Abstract
The global epidemiologic burden of sepsis is difficult to ascertain. Sepsis affects more than 31.5 million people worldwide every year, potentially resulting in 5 million deaths. Up to one-third of patients with sepsis also develop sepsis-associated acute kidney injury. This article describes the need for restraint in fluid resuscitation in patients with sepsis, in order to mitigate end-organ damage and ultimately to save lives.
MeSH terms
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Acute Kidney Injury / etiology*
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Anti-Bacterial Agents / therapeutic use
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Bacteremia / complications
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Bacteremia / therapy
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Diabetes Mellitus, Type 2 / complications
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Endocarditis, Bacterial / complications
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Endocarditis, Bacterial / therapy*
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Enterococcus faecalis
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Fatal Outcome
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Fluid Therapy / adverse effects*
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Fluid Therapy / methods
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Gram-Positive Bacterial Infections / complications
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Gram-Positive Bacterial Infections / therapy*
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Heart Failure / complications
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Humans
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Intra-Abdominal Hypertension / etiology
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Intra-Abdominal Hypertension / surgery
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Male
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Middle Aged
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Renal Insufficiency, Chronic / complications
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Respiratory Insufficiency / etiology*
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Sepsis / complications
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Sepsis / therapy*
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Shock, Cardiogenic / etiology*
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Water-Electrolyte Imbalance / etiology*