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Nanomaterials in the Environment Acquire an "Eco-Corona" Impacting their Toxicity to Daphnia Magna-a Call for Updating Toxicity Testing Policies.
Nasser F, Constantinou J, Lynch I. Nasser F, et al. Proteomics. 2020 May;20(9):e1800412. doi: 10.1002/pmic.201800412. Epub 2019 Dec 6. Proteomics. 2020. PMID: 31750982 Review.
The eco-corona is not currently incorporated into ecotoxicity tests, although it has been shown to alter the interactions of NMs with organisms such as Daphnia magna (D. magna). Here, the literature on environmental biomolecule interactions with NMs is synthesized a …
The eco-corona is not currently incorporated into ecotoxicity tests, although it has been shown to alter the interactions of NMs with organi …
Secreted protein eco-corona mediates uptake and impacts of polystyrene nanoparticles on Daphnia magna.
Nasser F, Lynch I. Nasser F, et al. J Proteomics. 2016 Mar 30;137:45-51. doi: 10.1016/j.jprot.2015.09.005. Epub 2015 Sep 12. J Proteomics. 2016. PMID: 26376098 Free article.
We report here initial studies, including optimisation of protocols using carboxylic-acid and amino modified spherical polystyrene NPs, to assess interaction of NPs with biomolecules secreted by Daphnia magna and the impact of these interactions on NP uptake, retention and …
We report here initial studies, including optimisation of protocols using carboxylic-acid and amino modified spherical polystyrene NPs, to a …
Shape and Charge of Gold Nanomaterials Influence Survivorship, Oxidative Stress and Moulting of Daphnia magna.
Nasser F, Davis A, Valsami-Jones E, Lynch I. Nasser F, et al. Nanomaterials (Basel). 2016 Nov 25;6(12):222. doi: 10.3390/nano6120222. Nanomaterials (Basel). 2016. PMID: 28335350 Free PMC article.
Here we explore the effects of various shaped (spheres, rods) and charged (negative, positive) gold ENMs on Daphnia magna (D. magna) in terms of survival, ENM uptake and production of reactive oxygen species (ROS), a key factor in oxidative stress responses. We also …
Here we explore the effects of various shaped (spheres, rods) and charged (negative, positive) gold ENMs on Daphnia magna (D. magn …
Metabolomic method to detect a metabolite corona on amino-functionalized polystyrene nanoparticles.
Grintzalis K, Lawson TN, Nasser F, Lynch I, Viant MR. Grintzalis K, et al. Nanotoxicology. 2019 Aug;13(6):783-794. doi: 10.1080/17435390.2019.1577510. Epub 2019 May 16. Nanotoxicology. 2019. PMID: 31094641
We sought to determine whether a metabolite corona forms on NPs, using high-sensitivity metabolomics combined with a model system for freshwater ecotoxicology (Daphnia magna feeding on Chlorella vulgaris). Using amino-functionalized polystyrene NPs (NH(2)-pNPs), we showed …
We sought to determine whether a metabolite corona forms on NPs, using high-sensitivity metabolomics combined with a model system for freshw …