Role of l- and d-Menthol in the Glucuronidation and Detoxification of the Major Lung Carcinogen, NNAL.
Kozlovich S, Chen G, Watson CJW, Blot WJ, Lazarus P.
Kozlovich S, et al.
Drug Metab Dispos. 2019 Dec;47(12):1388-1396. doi: 10.1124/dmd.119.088351. Epub 2019 Oct 2.
Drug Metab Dispos. 2019.
PMID: 31578206
Free PMC article.
UGTs 1A9, 1A10, 2A1, 2A2, 2A3, 2B4, 2B7, and 2B17 all exhibited glucuronidating activity against both l- and d-menthol. In human liver microsomes, both l- and d-menthol inhibited the formation of each NNAL-Gluc, with a stereospecific difference observed between the formati …
UGTs 1A9, 1A10, 2A1, 2A2, 2A3, 2B4, 2B7, and 2B17 all exhibited glucuronidating activity against both l- and d-menthol. In human liver …