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The therapeutic effectiveness of 177Lu-lilotomab in B-cell non-Hodgkin lymphoma involves modulation of G2/M cell cycle arrest.
Pichard A, Marcatili S, Karam J, Constanzo J, Ladjohounlou R, Courteau A, Jarlier M, Bonnefoy N, Patzke S, Stenberg V, Coopman P, Cartron G, Navarro-Teulon I, Repetto-Llamazares A, Heyerdahl H, Dahle J, Bardiès M, Pouget JP. Pichard A, et al. Leukemia. 2020 May;34(5):1315-1328. doi: 10.1038/s41375-019-0677-4. Epub 2019 Dec 13. Leukemia. 2020. PMID: 31836849 Free PMC article.
Clonogenic and proliferation assays showed that DOHH2 cells were highly sensitive to (177)Lu-lilotomab, while Ramos cells were the least sensitive, and U2932 (DLBCL), OCI-Ly8, and Rec-1 (mantle cell lymphoma) cells displayed intermediate sensitivity. The strong (177)Lu-lil …
Clonogenic and proliferation assays showed that DOHH2 cells were highly sensitive to (177)Lu-lilotomab, while Ramos cells were the least sen …
FDG positron emission tomography/computed tomography scan may identify mantle cell lymphoma patients with unusually favorable outcome.
Karam M, Ata A, Irish K, Feustel PJ, Mottaghy FM, Stroobants SG, Verhoef GE, Chundru S, Douglas-Nikitin V, Oliver Wong CY, Brepoels LM. Karam M, et al. Nucl Med Commun. 2009 Oct;30(10):770-8. doi: 10.1097/MNM.0b013e32832e0c13. Nucl Med Commun. 2009. PMID: 19657307
OBJECTIVE: Patients diagnosed with mantle cell lymphoma (MCL) have generally poor prognosis, but a minority have a longer survival. ...
OBJECTIVE: Patients diagnosed with mantle cell lymphoma (MCL) have generally poor prognosis, but a minority have a longer survival. . …