Decitabine mildly attenuates MLL-rearranged acute lymphoblastic leukemia in vivo, and represents a poor chemo-sensitizer.
Schneider P, Castro PG, Pinhanços SM, Kerstjens M, van Roon EH, Essing AHW, Dolman MEM, Molenaar JJ, Pieters R, Stam RW.
Schneider P, et al.
EJHaem. 2020 Aug 24;1(2):527-536. doi: 10.1002/jha2.81. eCollection 2020 Nov.
EJHaem. 2020.
PMID: 35844991
Free PMC article.
Our data reveal that decitabine prolonged survival in xenograft mice of MLL-rearranged ALL by 8.5 days (P = .0181), but eventually was insufficient to prevent leukemia out-growth, based on the examination of the MLLAF4 cell line SEM. Furthermore, we observe that prolonged …
Our data reveal that decitabine prolonged survival in xenograft mice of MLL-rearranged ALL by 8.5 days (P = .0181), but eventually was insuf …