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TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content.
Mahdessian H, Taxiarchis A, Popov S, Silveira A, Franco-Cereceda A, Hamsten A, Eriksson P, van't Hooft F. Mahdessian H, et al. Among authors: popov s. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8913-8. doi: 10.1073/pnas.1323785111. Epub 2014 Jun 4. Proc Natl Acad Sci U S A. 2014. PMID: 24927523 Free PMC article.
Genome-wide association studies have identified a locus on chromosome 19 associated with plasma triglyceride (TG) concentration and nonalcoholic fatty liver disease. However, the identity and functional role of the gene(s) responsible for these associations remain unknown. …
Genome-wide association studies have identified a locus on chromosome 19 associated with plasma triglyceride (TG) concentration and nonalcoh …
Lack of salt-inducible kinase 2 (SIK2) prevents the development of cardiac hypertrophy in response to chronic high-salt intake.
Popov S, Takemori H, Tokudome T, Mao Y, Otani K, Mochizuki N, Pires N, Pinho MJ, Franco-Cereceda A, Torielli L, Ferrandi M, Hamsten A, Soares-da-Silva P, Eriksson P, Bertorello AM, Brion L. Popov S, et al. PLoS One. 2014 Apr 21;9(4):e95771. doi: 10.1371/journal.pone.0095771. eCollection 2014. PLoS One. 2014. PMID: 24752134 Free PMC article.
Salt-inducible kinase 1 influences Na(+),K(+)-ATPase activity in vascular smooth muscle cells and associates with variations in blood pressure.
Popov S, Silveira A, Wågsäter D, Takemori H, Oguro R, Matsumoto S, Sugimoto K, Kamide K, Hirose T, Satoh M, Metoki H, Kikuya M, Ohkubo T, Katsuya T, Rakugi H, Imai Y, Sanchez F, Leosdottir M, Syvänen AC, Hamsten A, Melander O, Bertorello AM. Popov S, et al. J Hypertens. 2011 Dec;29(12):2395-403. doi: 10.1097/HJH.0b013e32834d3d55. J Hypertens. 2011. PMID: 22045124
Increases in intracellular sodium activate transcription and gene expression via the salt-inducible kinase 1 network in an atrial myocyte cell line.
Popov S, Venetsanou K, Chedrese PJ, Pinto V, Takemori H, Franco-Cereceda A, Eriksson P, Mochizuki N, Soares-da-Silva P, Bertorello AM. Popov S, et al. Am J Physiol Heart Circ Physiol. 2012 Jul;303(1):H57-65. doi: 10.1152/ajpheart.00512.2011. Epub 2012 Mar 30. Am J Physiol Heart Circ Physiol. 2012. PMID: 22467310 Free article.