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PlGF blockade does not inhibit angiogenesis during primary tumor growth.
Bais C, Wu X, Yao J, Yang S, Crawford Y, McCutcheon K, Tan C, Kolumam G, Vernes JM, Eastham-Anderson J, Haughney P, Kowanetz M, Hagenbeek T, Kasman I, Reslan HB, Ross J, Van Bruggen N, Carano RA, Meng YJ, Hongo JA, Stephan JP, Shibuya M, Ferrara N. Bais C, et al. Cell. 2010 Apr 2;141(1):166-77. doi: 10.1016/j.cell.2010.01.033. Cell. 2010. PMID: 20371352 Free article.
Multimodal microvascular imaging reveals that selective inhibition of class I PI3K is sufficient to induce an antivascular response.
Sampath D, Oeh J, Wyatt SK, Cao TC, Koeppen H, Eastham-Anderson J, Robillard L, Ho CC, Ross J, Zhuang G, Reslan HB, Vitorino P, Barck KH, Ungersma SE, Vernes JM, Caunt M, Van Bruggen N, Ye W, Vijapurkar U, Meng YJ, Ferrara N, Friedman LS, Carano RA. Sampath D, et al. Neoplasia. 2013 Jul;15(7):694-711. doi: 10.1593/neo.13470. Neoplasia. 2013. PMID: 23814482 Free PMC article.