Permanent tissue damage in multiple sclerosis lesions is associated with reduced pre-lesion myelin and axon volume fractions.
Tagge IJ, Leppert IR, Fetco D, Campbell JS, Rudko DA, Brown RA, Stikov N, Pike GB, Giacomini PS, Arnold DL, Narayanan S.
Tagge IJ, et al.
Mult Scler. 2022 Nov;28(13):2027-2037. doi: 10.1177/13524585221110585. Epub 2022 Jul 28.
Mult Scler. 2022.
PMID: 35903888
Free PMC article.
It has not yet been determined if, or how, pre-lesional abnormalities in normal-appearing white matter (NAWM) relate to the long-term evolution of new lesions. OBJECTIVE: To investigate the relationship between abnormalities in MRI measures of axonal and myelin volume frac …
It has not yet been determined if, or how, pre-lesional abnormalities in normal-appearing white matter (NAWM) relate to the long-term …