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Abnormal patterns of DNA methylation in human neoplasia: potential consequences for tumor progression.
Baylin SB, Makos M, Wu JJ, Yen RW, de Bustros A, Vertino P, Nelkin BD. Baylin SB, et al. Cancer Cells. 1991 Oct;3(10):383-90. Cancer Cells. 1991. PMID: 1777359 Review.
We argue here that the altered methylation patterns observed during tumor progression, especially regional hypermethylation, may mark--or even help to establish--abnormalities of chromatin organization. ...
We argue here that the altered methylation patterns observed during tumor progression, especially regional hypermethylation, may mark …
The short arm of chromosome 11 is a "hot spot" for hypermethylation in human neoplasia.
de Bustros A, Nelkin BD, Silverman A, Ehrlich G, Poiesz B, Baylin SB. de Bustros A, et al. Proc Natl Acad Sci U S A. 1988 Aug;85(15):5693-7. doi: 10.1073/pnas.85.15.5693. Proc Natl Acad Sci U S A. 1988. PMID: 2840671 Free PMC article.
The increased regional DNA methylation demonstrated may then participate in or mark chromosomal changes associated with gene inactivation events that are central to the genesis and/or progression of human cancers....
The increased regional DNA methylation demonstrated may then participate in or mark chromosomal changes associated with gene inactiva …