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Page 1
Axelrod Symposium 2019: Phosphoproteomic Analysis of G-Protein-Coupled Pathways.
Schleicher K, Zaccolo M. Schleicher K, et al. Mol Pharmacol. 2021 May;99(5):383-391. doi: 10.1124/mol.119.118869. Epub 2020 Feb 28. Mol Pharmacol. 2021. PMID: 32111700 Review.
In this minireview we summarize advanced imaging and proteomics techniques that have been successfully used to probe compartmentalized cAMP signaling in eukaryotic cells. Subcellularly targeted fluorescence resonance energy transfer sensors can precisely locate and measure …
In this minireview we summarize advanced imaging and proteomics techniques that have been successfully used to probe compartmentalize …
Gingival recession after scaling and root planing with or without systemic metronidazole and amoxicillin: a re-review.
Kaufmann ME, Wiedemeier DB, Zellweger U, Solderer A, Attin T, Schmidlin PR. Kaufmann ME, et al. Clin Oral Investig. 2020 Mar;24(3):1091-1100. doi: 10.1007/s00784-020-03198-4. Epub 2020 Jan 15. Clin Oral Investig. 2020. PMID: 31938962 Free article. Review.
MATERIALS AND METHODS: This study re-analyzed publications that reported clinical attachment levels (CAL) and probing pocket depths (PD) up to January 2019, including the pivotal review by Zandbergen and co-workers (2013). ...
MATERIALS AND METHODS: This study re-analyzed publications that reported clinical attachment levels (CAL) and probing pocket depths ( …
The right tools for the job: the central role for next generation chemical probes and chemistry-based target deconvolution methods in phenotypic drug discovery.
Jörg M, Madden KS. Jörg M, et al. RSC Med Chem. 2021 Mar 24;12(5):646-665. doi: 10.1039/d1md00022e. RSC Med Chem. 2021. PMID: 34124668 Free PMC article. Review.
This remains a key stumbling block for the field which needs to be overcome in order to fully realise the potential of phenotypic drug discovery. Excellent quality chemical probes and chemistry-based target deconvolution techniques will be a crucial part of this process. I …
This remains a key stumbling block for the field which needs to be overcome in order to fully realise the potential of phenotypic drug disco …
Probing the mental representation of quantifiers.
Pezzelle S, Bernardi R, Piazza M. Pezzelle S, et al. Cognition. 2018 Dec;181:117-126. doi: 10.1016/j.cognition.2018.08.009. Epub 2018 Sep 1. Cognition. 2018. PMID: 30179744
Quantification of Circulating MicroRNAs by Droplet Digital PCR.
Ferracin M, Negrini M. Ferracin M, et al. Methods Mol Biol. 2018;1768:445-457. doi: 10.1007/978-1-4939-7778-9_25. Methods Mol Biol. 2018. PMID: 29717458
Sensitive and accurate methods for circulating microRNA quantification using probe-based or dye-based digital PCR technology have been developed. ...
Sensitive and accurate methods for circulating microRNA quantification using probe-based or dye-based digital PCR technology have bee …
Oral Yohimbine as a New Probe Drug to Predict CYP2D6 Activity: Results of a Fixed-Sequence Phase I Trial.
Vay M, Meyer MJ, Blank A, Skopp G, Rose P, Tzvetkov MV, Mikus G. Vay M, et al. Clin Pharmacokinet. 2020 Jul;59(7):927-939. doi: 10.1007/s40262-020-00862-6. Clin Pharmacokinet. 2020. PMID: 32060866 Free PMC article. Clinical Trial.
CONCLUSIONS: The pharmacokinetics of yohimbine were highly correlated with CYP2D6, which was further supported by the clearance inhibition caused by the CYP2D6 inhibitor paroxetine. With these data, yohimbine is proposed to be a suitable probe drug to predict CYP2D6 activi …
CONCLUSIONS: The pharmacokinetics of yohimbine were highly correlated with CYP2D6, which was further supported by the clearance inhibition c …
Guidelines for the Synthesis of Small-Molecule Irreversible Probes Targeting G Protein-Coupled Receptors.
Jörg M, Scammells PJ. Jörg M, et al. ChemMedChem. 2016 Jul 19;11(14):1488-98. doi: 10.1002/cmdc.201600066. Epub 2016 Jun 27. ChemMedChem. 2016. PMID: 27347648 Review.
Irreversible probes have been proven to be useful pharmacological tools in the study of structural and functional features in drug receptor pharmacology. They have been demonstrated to be particularly valuable for the isolation and purification of receptors. Furthermore, i …
Irreversible probes have been proven to be useful pharmacological tools in the study of structural and functional features in drug re …
Assessment of Gut Barrier Integrity in Mice Using Fluorescein-Isothiocyanate-Labeled Dextran.
Gerkins C, Hajjar R, Oliero M, Santos MM. Gerkins C, et al. J Vis Exp. 2022 Nov 18;(189). doi: 10.3791/64710. J Vis Exp. 2022. PMID: 36468715
This technique aims to assess residual fluorescence in the abdominal cavity and the hepatic uptake, which is suggestive of portal migration of the fluorescent probe. Blood and stool samples are collected 4 h after oral gavage, and the mice are sacrificed. ...
This technique aims to assess residual fluorescence in the abdominal cavity and the hepatic uptake, which is suggestive of portal migration …
A membrane-activatable near-infrared fluorescent probe with ultra-photostability for mitochondrial membrane potentials.
Ren W, Ji A, Karmach O, Carter DG, Martins-Green MM, Ai HW. Ren W, et al. Analyst. 2016 Jun 7;141(12):3679-85. doi: 10.1039/c5an01860a. Analyst. 2016. PMID: 26535416
Herein, we report a photostable near-infrared (NIR) fluorescent dye for monitoring MMP. This new probe, named NIMAP, is non-fluorescent in aqueous solution and can be activated by cell membranes, providing high fluorescence contrast and low background fluorescence. ...Due …
Herein, we report a photostable near-infrared (NIR) fluorescent dye for monitoring MMP. This new probe, named NIMAP, is non-fluoresce …
21 results