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Nicotinamide-N-methyltransferase is a promising metabolic drug target for primary and metastatic clear cell renal cell carcinoma.
Reustle A, Menig LS, Leuthold P, Hofmann U, Stühler V, Schmees C, Becker M, Haag M, Klumpp V, Winter S, Büttner FA, Rausch S, Hennenlotter J, Fend F, Scharpf M, Stenzl A, Bedke J, Schwab M, Schaeffeler E. Reustle A, et al. Among authors: leuthold p. Clin Transl Med. 2022 Jun;12(6):e883. doi: 10.1002/ctm2.883. Clin Transl Med. 2022. PMID: 35678045 Free PMC article.
Novel drug transporter substrates identification: An innovative approach based on metabolomic profiling, in silico ligand screening and biological validation.
Nies AT, König J, Leuthold P, Damme K, Winter S, Haag M, Masuda S, Kruck S, Daniel H, Spanier B, Fromm MF, Bedke J, Inui KI, Schwab M, Schaeffeler E. Nies AT, et al. Among authors: leuthold p. Pharmacol Res. 2023 Oct;196:106941. doi: 10.1016/j.phrs.2023.106941. Epub 2023 Sep 27. Pharmacol Res. 2023. PMID: 37775020 Free article.
Molybdenum Cofactor Catabolism Unravels the Physiological Role of the Drug Metabolizing Enzyme Thiopurine S-Methyltransferase.
Pristup J, Schaeffeler E, Arjune S, Hofmann U, Angel Santamaria-Araujo J, Leuthold P, Friedrich N, Nauck M, Mayr S, Haag M, Muerdter T, Marner FJ, Relling MV, Evans WE, Schwarz G, Schwab M. Pristup J, et al. Among authors: leuthold p. Clin Pharmacol Ther. 2022 Oct;112(4):808-816. doi: 10.1002/cpt.2637. Epub 2022 May 31. Clin Pharmacol Ther. 2022. PMID: 35538648 Free PMC article.
Quantitative bile acid profiling by liquid chromatography quadrupole time-of-flight mass spectrometry: monitoring hepatitis B therapy by a novel Na(+)-taurocholate cotransporting polypeptide inhibitor.
Haag M, Hofmann U, Mürdter TE, Heinkele G, Leuthold P, Blank A, Haefeli WE, Alexandrov A, Urban S, Schwab M. Haag M, et al. Among authors: leuthold p. Anal Bioanal Chem. 2015 Sep;407(22):6815-25. doi: 10.1007/s00216-015-8853-5. Epub 2015 Jul 5. Anal Bioanal Chem. 2015. PMID: 26143062