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Year Number of Results
1997 2
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1999 1
2000 2
2001 1
2002 1
2003 1
2004 1
2006 1
2007 1
2008 1
2013 1
2014 1
2015 1
2016 1
2017 2
2022 1
2023 1
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22 results

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Page 1
Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment.
Wherry EJ, Blattman JN, Murali-Krishna K, van der Most R, Ahmed R. Wherry EJ, et al. J Virol. 2003 Apr;77(8):4911-27. doi: 10.1128/jvi.77.8.4911-4927.2003. J Virol. 2003. PMID: 12663797 Free PMC article.
Production of interleukin 2 and the ability to lyse target cells in vitro were the first functions compromised, followed by the ability to make tumor necrosis factor alpha, while gamma interferon production was most resistant to functional exhaustion. ...
Production of interleukin 2 and the ability to lyse target cells in vitro were the first functions compromised, followed by the ability to m …
Rapid demethylation of the IFN-gamma gene occurs in memory but not naive CD8 T cells.
Kersh EN, Fitzpatrick DR, Murali-Krishna K, Shires J, Speck SH, Boss JM, Ahmed R. Kersh EN, et al. J Immunol. 2006 Apr 1;176(7):4083-93. doi: 10.4049/jimmunol.176.7.4083. J Immunol. 2006. PMID: 16547244
Expression of the antiviral cytokine IFN-gamma in CD8 T cells is highly developmental stage specific. Most naive cells must divide before they express IFN-gamma, while memory cells vigorously express IFN-gamma before cell division. ...An inhibitor of methylat …
Expression of the antiviral cytokine IFN-gamma in CD8 T cells is highly developmental stage specific. Most naive cells must divide be …
IFN-gamma induces the erosion of preexisting CD8 T cell memory during infection with a heterologous intracellular bacterium.
Dudani R, Murali-Krishna K, Krishnan L, Sad S. Dudani R, et al. J Immunol. 2008 Aug 1;181(3):1700-9. doi: 10.4049/jimmunol.181.3.1700. J Immunol. 2008. PMID: 18641306 Free PMC article.
More importantly, erosion of preexisting memory CD8(+) T cells was abrogated in the absence of IFN-gamma. These studies help reveal the paradoxical role of IFN-gamma. Although IFN-gamma promotes the control of intracellular bacterial replication during primar …
More importantly, erosion of preexisting memory CD8(+) T cells was abrogated in the absence of IFN-gamma. These studies help reveal t …
IL-12 and type-I IFN synergize for IFN-gamma production by CD4 T cells, whereas neither are required for IFN-gamma production by CD8 T cells after Listeria monocytogenes infection.
Way SS, Havenar-Daughton C, Kolumam GA, Orgun NN, Murali-Krishna K. Way SS, et al. J Immunol. 2007 Apr 1;178(7):4498-505. doi: 10.4049/jimmunol.178.7.4498. J Immunol. 2007. PMID: 17372008 Free PMC article.
Differentiation of Ag-specific T cells into IFN-gamma producers is essential for protective immunity to intracellular pathogens. ...Two such inflammatory cytokines are IL-12 and type I IFN (IFN-I); both can play a role in priming naive T cells to produce IFN-gamma i …
Differentiation of Ag-specific T cells into IFN-gamma producers is essential for protective immunity to intracellular pathogens. ...T …
Functional and transcriptional heterogeneity within the massively expanding HLADR+CD38+ CD8 T cell population in acute febrile dengue patients.
Singh P, Bajpai P, Maheshwari D, Chawla YM, Saini K, Reddy ES, Gottimukkala K, Nayak K, Gunisetty S, Aggarwal C, Jain S, Verma C, Singla P, Soneja M, Wig N, Murali-Krishna K, Chandele A. Singh P, et al. J Virol. 2023 Nov 30;97(11):e0074623. doi: 10.1128/jvi.00746-23. Epub 2023 Oct 19. J Virol. 2023. PMID: 37855600 Free PMC article.
CD8 T cells play a crucial role in protecting against intracellular pathogens such as viruses by eliminating infected cells and releasing anti-viral cytokines such as interferon gamma (IFNgamma). Consequently, there is significant interest in comprehensively characterizing …
CD8 T cells play a crucial role in protecting against intracellular pathogens such as viruses by eliminating infected cells and releasing an …
Structural insights for neutralization of Omicron variants BA.1, BA.2, BA.4, and BA.5 by a broadly neutralizing SARS-CoV-2 antibody.
Kumar S, Patel A, Lai L, Chakravarthy C, Valanparambil R, Reddy ES, Gottimukkala K, Davis-Gardner ME, Edara VV, Linderman S, Nayak K, Dixit K, Sharma P, Bajpai P, Singh V, Frank F, Cheedarla N, Verkerke HP, Neish AS, Roback JD, Mantus G, Goel PK, Rahi M, Davis CW, Wrammert J, Godbole S, Henry AR, Douek DC, Suthar MS, Ahmed R, Ortlund E, Sharma A, Murali-Krishna K, Chandele A. Kumar S, et al. Sci Adv. 2022 Oct 7;8(40):eadd2032. doi: 10.1126/sciadv.add2032. Epub 2022 Oct 5. Sci Adv. 2022. PMID: 36197988 Free PMC article.
In this study, by characterizing several human monoclonal antibodies (mAbs) isolated from single B cells of the COVID-19-recovered individuals in India who experienced ancestral Wuhan strain (WA.1) of SARS-CoV-2 during early stages of the pandemic, we found a receptor binding dom …
In this study, by characterizing several human monoclonal antibodies (mAbs) isolated from single B cells of the COVID-19-recovered individua …
Characterization of Human CD8 T Cell Responses in Dengue Virus-Infected Patients from India.
Chandele A, Sewatanon J, Gunisetty S, Singla M, Onlamoon N, Akondy RS, Kissick HT, Nayak K, Reddy ES, Kalam H, Kumar D, Verma A, Panda H, Wang S, Angkasekwinai N, Pattanapanyasat K, Chokephaibulkit K, Medigeshi GR, Lodha R, Kabra S, Ahmed R, Murali-Krishna K. Chandele A, et al. J Virol. 2016 Nov 28;90(24):11259-11278. doi: 10.1128/JVI.01424-16. Print 2016 Dec 15. J Virol. 2016. PMID: 27707928 Free PMC article.
Interestingly, only a small fraction of these activated effector CD8 T cells produced gamma interferon (IFN-gamma) when stimulated with dengue virus peptide pools. ...Consistent with this, the majority of these CD8 T cells remained IFN-gamma unresponsive even …
Interestingly, only a small fraction of these activated effector CD8 T cells produced gamma interferon (IFN-gamma) when stimul …
CpG oligonucleotide-mediated co-stimulation of mouse invariant natural killer T cells negatively regulates their activation status.
Kulkarni RR, Villanueva AI, Read LR, Brisbin JT, Bhaumik SK, LaMarre J, Murali-Krishna K, Sharif S. Kulkarni RR, et al. Cell Tissue Res. 2017 Sep;369(3):541-554. doi: 10.1007/s00441-017-2631-y. Epub 2017 May 27. Cell Tissue Res. 2017. PMID: 28550425
We show that CpG treatment of iNKT cells in the presence of higher concentrations of TCR agonists (alpha-GalCer or anti-CD3 mAb) results in the up-regulation of TLR9 in iNKT cells with a concurrent reduction in their cellular activation, as assessed by their production of IL-2, I …
We show that CpG treatment of iNKT cells in the presence of higher concentrations of TCR agonists (alpha-GalCer or anti-CD3 mAb) results in …
Structural and functional characterization of a novel immunomodulatory glycoprotein isolated from ajowan (Trachyspermum ammi L.).
Shruthi RR, Venkatesh YP, Muralikrishna G. Shruthi RR, et al. Glycoconj J. 2017 Aug;34(4):499-514. doi: 10.1007/s10719-017-9771-x. Epub 2017 May 10. Glycoconj J. 2017. PMID: 28493026
RAW 264.7 cells produced pro-inflammatory cytokines (IL-12, TNF-alpha and IFN-gamma) at 1 mug/mL Agp (p < 0.01). Deproteinized Agp (dpAgp) failed to elicit activation of murine immune cells, whereas deglycosylated Agp (20 kDa; dgAgp) showed compromised efficiency. ...

RAW 264.7 cells produced pro-inflammatory cytokines (IL-12, TNF-alpha and IFN-gamma) at 1 mug/mL Agp (p < 0.01). Deproteinized Agp

…
Identification of novel Mycobacterium tuberculosis CD4 T-cell antigens via high throughput proteome screening.
Nayak K, Jing L, Russell RM, Davies DH, Hermanson G, Molina DM, Liang X, Sherman DR, Kwok WW, Yang J, Kenneth J, Ahamed SF, Chandele A, Murali-Krishna K, Koelle DM. Nayak K, et al. Tuberculosis (Edinb). 2015 May;95(3):275-87. doi: 10.1016/j.tube.2015.03.001. Epub 2015 Mar 27. Tuberculosis (Edinb). 2015. PMID: 25857935 Free PMC article.
Elicitation of CD4 IFN-gamma T cell responses to Mycobacterium tuberculosis (MTB) is a rational vaccine strategy to prevent clinical tuberculosis. ...
Elicitation of CD4 IFN-gamma T cell responses to Mycobacterium tuberculosis (MTB) is a rational vaccine strategy to prevent clinical …
22 results