Preventing kidney injury by avoiding fluid overload in patients with sepsis

JAAPA. 2019 Dec;32(12):40-45. doi: 10.1097/01.JAA.0000604904.81228.18.

Abstract

The global epidemiologic burden of sepsis is difficult to ascertain. Sepsis affects more than 31.5 million people worldwide every year, potentially resulting in 5 million deaths. Up to one-third of patients with sepsis also develop sepsis-associated acute kidney injury. This article describes the need for restraint in fluid resuscitation in patients with sepsis, in order to mitigate end-organ damage and ultimately to save lives.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acute Kidney Injury / etiology*
  • Anti-Bacterial Agents / therapeutic use
  • Bacteremia / complications
  • Bacteremia / therapy
  • Diabetes Mellitus, Type 2 / complications
  • Endocarditis, Bacterial / complications
  • Endocarditis, Bacterial / therapy*
  • Enterococcus faecalis
  • Fatal Outcome
  • Fluid Therapy / adverse effects*
  • Fluid Therapy / methods
  • Gram-Positive Bacterial Infections / complications
  • Gram-Positive Bacterial Infections / therapy*
  • Heart Failure / complications
  • Humans
  • Intra-Abdominal Hypertension / etiology
  • Intra-Abdominal Hypertension / surgery
  • Male
  • Middle Aged
  • Renal Insufficiency, Chronic / complications
  • Respiratory Insufficiency / etiology*
  • Sepsis / complications
  • Sepsis / therapy*
  • Shock, Cardiogenic / etiology*
  • Water-Electrolyte Imbalance / etiology*

Substances

  • Anti-Bacterial Agents