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Increased MCL1 dependency leads to new applications of BH3-mimetics in drug-resistant neuroblastoma.
Jacob M, Wiedemann S, Brücher D, Pieper NM, Birkhold M, Särchen V, Jeroch J, Demes MC, Gretser S, Braun Y, Gradhand E, Rothweiler F, Michaelis M, Cinatl J Jr, Vogler M. Jacob M, et al. Br J Cancer. 2023 Nov;129(10):1667-1678. doi: 10.1038/s41416-023-02430-8. Epub 2023 Sep 19. Br J Cancer. 2023. PMID: 37723317 Free PMC article.
CONCLUSIONS: These data highlight that the application of BH3-mimetics may differ between first line treatment and relapsed disease. Combination of NK cell-based immunotherapy with BH3-mimetics may further increase killing of chemoresistant neuroblastoma, outlining …
CONCLUSIONS: These data highlight that the application of BH3-mimetics may differ between first line treatment and relapsed disease. …
Loading of Coal Tar in Polymeric Nanoparticles as a Potential Therapeutic Modality for Psoriasis.
Sunoqrot S, Niazi M, Al-Natour MA, Jaber M, Abu-Qatouseh L. Sunoqrot S, et al. ACS Omega. 2022 Feb 18;7(8):7333-7340. doi: 10.1021/acsomega.1c07267. eCollection 2022 Mar 1. ACS Omega. 2022. PMID: 35252723 Free PMC article.
Permeation, washability, and staining experiments were carried out using skin-mimetic Strat-M membranes in Franz diffusion cells. The optimal CT-loaded PLGA NPs achieved 92% loading efficiency and were 133 nm in size with a polydispersity index (PDI) of 0.10 and a zeta pot …
Permeation, washability, and staining experiments were carried out using skin-mimetic Strat-M membranes in Franz diffusion cells. The …