Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 1
1987 6
1988 7
1989 12
1990 17
1991 11
1992 11
1993 8
1994 9
1995 10
1996 12
1997 13
1998 21
1999 16
2000 12
2001 21
2002 24
2003 32
2004 21
2005 36
2006 40
2007 41
2008 37
2009 35
2010 45
2011 48
2012 47
2013 49
2014 76
2015 133
2016 135
2017 130
2018 141
2019 156
2020 122
2021 114
2022 81
2023 88
2024 32

Text availability

Article attribute

Article type

Publication date

Search Results

1,634 results

Results by year

Filters applied: . Clear all
Page 1
Mechanisms and pathology of protein misfolding and aggregation.
Louros N, Schymkowitz J, Rousseau F. Louros N, et al. Nat Rev Mol Cell Biol. 2023 Dec;24(12):912-933. doi: 10.1038/s41580-023-00647-2. Epub 2023 Sep 8. Nat Rev Mol Cell Biol. 2023. PMID: 37684425 Review.
Despite advances in machine learning-based protein structure prediction, we are still far from fully understanding how proteins fold into their native conformation. ...Here, we review the current understanding of how intrinsic protein conformational propensit …
Despite advances in machine learning-based protein structure prediction, we are still far from fully understanding how proteins …
The Biology of Huntingtin.
Saudou F, Humbert S. Saudou F, et al. Neuron. 2016 Mar 2;89(5):910-26. doi: 10.1016/j.neuron.2016.02.003. Neuron. 2016. PMID: 26938440 Free article. Review.
Huntingtin (HTT) is now a famous protein because an abnormal expansion of a glutamine stretch (polyQ) in its N-terminal sequence leads to the devastating neurodegenerative disorder Huntington's disease (HD). ...Notwithstanding with the value of this approach, evidence has …
Huntingtin (HTT) is now a famous protein because an abnormal expansion of a glutamine stretch (polyQ) in its N-terminal sequence lead …
Protein structure and aggregation: a marriage of necessity ruled by aggregation gatekeepers.
Houben B, Rousseau F, Schymkowitz J. Houben B, et al. Trends Biochem Sci. 2022 Mar;47(3):194-205. doi: 10.1016/j.tibs.2021.08.010. Epub 2021 Sep 22. Trends Biochem Sci. 2022. PMID: 34561149 Review.
Protein aggregation propensity is a pervasive and seemingly inescapable property of proteomes. Strikingly, a significant fraction of the proteome is supersaturated, meaning that, for these proteins, their native conformation is less stable than the aggregated state. …
Protein aggregation propensity is a pervasive and seemingly inescapable property of proteomes. Strikingly, a significant fraction of …
[Biomarker, what is the pathologist's role?].
Bibeau F. Bibeau F. Ann Pathol. 2019 Jun;39(3):177-178. doi: 10.1016/j.annpat.2019.05.002. Ann Pathol. 2019. PMID: 31160017 French. No abstract available.
Mechanical stimuli control liver homeostasis.
Lemaigre FP. Lemaigre FP. J Hepatol. 2019 Jul;71(1):12-13. doi: 10.1016/j.jhep.2019.04.002. Epub 2019 Apr 26. J Hepatol. 2019. PMID: 31036351 No abstract available.
Early-onset autoimmunity associated with SOCS1 haploinsufficiency.
Hadjadj J, Castro CN, Tusseau M, Stolzenberg MC, Mazerolles F, Aladjidi N, Armstrong M, Ashrafian H, Cutcutache I, Ebetsberger-Dachs G, Elliott KS, Durieu I, Fabien N, Fusaro M, Heeg M, Schmitt Y, Bras M, Knight JC, Lega JC, Lesca G, Mathieu AL, Moreews M, Moreira B, Nosbaum A, Page M, Picard C, Ronan Leahy T, Rouvet I, Ryan E, Sanlaville D, Schwarz K, Skelton A, Viallard JF, Viel S, Villard M, Callebaut I, Picard C, Walzer T, Ehl S, Fischer A, Neven B, Belot A, Rieux-Laucat F. Hadjadj J, et al. Nat Commun. 2020 Oct 21;11(1):5341. doi: 10.1038/s41467-020-18925-4. Nat Commun. 2020. PMID: 33087723 Free PMC article.
Here, by whole-exome/genome sequencing we identify heterozygous, autosomal-dominant, germline loss-of-function mutations in the SOCS1 gene in ten patients from five unrelated families with early onset autoimmune manifestations. The intracellular protein SOCS1 is known to d …
Here, by whole-exome/genome sequencing we identify heterozygous, autosomal-dominant, germline loss-of-function mutations in the SOCS1 gene i …
NBEAL2 deficiency in humans leads to low CTLA-4 expression in activated conventional T cells.
Delage L, Carbone F, Riller Q, Zachayus JL, Kerbellec E, Buzy A, Stolzenberg MC, Luka M, de Cevins C, Kalouche G, Favier R, Michel A, Meynier S, Corneau A, Evrard C, Neveux N, Roudières S, Pérot BP, Fusaro M, Lenoir C, Pellé O, Parisot M, Bras M, Héritier S, Leverger G, Korganow AS, Picard C, Latour S, Collet B, Fischer A, Neven B, Magérus A, Ménager M, Pasquier B, Rieux-Laucat F. Delage L, et al. Nat Commun. 2023 Jun 22;14(1):3728. doi: 10.1038/s41467-023-39295-7. Nat Commun. 2023. PMID: 37349339 Free PMC article.
A proportion of patients with GPS develop autoimmunity through an unknown mechanism, which might be related to the proteins NBEAL2 interacts with, specifically in immune cells. Here we show a comprehensive interactome of NBEAL2 in primary T cells, based on mass spectrometr …
A proportion of patients with GPS develop autoimmunity through an unknown mechanism, which might be related to the proteins NBEAL2 in …
Postsynaptic Protein Shank3a Deficiency Synergizes with Alzheimer's Disease Neuropathology to Impair Cognitive Performance in the 3xTg-AD Murine Model.
Landry O, François A, Oye Mintsa Mi-Mba MF, Traversy MT, Tremblay C, Emond V, Bennett DA, Gylys KH, Buxbaum JD, Calon F. Landry O, et al. J Neurosci. 2023 Jun 28;43(26):4941-4954. doi: 10.1523/JNEUROSCI.1945-22.2023. Epub 2023 May 30. J Neurosci. 2023. PMID: 37253603 Free PMC article.
Synaptic loss is intrinsically linked to Alzheimer's disease (AD) neuropathology and symptoms, but its direct impact on clinical symptoms remains elusive. The postsynaptic protein Shank3 (SH3 and multiple ankyrin repeat domains) is of particular interest, as the loss of a …
Synaptic loss is intrinsically linked to Alzheimer's disease (AD) neuropathology and symptoms, but its direct impact on clinical symptoms re …
Multiscale Dynamic Structuring of Bacterial Chromosomes.
Lioy VS, Junier I, Boccard F. Lioy VS, et al. Annu Rev Microbiol. 2021 Oct 8;75:541-561. doi: 10.1146/annurev-micro-033021-113232. Epub 2021 Aug 3. Annu Rev Microbiol. 2021. PMID: 34343019 Review.
1,634 results