A Polynesian-specific copy number variant encompassing the MICA gene associates with gout.
Wang K, Cadzow M, Bixley M, Leask MP, Merriman ME, Yang Q, Li Z, Takei R, Phipps-Green A, Major TJ, Topless R, Dalbeth N, King F, Murphy R, Stamp LK, de Zoysa J, Wang Z, Shi Y, Merriman TR.
Wang K, et al.
Hum Mol Genet. 2022 Oct 28;31(21):3757-3768. doi: 10.1093/hmg/ddac094.
Hum Mol Genet. 2022.
PMID: 35451026
Free PMC article.
Gout is of particularly high prevalence in the Maori and Pacific (Polynesian) populations of Aotearoa New Zealand (NZ). ...In summary, we provide evidence for the association of CNVR1 containing MICA with gout in Polynesian people, implicating class I MHC-mediated a …
Gout is of particularly high prevalence in the Maori and Pacific (Polynesian) populations of Aotearoa New Zealand (NZ). ...In summary …