Abstract
Natural steroids and triterpenes such as b-sitosterol, stigmasterol, lupeol, ursolic and betulinic acids were transformed into its hexanoic and oleic esters, to evaluate the influence of chemical modification towards the cytotoxic activities against tumor cells. The derivatives were evaluated against five tumor cell lines [OVCAR-8 (ovarian carcinoma); SF-295 (glioblastoma); HCT-116 (colon adenocarcinoma); HL-60 (leukemia); and PC-3 (prostate carcinoma)] and the results showed only betulinic acid hexyl ester exhibits cytotoxic potential activity.
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Betulinic Acid
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Cell Line, Tumor
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Drug Screening Assays, Antitumor
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Esters
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Fabaceae / chemistry*
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Fabaceae / classification
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Humans
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Inhibitory Concentration 50
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Lamiaceae / chemistry*
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Lamiaceae / classification
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Pentacyclic Triterpenes / chemistry
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Pentacyclic Triterpenes / isolation & purification
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Pentacyclic Triterpenes / pharmacology*
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Triterpenes / chemistry
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Triterpenes / isolation & purification
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Triterpenes / pharmacology*
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Ursolic Acid
Substances
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Antineoplastic Agents
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Esters
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Pentacyclic Triterpenes
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Triterpenes
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lupeol
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Betulinic Acid