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Adaptations of protein structure and function to temperature: there is more than one way to 'skin a cat'.
Fields PA, Dong Y, Meng X, Somero GN. Fields PA, et al. J Exp Biol. 2015 Jun;218(Pt 12):1801-11. doi: 10.1242/jeb.114298. J Exp Biol. 2015. PMID: 26085658 Review.
A series of studies using two structurally and catalytically related enzymes, A4-lactate dehydrogenase (A4-LDH) and cytosolic malate dehydrogenase (cMDH) have been especially valuable in determining the functional attributes of enzymes most sensitive to temperature, and id …
A series of studies using two structurally and catalytically related enzymes, A4-lactate dehydrogenase (A4-LDH) and cytosolic malate …
Length of course-based undergraduate research experiences (CURE) impacts student learning and attitudinal outcomes: A study of the Malate dehydrogenase CUREs Community (MCC).
DeChenne-Peters SE, Rakus JF, Parente AD, Mans TL, Eddy R, Galport N, Koletar C, Provost JJ, Bell JE, Bell JK. DeChenne-Peters SE, et al. PLoS One. 2023 Mar 9;18(3):e0282170. doi: 10.1371/journal.pone.0282170. eCollection 2023. PLoS One. 2023. PMID: 36893201 Free PMC article.
Course-based undergraduate research experiences (CUREs) are laboratory courses that integrate broadly relevant problems, discovery, use of the scientific process, collaboration, and iteration to provide more students with research experiences than is possible in individually ment …
Course-based undergraduate research experiences (CUREs) are laboratory courses that integrate broadly relevant problems, discovery, use of t …
Parahydrogen-Polarized Fumarate for Preclinical in Vivo Metabolic Magnetic Resonance Imaging.
Gierse M, Nagel L, Keim M, Lucas S, Speidel T, Lobmeyer T, Winter G, Josten F, Karaali S, Fellermann M, Scheuer J, Müller C, van Heijster F, Skinner J, Löffler J, Parker A, Handwerker J, Marshall A, Salhov A, El-Kassem B, Vassiliou C, Blanchard JW, Picazo-Frutos R, Eills J, Barth H, Jelezko F, Rasche V, Schilling F, Schwartz I, Knecht S. Gierse M, et al. J Am Chem Soc. 2023 Mar 15;145(10):5960-5969. doi: 10.1021/jacs.2c13830. Epub 2023 Mar 1. J Am Chem Soc. 2023. PMID: 36857421
The in vivo usage of the hyperpolarized fumarate as a perfusion agent in healthy mice and the metabolic conversion of fumarate to malate in tumor-bearing mice developing regions with necrotic cell death is demonstrated. ...
The in vivo usage of the hyperpolarized fumarate as a perfusion agent in healthy mice and the metabolic conversion of fumarate to malate …
Seasonal variation in Hibiscus sabdariffa (Roselle) calyx phytochemical profile, soluble solids and α-glucosidase inhibition.
Ifie I, Ifie BE, Ibitoye DO, Marshall LJ, Williamson G. Ifie I, et al. Food Chem. 2018 Sep 30;261:164-168. doi: 10.1016/j.foodchem.2018.04.052. Epub 2018 Apr 16. Food Chem. 2018. PMID: 29739578
There was a significant increase (1.4-fold; p 0.05) in total anthocyanin content in the dry compared to wet planting seasons, and maltase inhibition from the dry season was slightly more potent (1.15-fold, p 0.05). Fructose (1.8-fold), glucose (1.8-fold) and malic acid …
There was a significant increase (1.4-fold; p 0.05) in total anthocyanin content in the dry compared to wet planting seasons, and maltase in …
Temperature sensitivities of cytosolic malate dehydrogenases from native and invasive species of marine mussels (genus Mytilus): sequence-function linkages and correlations with biogeographic distribution.
Fields PA, Rudomin EL, Somero GN. Fields PA, et al. J Exp Biol. 2006 Feb;209(Pt 4):656-67. doi: 10.1242/jeb.02036. J Exp Biol. 2006. PMID: 16449560
We have examined the structure and function of the enzyme cytosolic malate dehydrogenase (cMDH) from these species, as well as from the more distantly related ribbed mussel, Mytilus californianus, to characterize the effects of temperature on kinetic properties thought to …
We have examined the structure and function of the enzyme cytosolic malate dehydrogenase (cMDH) from these species, as well as from t …
Dietary and Animal Strategies to Reduce the Environmental Impact of Pastoral Dairy Systems Result in Altered Nutraceutical Profiles in Milk.
Marshall CJ, Garrett K, Van Vliet S, Beck MR, Gregorini P. Marshall CJ, et al. Animals (Basel). 2022 Oct 31;12(21):2994. doi: 10.3390/ani12212994. Animals (Basel). 2022. PMID: 36359120 Free PMC article.
High MUNBV cows had a greater abundance of methionine sulfoxide, malate, 1,5-anhydroglucitol (1,5-AG), glycerate, arabitol/xylitol, 3-hydroxy-3-methylglutarate, 5-hydroxylysine and cystine (p < 0.05). ...
High MUNBV cows had a greater abundance of methionine sulfoxide, malate, 1,5-anhydroglucitol (1,5-AG), glycerate, arabitol/xylitol, 3 …
Regulation of aminotransferase-glutamate dehydrogenase interactions by carbamyl phosphate synthase-I, Mg2+ plus leucine versus citrate and malate.
Fahien LA, Kmiotek EH, Woldegiorgis G, Evenson M, Shrago E, Marshall M. Fahien LA, et al. J Biol Chem. 1985 May 25;260(10):6069-79. J Biol Chem. 1985. PMID: 3997814 Free article.
Citrate, malate, and high levels of ATP dissociate the mitochondrial aspartate aminotransferase-glutamate dehydrogenase complex and have an inhibitory effect on the latter enzyme. ...Alternatively, Krebs cycle intermediates, such as citrate and malate, have opposing …
Citrate, malate, and high levels of ATP dissociate the mitochondrial aspartate aminotransferase-glutamate dehydrogenase complex and h …
Impact of 1% malic acid spray on the oral health-related quality of life of patients with xerostomia.
Niklander S, Fuentes F, Sanchez D, Araya V, Chiappini G, Martinez R, Marshall M. Niklander S, et al. J Oral Sci. 2018;60(2):278-284. doi: 10.2334/josnusd.17-0164. J Oral Sci. 2018. PMID: 29925712 Free article. Clinical Trial.
Dry mouth sensation, also known as xerostomia, is a common clinical problem with an increasing prevalence. Although recent studies have reported promissory results of malic acid, none have evaluated the impact of malic acid on the oral health-related q …
Dry mouth sensation, also known as xerostomia, is a common clinical problem with an increasing prevalence. Although recent studies have repo …
Nutrient enrichment induces a shift in dissolved organic carbon (DOC) metabolism in oligotrophic freshwater sediments.
Brailsford FL, Glanville HC, Golyshin PN, Marshall MR, Lloyd CE, Johnes PJ, Jones DL. Brailsford FL, et al. Sci Total Environ. 2019 Nov 10;690:1131-1139. doi: 10.1016/j.scitotenv.2019.07.054. Epub 2019 Jul 4. Sci Total Environ. 2019. PMID: 31470476 Free article.
This is directly supported by the metabolomic profile data which identified significant differences in 22 known metabolites (34% of the total) and 30 unknown metabolites (16% of the total) upon the addition of either N or P. (14)C-glucose addition increased the production of orga …
This is directly supported by the metabolomic profile data which identified significant differences in 22 known metabolites (34% of the tota …
24 results