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Did you mean seo chan won (12 results)?
A novel pyrazolo [3,4-d] pyrimidine, KKC080106, activates the Nrf2 pathway and protects nigral dopaminergic neurons.
Lee JA, Kim HR, Son HJ, Shin N, Han SH, Cheong CS, Kim DJ, Hwang O. Lee JA, et al. Exp Neurol. 2020 Oct;332:113387. doi: 10.1016/j.expneurol.2020.113387. Epub 2020 Jun 21. Exp Neurol. 2020. PMID: 32580013
The transcription factor nuclear factor-erythroid 2-related factor-2 (Nrf2) is known to induce neuroprotective and anti-inflammatory effects and is considered to be an excellent molecular target for drugs related to neurodegenerative disease therapy. ...KKC080106 was able …
The transcription factor nuclear factor-erythroid 2-related factor-2 (Nrf2) is known to induce neuroprotective and anti-inflammatory …
Anti-Inflammatory Effects of Antarctic Lichen Umbilicaria antarctica Methanol Extract in Lipopolysaccharide-Stimulated RAW 264.7 Macrophage Cells and Zebrafish Model.
Hong JM, Kim JE, Min SK, Kim KH, Han SJ, Yim JH, Park H, Kim JH, Kim IC. Hong JM, et al. Biomed Res Int. 2021 Feb 16;2021:8812090. doi: 10.1155/2021/8812090. eCollection 2021. Biomed Res Int. 2021. PMID: 33644231 Free PMC article.
Umbilicaria antarctica (UA) is a member of the family Umbilicariaceae. To the best of our knowledge, no studies on its anti-inflammatory effects have been reported yet. ...It also suppressed the mRNA and protein expression of inducible nitric oxide synthase (iNOS), cycloox …
Umbilicaria antarctica (UA) is a member of the family Umbilicariaceae. To the best of our knowledge, no studies on its anti-inflammat …
Activation of the Nrf2 signaling pathway and neuroprotection of nigral dopaminergic neurons by a novel synthetic compound KMS99220.
Lee JA, Son HJ, Choi JW, Kim J, Han SH, Shin N, Kim JH, Kim SJ, Heo JY, Kim DJ, Park KD, Hwang O. Lee JA, et al. Neurochem Int. 2018 Jan;112:96-107. doi: 10.1016/j.neuint.2017.11.006. Epub 2017 Nov 20. Neurochem Int. 2018. PMID: 29158022
It showed high binding affinity to the Nrf2 inhibitory protein Keap-1 and increased nuclear translocation of Nrf2 and gene expression of the antioxidant enzymes heme oxygenase-1, NAD(P)H:quinone oxidoreductase-1, and the catalytic and modifier subunits of glutamate-cystein …
It showed high binding affinity to the Nrf2 inhibitory protein Keap-1 and increased nuclear translocation of Nrf2 and gene expression …
A Novel Compound ITC-3 Activates the Nrf2 Signaling and Provides Neuroprotection in Parkinson's Disease Models.
Lee JA, Son HJ, Park KD, Han SH, Shin N, Kim JH, Kim HR, Kim DJ, Hwang O. Lee JA, et al. Neurotox Res. 2015 Nov;28(4):332-45. doi: 10.1007/s12640-015-9550-z. Epub 2015 Aug 2. Neurotox Res. 2015. PMID: 26233727
In the present study, we aimed at protecting the DAergic neurons by suppressing these cellular events and generated a novel synthetic isothiocyanate ITC-3. The compound led to elevation of nuclear and total levels of the transcription factor Nrf2 and interacted with its bi …
In the present study, we aimed at protecting the DAergic neurons by suppressing these cellular events and generated a novel synthetic isothi …
2-Acetyl-7-hydroxy-6-methoxy-1-methyl-1,2,3,4,-tetrahydroisoquinoline exhibits anti-inflammatory properties and protects the nigral dopaminergic neurons.
Son HJ, Han SH, Lee JA, Lee CS, Seo JW, Chi DY, Hwang O. Son HJ, et al. Eur J Pharmacol. 2016 Jan 15;771:152-61. doi: 10.1016/j.ejphar.2015.12.009. Epub 2015 Dec 11. Eur J Pharmacol. 2016. PMID: 26687634
AMTIQ also repressed gene expression of the proinflammatory cytokines IL-1beta and TNF-alpha, and attenuated nuclear translocation of NF-kappaB. AMTIQ was stable against liver microsomal enzymes from human and mouse and did not interfere with activities of the cytochrome p …
AMTIQ also repressed gene expression of the proinflammatory cytokines IL-1beta and TNF-alpha, and attenuated nuclear translocation of …
A novel compound VSC2 has anti-inflammatory and antioxidant properties in microglia and in Parkinson's disease animal model.
Lee JA, Kim JH, Woo SY, Son HJ, Han SH, Jang BK, Choi JW, Kim DJ, Park KD, Hwang O. Lee JA, et al. Br J Pharmacol. 2015 Feb;172(4):1087-100. doi: 10.1111/bph.12973. Epub 2014 Dec 15. Br J Pharmacol. 2015. PMID: 25297649 Free PMC article.
It also down-regulated expression of inducible NOS (iNOS), COX-2, IL-1beta and TNF-alpha and inhibited nuclear translocalization and transcriptional activity of NF-kappaB. VSC2 increased total and nuclear Nrf2 levels, induced Nrf2 transcriptional activity and was bo …
It also down-regulated expression of inducible NOS (iNOS), COX-2, IL-1beta and TNF-alpha and inhibited nuclear translocalization and …