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Chikungunya and O'nyong-nyong Viruses in Uganda: Implications for Diagnostics.
Clements TL, Rossi CA, Irish AK, Kibuuka H, Eller LA, Robb ML, Kataaha P, Michael NL, Hensley LE, Schoepp RJ. Clements TL, et al. Open Forum Infect Dis. 2019 Jan 3;6(3):ofz001. doi: 10.1093/ofid/ofz001. eCollection 2019 Mar. Open Forum Infect Dis. 2019. PMID: 31660384 Free PMC article.
Further investigation of CHIKV-positive sera demonstrated that the majority of antibody responses may likely be the result of exposure to the closely related alphavirus o'nyong-nyong virus (ONNV). CONCLUSIONS: As the use of highly specific and sensitive polymerase c …
Further investigation of CHIKV-positive sera demonstrated that the majority of antibody responses may likely be the result of exposure to th …
Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers.
Raja SM, Clubb RJ, Ortega-Cava C, Williams SH, Bailey TA, Duan L, Zhao X, Reddi AL, Nyong AM, Natarajan A, Band V, Band H. Raja SM, et al. Cancer Biol Ther. 2011 Jan 15;11(2):263-76. doi: 10.4161/cbt.11.2.13959. Epub 2011 Jan 15. Cancer Biol Ther. 2011. PMID: 21088503 Free PMC article.
Mechanistically, Celastrol not only induced the expected ubiquitinylation and degradation of ErbB2 and other HSP90 client proteins, but it also increased the levels of reactive oxygen species (ROS). Our studies show that the Michael Acceptor functionality in Celastrol is i …
Mechanistically, Celastrol not only induced the expected ubiquitinylation and degradation of ErbB2 and other HSP90 client proteins, but it a …