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The changing epigenetic landscape of Mesenchymal Stem/Stromal Cells during aging.
Cakouros D, Gronthos S. Cakouros D, et al. Bone. 2020 Aug;137:115440. doi: 10.1016/j.bone.2020.115440. Epub 2020 May 20. Bone. 2020. PMID: 32445894 Review.
This review addresses recent findings examining DNA methylation, histone modifications and miRNA changes in aging MSC populations. Moreover, we explore how epigenetic factors alter cellular pathways and associated biological networks, contributing to the MSC aging phenotyp …
This review addresses recent findings examining DNA methylation, histone modifications and miRNA changes in aging MSC populations. Mo …
microRNAs Expression as Novel Genetic Biomarker for Early Prediction and Continuous Monitoring in Pulmonary Cancer.
Nitu R, Rogobete AF, Gundogdu F, Tanasescu S, Boruga O, Sas A, Popovici SE, Hutanu D, Pilut C, Sarau CA, Candea AC, Stan AT, Moise LM. Nitu R, et al. Biochem Genet. 2017 Aug;55(4):281-290. doi: 10.1007/s10528-016-9789-y. Epub 2017 Jan 9. Biochem Genet. 2017. PMID: 28070693 Review.
An ideal biomarker candidate is represented by the analysis of microRNAs expression. In this paper, we want to summarize microRNAs expressions in lung cancer. ...To evaluate and monitor lung cancer, the expression of microRNAs may be used successfully due to …
An ideal biomarker candidate is represented by the analysis of microRNAs expression. In this paper, we want to summarize microRNAs …
Identification of a circulating miRNA signature in extracellular vesicles collected from amyotrophic lateral sclerosis patients.
Saucier D, Wajnberg G, Roy J, Beauregard AP, Chacko S, Crapoulet N, Fournier S, Ghosh A, Lewis SM, Marrero A, O'Connell C, Ouellette RJ, Morin PJ. Saucier D, et al. Brain Res. 2019 Apr 1;1708:100-108. doi: 10.1016/j.brainres.2018.12.016. Epub 2018 Dec 12. Brain Res. 2019. PMID: 30552897
Next-generation sequencing was used to identify differentially expressed miRNAs recovered from EVs of PALS and healthy controls. High-throughput sequencing data for select miRNA targets was subsequently validated by droplet digital PCR (ddPCR). This approach reveale …
Next-generation sequencing was used to identify differentially expressed miRNAs recovered from EVs of PALS and healthy controls. High …
MIRELLA: a mathematical model explains the effect of microRNA-mediated synthetic genes regulation on intracellular resource allocation.
Cella F, Perrino G, Tedeschi F, Viero G, Bosia C, Stan GB, Siciliano V. Cella F, et al. Nucleic Acids Res. 2023 Apr 24;51(7):3452-3464. doi: 10.1093/nar/gkad151. Nucleic Acids Res. 2023. PMID: 36912077 Free PMC article.
Despite the extensive use of miRNA in synthetic circuits regulation, this indirect effect was never reported before. Here we developed a synthetic genetic system that embeds miRNA regulation, and a mathematical model, MIRELLA, to unravel the miRNA (MI) RolE o …
Despite the extensive use of miRNA in synthetic circuits regulation, this indirect effect was never reported before. Here we develope …
Characterization and mitigation of gene expression burden in mammalian cells.
Frei T, Cella F, Tedeschi F, Gutiérrez J, Stan GB, Khammash M, Siciliano V. Frei T, et al. Nat Commun. 2020 Sep 15;11(1):4641. doi: 10.1038/s41467-020-18392-x. Nat Commun. 2020. PMID: 32934213 Free PMC article.
Guided by a resource-aware mathematical model, we identify and engineer natural and synthetic miRNA-based incoherent feedforward loop (iFFL) circuits that mitigate gene expression burden. The implementation of these circuits features the use of endogenous miRNAs as …
Guided by a resource-aware mathematical model, we identify and engineer natural and synthetic miRNA-based incoherent feedforward loop …
Follicular adenoma and carcinoma of the thyroid gland.
McHenry CR, Phitayakorn R. McHenry CR, et al. Oncologist. 2011;16(5):585-93. doi: 10.1634/theoncologist.2010-0405. Epub 2011 Apr 11. Oncologist. 2011. PMID: 21482585 Free PMC article.
Identification of a dicer homologue gene (DCL2) in Nicotiana tabacum.
Udriste AA, Stan V, Radu GL, Tabler M, Cucu N. Udriste AA, et al. Plant Biol (Stuttg). 2012 Nov;14(6):980-6. doi: 10.1111/j.1438-8677.2012.00586.x. Epub 2012 Jul 19. Plant Biol (Stuttg). 2012. PMID: 22812643
Eukaryotes possess a mechanism that generates small interfering RNA (siRNA) and microRNA (miRNA) and use these to regulate gene expression at the transcriptional or post-transcriptional level. ...
Eukaryotes possess a mechanism that generates small interfering RNA (siRNA) and microRNA (miRNA) and use these to regulate gene expre …
Epithelial microRNA-9a regulates dendrite growth through Fmi-Gq signaling in Drosophila sensory neurons.
Wang Y, Wang H, Li X, Li Y. Wang Y, et al. Dev Neurobiol. 2016 Feb;76(2):225-37. doi: 10.1002/dneu.22309. Epub 2015 Jun 8. Dev Neurobiol. 2016. PMID: 26016469
Our findings provide novel insights into the complex regulatory mechanisms of microRNAs in dendrite development, and further reveal the interplay between the different components of Fmi, functioning in cadherin adhesion and GPCR signalling....
Our findings provide novel insights into the complex regulatory mechanisms of microRNAs in dendrite development, and further reveal t …