn Syst. 2024 Mar;35(3):3156-3167. doi: 10.1109/TNNLS.2023.3243631. Epub 2024 Feb 29. IEEE Trans Neural Netw Learn Syst. 2024. PMID: 37027592
Toward this goal, we formalize knowledge transfer by expressing knowledge in the value function in our problem construct, which is referred to as reinforcement learning with knowledge shaping (RL-KS). Unlike most transfer learning studies that are empirical in nature, our …
Toward this goal, we formalize knowledge transfer by expressing knowledge in the value function in our problem construct, which is referred …
Structures and recognition modes of toll-like receptors.
Gao D, Li W. Gao D, et al. Proteins. 2017 Jan;85(1):3-9. doi: 10.1002/prot.25179. Epub 2016 Oct 24. Proteins. 2017. PMID: 27699870 Review.
Despite the differences in interaction areas of ligand with TLRs, the extracellular domains of TLRs all adopt horseshoe-shaped structures and the overall M-shape of the TLR-ligand complexes is strikingly similar. ...
Despite the differences in interaction areas of ligand with TLRs, the extracellular domains of TLRs all adopt horseshoe-shaped struct …
Excitatory nucleo-olivary pathway shapes cerebellar outputs for motor control.
Wang X, Liu Z, Angelov M, Feng Z, Li X, Li A, Yang Y, Gong H, Gao Z. Wang X, et al. Nat Neurosci. 2023 Aug;26(8):1394-1406. doi: 10.1038/s41593-023-01387-4. Epub 2023 Jul 20. Nat Neurosci. 2023. PMID: 37474638 Free PMC article.
Activating the excitatory nucleo-olivary pathway induces well-timed internal feedback complex spike signals in Purkinje cells to shape cerebellar outputs. Anatomical tracing reveals extensive axonal collaterals from the excitatory nucleo-olivary neurons to downstream motor …
Activating the excitatory nucleo-olivary pathway induces well-timed internal feedback complex spike signals in Purkinje cells to shape …
From sensing to shaping microbiota: insights into the role of NOD2 in intestinal homeostasis and progression of Crohn's disease.
Balasubramanian I, Gao N. Balasubramanian I, et al. Am J Physiol Gastrointest Liver Physiol. 2017 Jul 1;313(1):G7-G13. doi: 10.1152/ajpgi.00330.2016. Epub 2017 Apr 27. Am J Physiol Gastrointest Liver Physiol. 2017. PMID: 28450278 Free PMC article. Review.
In addition to sensing its specific bacterial components as a cytosolic pattern recognition receptor, NOD2 also appears to shape the colonization of intestinal microbiota. Activated NOD2 triggers downstream signaling cascades exampled by the NF-kappaB pathway to induce ant …
In addition to sensing its specific bacterial components as a cytosolic pattern recognition receptor, NOD2 also appears to shape the …
Application of single-cell multi-omics approaches in horticulture research.
Zhang J, Ahmad M, Gao H. Zhang J, et al. Mol Hortic. 2023 Sep 26;3(1):18. doi: 10.1186/s43897-023-00067-y. Mol Hortic. 2023. PMID: 37789394 Free PMC article. Review.
Cell heterogeneity shapes the morphology and function of various tissues and organs in multicellular organisms. ...
Cell heterogeneity shapes the morphology and function of various tissues and organs in multicellular organisms. ...
5,401 results