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Geometry of metal-ligand interactions in proteins.
Harding MM. Harding MM. Acta Crystallogr D Biol Crystallogr. 2001 Mar;57(Pt 3):401-11. doi: 10.1107/s0907444900019168. Acta Crystallogr D Biol Crystallogr. 2001. PMID: 11223517
The geometry of metal-ligand interactions in proteins is examined and compared with information for small-molecule complexes from the Cambridge Structural Database (CSD). ...It assesses the agreement between geometry found in all metalloprotein structures in the Protein Da …
The geometry of metal-ligand interactions in proteins is examined and compared with information for small-molecule complexes from the …
The geometry of metal-ligand interactions relevant to proteins.
Harding MM. Harding MM. Acta Crystallogr D Biol Crystallogr. 1999 Aug;55(Pt 8):1432-43. doi: 10.1107/s0907444999007374. Acta Crystallogr D Biol Crystallogr. 1999. PMID: 10417412
The structures selected have a crystallographic R factor ligands which are analogues of the amino-acid side chains commonly found in proteins; they include carboxylate groups, alcohols, phenolates, thiolate …
The structures selected have a crystallographic R factor ligands w …
Interactions between NRP1 and VEGFR2 molecules in the plasma membrane.
King C, Wirth D, Workman S, Hristova K. King C, et al. Biochim Biophys Acta Biomembr. 2018 Oct;1860(10):2118-2125. doi: 10.1016/j.bbamem.2018.03.023. Epub 2018 Apr 7. Biochim Biophys Acta Biomembr. 2018. PMID: 29630862 Free PMC article.
Experiments are performed both in the absence and presence of the soluble ligand vascular endothelial growth factor A (VEGFA), which binds to both VEGFR2 and NRP1. ...This article is part of a Special Issue entitled: Emergence of Complex Behavior in Biomembranes edited by …
Experiments are performed both in the absence and presence of the soluble ligand vascular endothelial growth factor A (VEGFA), which …
Metal-ligand geometry relevant to proteins and in proteins: sodium and potassium.
Harding MM. Harding MM. Acta Crystallogr D Biol Crystallogr. 2002 May;58(Pt 5):872-4. doi: 10.1107/s0907444902003712. Epub 2002 Apr 26. Acta Crystallogr D Biol Crystallogr. 2002. PMID: 11976508
D57, 401-411, and references therein] the geometry of metal-ligand interactions was examined for six metals (Ca, Mg, Mn, Fe, Cu, Zn) using the Protein Data Bank and compared with information from accurately determined structures of relevant small-molecule crystals in the C …
D57, 401-411, and references therein] the geometry of metal-ligand interactions was examined for six metals (Ca, Mg, Mn, Fe, Cu, Zn) …
The geometry of metal-ligand interactions relevant to proteins. II. Angles at the metal atom, additional weak metal-donor interactions.
Harding MM. Harding MM. Acta Crystallogr D Biol Crystallogr. 2000 Jul;56(Pt 7):857-67. doi: 10.1107/s0907444900005849. Acta Crystallogr D Biol Crystallogr. 2000. PMID: 10930832
For simple non-chelated complexes of Mn, Fe and Zn, distortions of up to 5 degrees in octahedral complexes and 10 degrees in tetrahedral complexes are found to be normal and seem likely to be a consequence of packing effects, ligand bulk or intramolecular effects. Substant …
For simple non-chelated complexes of Mn, Fe and Zn, distortions of up to 5 degrees in octahedral complexes and 10 degrees in tetrahedral com …
Generation of Human Breg-Like Phenotype with Regulatory Function In Vitro with Bacteria-Derived Oligodeoxynucleotides.
Gallego-Valle J, Pérez-Fernández VA, Correa-Rocha R, Pion M. Gallego-Valle J, et al. Int J Mol Sci. 2018 Jun 12;19(6):1737. doi: 10.3390/ijms19061737. Int J Mol Sci. 2018. PMID: 29895745 Free PMC article.
This project aims to test the capacity of several cytokines (Interleukin 1-beta (IL-1beta), Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF), and Cluster of differentiation 40 ligand (CD40L)) and bacteria-derived oligodeoxynucleotides (CpG-ODN), alone or in combin …
This project aims to test the capacity of several cytokines (Interleukin 1-beta (IL-1beta), Granulocyte Macrophage Colony-Stimulating Factor …
Herpes simplex virus protein kinase US3 activates and functionally overlaps protein kinase A to block apoptosis.
Benetti L, Roizman B. Benetti L, et al. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9411-6. doi: 10.1073/pnas.0403160101. Epub 2004 Jun 10. Proc Natl Acad Sci U S A. 2004. PMID: 15192152 Free PMC article.
Herpes simplex virus 1 encodes at least four genes whose functions include blocking apoptosis induced by exogenous agents (e.g., sorbitol, Fas ligand, and BAD protein) or replication-incompetent mutants (e.g., the d120 mutant lacking both copies of the alpha 4 gene). ...
Herpes simplex virus 1 encodes at least four genes whose functions include blocking apoptosis induced by exogenous agents (e.g., sorbitol, F …
Characterization of a recombinant herpes simplex virus 1 designed to enter cells via the IL13Ralpha2 receptor of malignant glioma cells.
Zhou G, Roizman B. Zhou G, et al. J Virol. 2005 May;79(9):5272-7. doi: 10.1128/JVI.79.9.5272-5277.2005. J Virol. 2005. PMID: 15827141 Free PMC article.
(i) Expression of IL13Ralpha2 was rapidly lost from the surface of transduced cells grown in culture. The loss appeared to be related to ligands present in fetal bovine serum in the medium. None of the malignant glioma cell lines cultivated in vitro and tested to date exhi …
(i) Expression of IL13Ralpha2 was rapidly lost from the surface of transduced cells grown in culture. The loss appeared to be related to …
Separation of receptor-binding and profusogenic domains of glycoprotein D of herpes simplex virus 1 into distinct interacting proteins.
Zhou G, Roizman B. Zhou G, et al. Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4142-6. doi: 10.1073/pnas.0611565104. Epub 2007 Feb 27. Proc Natl Acad Sci U S A. 2007. PMID: 17360490 Free PMC article.
These results indicate that codons 61-218 of gD do not encode executable functions required for viral entry into cells and suggest that the receptor-binding ligand must interact with but need not alter the structure of the residual portion of gD to effect virus entry. ...
These results indicate that codons 61-218 of gD do not encode executable functions required for viral entry into cells and suggest that the …
Herpes simplex virus 1 recombinant virions exhibiting the amino terminal fragment of urokinase-type plasminogen activator can enter cells via the cognate receptor.
Kamiyama H, Zhou G, Roizman B. Kamiyama H, et al. Gene Ther. 2006 Apr;13(7):621-9. doi: 10.1038/sj.gt.3302685. Gene Ther. 2006. PMID: 16292350
Earlier this laboratory constructed a herpes simplex virus 1 recombinant (R5111) that carries a IL13 ligand inserted into glycoprotein D and can enter cells via the IL13Ralpha2 receptor commonly expressed on the surface of malignant glioma cells. ...These viruses were cons …
Earlier this laboratory constructed a herpes simplex virus 1 recombinant (R5111) that carries a IL13 ligand inserted into glycoprotei …
11 results