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Year Number of Results
1981 1
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1988 1
1991 2
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2023 3
2024 0

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17 results

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Page 1
Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma.
Jiang H, Greathouse RL, Tiche SJ, Zhao M, He B, Li Y, Li AM, Forgo B, Yip M, Li A, Shih M, Banuelos S, Zhou MN, Gruber JJ, Rankin EB, Hu Z, Shimada H, Chiu B, Ye J. Jiang H, et al. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029. Cancer Res. 2023. PMID: 36318118 Free PMC article.
In this study, we used a mitochondrial uncoupler, niclosamide ethanolamine (NEN), to activate mitochondrial respiration, which induced neural differentiation in neuroblastoma cells. NEN treatment increased the NAD+/NADH and pyruvate/lactate ratios and also the alpha …
In this study, we used a mitochondrial uncoupler, niclosamide ethanolamine (NEN), to activate mitochondrial respiration, which induced neura …
Non-covalent inhibitors of thioredoxin glutathione reductase with schistosomicidal activity in vivo.
Petukhova VZ, Aboagye SY, Ardini M, Lullo RP, Fata F, Byrne ME, Gabriele F, Martin LM, Harding LNM, Gone V, Dangi B, Lantvit DD, Nikolic D, Ippoliti R, Effantin G, Ling WL, Johnson JJ, Thatcher GRJ, Angelucci F, Williams DL, Petukhov PA. Petukhova VZ, et al. Nat Commun. 2023 Jun 22;14(1):3737. doi: 10.1038/s41467-023-39444-y. Nat Commun. 2023. PMID: 37349300 Free PMC article.
Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy.
Byrne NJ, Rajasekaran NS, Abel ED, Bugger H. Byrne NJ, et al. Free Radic Biol Med. 2021 Jun;169:317-342. doi: 10.1016/j.freeradbiomed.2021.03.046. Epub 2021 Apr 25. Free Radic Biol Med. 2021. PMID: 33910093 Free PMC article. Review.
There are several sources of ROS production including the mitochondria, NAD(P)H oxidase, xanthine oxidase, and uncoupled nitric oxide synthase. ...
There are several sources of ROS production including the mitochondria, NAD(P)H oxidase, xanthine oxidase, and uncoupled nitri …
A phase transition enhances the catalytic activity of SARM1, an NAD(+) glycohydrolase involved in neurodegeneration.
Loring HS, Czech VL, Icso JD, O'Connor L, Parelkar SS, Byrne AB, Thompson PR. Loring HS, et al. Elife. 2021 Jun 29;10:e66694. doi: 10.7554/eLife.66694. Elife. 2021. PMID: 34184985 Free PMC article.
Sterile alpha and toll/interleukin receptor (TIR) motif-containing protein 1 (SARM1) is a neuronally expressed NAD(+) glycohydrolase whose activity is increased in response to stress. NAD(+) depletion triggers axonal degeneration, which is a characteristic feature o …
Sterile alpha and toll/interleukin receptor (TIR) motif-containing protein 1 (SARM1) is a neuronally expressed NAD(+) glycohydrolase …
NAD+-associated-hyaluronic acid and poly(L-lysine) polyelectrolyte complexes: An evaluation of their potential for ocular drug delivery.
Casey-Power S, Vardar C, Ryan R, Behl G, McLoughlin P, Byrne ME, Fitzhenry L. Casey-Power S, et al. Eur J Pharm Biopharm. 2023 Nov;192:62-78. doi: 10.1016/j.ejpb.2023.10.004. Epub 2023 Oct 4. Eur J Pharm Biopharm. 2023. PMID: 37797681 Free article.
With a size of 235.1 19.0 nm, a PDI value of 0.214 0.140, and a zeta potential value of - 38.0 1.1 mV, the chosen PEC, loaded with 430 g of NAD+ per mg of PEC, exhibited non-Fickian, sustained release at physiological flowrates of 10.9 0.2 mg of NAD+ over 14 h …
With a size of 235.1 19.0 nm, a PDI value of 0.214 0.140, and a zeta potential value of - 38.0 1.1 mV, the chosen PEC, loaded with 430 g of …
Kinetic involvement of acetaldehyde substrate inhibition on the rate equation of yeast aldehyde dehydrogenase.
Eggert MW, Byrne ME, Chambers RP. Eggert MW, et al. Appl Biochem Biotechnol. 2012 Oct;168(4):824-33. doi: 10.1007/s12010-012-9822-5. Epub 2012 Aug 23. Appl Biochem Biotechnol. 2012. PMID: 22915233
The convenience of the statistical software package JMP allowed for effective determination of experimental kinetic constants and simplification to a suitable rate expression: v = Vmax(AB)/(K(ia)K(b) + K(b)A + K(a)B + AB + B(2)/K(I-Ald) + B(2)Q/K(I-Ald-NADH) + BQ/K(I-NA …
The convenience of the statistical software package JMP allowed for effective determination of experimental kinetic constants and simplifica …
Mitochondrial permeability transition in hepatocytes induced by t-BuOOH: NAD(P)H and reactive oxygen species.
Nieminen AL, Byrne AM, Herman B, Lemasters JJ. Nieminen AL, et al. Am J Physiol. 1997 Apr;272(4 Pt 1):C1286-94. doi: 10.1152/ajpcell.1997.272.4.C1286. Am J Physiol. 1997. PMID: 9142854
Trifluoperazine, which inhibits MPT, did not block the initial oxidation of NAD(P)H but prevented the second phase of oxidation, partially blocked ROS formation, and preserved cell viability. The antioxidants, deferoxamine and diphenylphenylenediamine, also prevente …
Trifluoperazine, which inhibits MPT, did not block the initial oxidation of NAD(P)H but prevented the second phase of oxidatio …
Mitochondrial myopathies: disorders of the respiratory chain and oxidative phosphorylation.
Clark JB, Hayes DJ, Morgan-Hughes JA, Byrne E. Clark JB, et al. J Inherit Metab Dis. 1984;7 Suppl 1:62-8. doi: 10.1007/BF03047377. J Inherit Metab Dis. 1984. PMID: 6434847
A defect in the NADH-CoQ reductase section of the respiratory chain was pinpointed possibly at an iron-sulphur centre. The fourth and fifth cases were two sisters who exhibited no lipid storage myopathy but whose mitochondrial activity was low with NAD-linked substr …
A defect in the NADH-CoQ reductase section of the respiratory chain was pinpointed possibly at an iron-sulphur centre. The fourth and …
17 results