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Involvement of the Na(+), K(+)-ATPase alpha1 Isoform and Endogenous Cardiac Steroids in Depression- and Manic-like Behaviors.
Horesh N, Pelov I, Pogodin I, Zannadeh H, Rosen H, Mikhrina AL, Dvela-Levitt M, Sampath VP, Lichtstein D. Horesh N, et al. Int J Mol Sci. 2024 Jan 29;25(3):1644. doi: 10.3390/ijms25031644. Int J Mol Sci. 2024. PMID: 38338921 Free PMC article.
Bipolar disorder (BD) is a severe and common chronic mental illness characterized by recurrent mood swings between depression and mania. The biological basis of the disease is poorly understood, and its treatment is unsatisfactory. ...These results suggest that the Na(+), …
Bipolar disorder (BD) is a severe and common chronic mental illness characterized by recurrent mood swings between depression and mania …
Sleep study in Disruptive Mood Dysregulation Disorder and Bipolar children.
Estrada-Prat X, Álvarez-Guerrico I, Bleda-Hernández MJ, Camprodon-Rosanas E, Batlle-Vila S, Pujals-Altes E, Nascimento-Osorio MT, Martín-López LM, Álvarez-Martínez E, Pérez-Solá V, Romero-Cela S. Estrada-Prat X, et al. Actas Esp Psiquiatr. 2017 Jan;45(1):12-20. Epub 2017 Jan 1. Actas Esp Psiquiatr. 2017. PMID: 28186315 Free article.
INTRODUCTION: Decreased need for sleep has been proposed as a core symptom of mania and it has been associated with the pathogenesis of Bipolar Disorder. ...
INTRODUCTION: Decreased need for sleep has been proposed as a core symptom of mania and it has been associated with the pathogenesis …
Lithium and Tamoxifen Modulate Behavior and Protein Kinase C Activity in the Animal Model of Mania Induced by Ouabain.
Valvassori SS, Dal-Pont GC, Resende WR, Varela RB, Peterle BR, Gava FF, Mina FG, Cararo JH, Carvalho AF, Quevedo J. Valvassori SS, et al. Int J Neuropsychopharmacol. 2017 Nov 1;20(11):877-885. doi: 10.1093/ijnp/pyx049. Int J Neuropsychopharmacol. 2017. PMID: 29020306 Free PMC article.
BACKGROUND: The intracerebroventricular injection of ouabain, a specific inhibitor of the Na+/K+-adenosine-triphosphatase (Na+/K+-ATPase) enzyme, induces hyperactivity in rats in a putative animal model of mania. Several evidences have suggested that the protein kinase C s …
BACKGROUND: The intracerebroventricular injection of ouabain, a specific inhibitor of the Na+/K+-adenosine-triphosphatase (Na+/K+-ATPase) en …
Lithium and valproate modulate antioxidant enzymes and prevent ouabain-induced oxidative damage in an animal model of mania.
Jornada LK, Valvassori SS, Steckert AV, Moretti M, Mina F, Ferreira CL, Arent CO, Dal-Pizzol F, Quevedo J. Jornada LK, et al. J Psychiatr Res. 2011 Feb;45(2):162-8. doi: 10.1016/j.jpsychires.2010.05.011. Epub 2010 Jun 2. J Psychiatr Res. 2011. PMID: 20627318
In this study, we assessed the oxidative stress parameters in rats submitted to an animal model of mania induced by ouabain (OUA), which included the use of lithium (Li) and valproate (VPA). ...Our results support the notion that Li and VPA exert antioxidant-like propertie …
In this study, we assessed the oxidative stress parameters in rats submitted to an animal model of mania induced by ouabain (OUA), wh …
Effects of sodium butyrate on oxidative stress and behavioral changes induced by administration of D-AMPH.
Steckert AV, Valvassori SS, Varela RB, Mina F, Resende WR, Bavaresco DV, Ornell F, Dal-Pizzol F, Quevedo J. Steckert AV, et al. Neurochem Int. 2013 Mar;62(4):425-32. doi: 10.1016/j.neuint.2013.02.001. Epub 2013 Feb 11. Neurochem Int. 2013. PMID: 23411414
In this study, we investigated the effects of sodium butyrate (SB, a histone deacetilase inhibitor) on oxidative stress in rats submitted to an animal model of mania induced by d-amphetamine (d-AMPH). Wistar rats were first given d-AMPH or saline (Sal) for 14 days, and the …
In this study, we investigated the effects of sodium butyrate (SB, a histone deacetilase inhibitor) on oxidative stress in rats submitted to …
Protein kinase C and oxidative stress in an animal model of mania.
Steckert AV, Valvassori SS, Mina F, Lopes-Borges J, Varela RB, Kapczinski F, Dal-Pizzol F, Quevedo J. Steckert AV, et al. Curr Neurovasc Res. 2012 Feb;9(1):47-57. doi: 10.2174/156720212799297056. Curr Neurovasc Res. 2012. PMID: 22272765
The present study aims to investigate the effects of protein kinase C using the inhibitor Tamoxifen (TMX) on oxidative stress in a rat animal model of mania induced by d-amphetamine (d-AMPH). In the reversal model, d-AMPH or saline (Sal) were administered to rats for 14 da …
The present study aims to investigate the effects of protein kinase C using the inhibitor Tamoxifen (TMX) on oxidative stress in a rat anima …
Analysis of differential clinical profiles of different antipsychotic molecules in the first psychotic episode: a retrospective study.
Spanarello S, Beoni AM, Mina G, Amantini K, Colotto A. Spanarello S, et al. Encephale. 2005 Nov-Dec;31(6 Pt 1):692-7. doi: 10.1016/s0013-7006(05)82427-3. Encephale. 2005. PMID: 16462688
Our aim has been the therapeutic profile evaluation of atypical anti-psychotic molecules vs. typical ones, using "Liege's star" parameters (anti- manic, anti-autistic, anti-delusional, extra-pyramidal, ataraxic-sedative and adrenolitic). ...
Our aim has been the therapeutic profile evaluation of atypical anti-psychotic molecules vs. typical ones, using "Liege's star" parameters ( …