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Year Number of Results
1989 1
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2012 8
2013 7
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2017 9
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130 results

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Page 1
Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone.
Cui Z, Crane J, Xie H, Jin X, Zhen G, Li C, Xie L, Wang L, Bian Q, Qiu T, Wan M, Xie M, Ding S, Yu B, Cao X. Cui Z, et al. Ann Rheum Dis. 2016 Sep;75(9):1714-21. doi: 10.1136/annrheumdis-2015-207923. Epub 2015 Oct 15. Ann Rheum Dis. 2016. PMID: 26470720 Free PMC article.
Articular cartilage degeneration was graded using the Osteoarthritis Research Society International (OARSI)-modified Mankin criteria. Immunostaining, flow cytometry, RT-PCR and western blot analyses were conducted to detect relative protein and RNA expression. ...
Articular cartilage degeneration was graded using the Osteoarthritis Research Society International (OARSI)-modified Mankin criteria. …
Injectable Temperature-Sensitive Hydrogel Loaded with IL-36Ra for the Relief of Osteoarthritis.
Yi YH, Chen G, Gong S, Han LZ, Gong TL, Wang YX, Xu WH, Jin X. Yi YH, et al. ACS Biomater Sci Eng. 2023 Mar 13;9(3):1672-1681. doi: 10.1021/acsbiomaterials.2c01144. Epub 2023 Feb 16. ACS Biomater Sci Eng. 2023. PMID: 36796355
Meanwhile, the joints of mice in the IL-36Ra@Gel group had the most intact cartilage surface, the smallest thickness of cartilage erosion, and the lowest OARSI and Mankins score among all groups. Consequently, the combination of IL-36Ra and PLGA-PLEG-PLGA temperature-sensi …
Meanwhile, the joints of mice in the IL-36Ra@Gel group had the most intact cartilage surface, the smallest thickness of cartilage erosion, a …
Pathological, Morphometric and Correlation Analysis of the Modified Mankin Score, Tidemark Roughness and Calcified Cartilage Thickness in Rat Knee Osteoarthritis after Extracorporeal Shockwave Therapy.
Cheng JH, Chou WY, Wang CJ, Siu KK, Peng JM, Wu YN, Lee MS, Huang CY, Ko JY, Jhan SW. Cheng JH, et al. Int J Med Sci. 2022 Jan 1;19(2):242-256. doi: 10.7150/ijms.67741. eCollection 2022. Int J Med Sci. 2022. PMID: 35165510 Free PMC article.
The paper displayed the pathological changes and relationships of the modified Mankin score, tidemark roughness and calcified cartilage (CC) thickness by extracorporeal shockwave therapy (ESWT) (0.25 mJ/ mm(2) with 800 impulses) on different positions of the medial and lat …
The paper displayed the pathological changes and relationships of the modified Mankin score, tidemark roughness and calcified cartila …
Non-weight-bearing exercise attenuates papain-induced knee osteoarthritis in rats via the TLR4/MyD88/NF-κB signaling pathway.
Wang K, Zhang X, Li X, Li D, Shan Z, Yao C. Wang K, et al. J Orthop Surg Res. 2023 Sep 18;18(1):695. doi: 10.1186/s13018-023-04201-w. J Orthop Surg Res. 2023. PMID: 37718444 Free PMC article.
METHODS: In this study, a papain-induced KOA model was constructed, and the pathological changes in cartilage tissue were observed by hematoxylin and eosin (H&E) staining and scored according to the Mankin scoring principle. The serum levels of interleukin (IL)-1beta, …
METHODS: In this study, a papain-induced KOA model was constructed, and the pathological changes in cartilage tissue were observed by hemato …
[Intervention effect of Youguiwan on rats with knee osteoarthritis and its mechanism].
Yan CL, An FY, Wang YF, Jin H, Zhao CB, Wang TX, Deng J, Zhang LL. Yan CL, et al. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2020 Sep;36(5):511-516. doi: 10.12047/j.cjap.5988.2020.109. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2020. PMID: 33629568 Free article. Chinese.
After intervening, articular cartilage of rats were obtained, the pathological changes were observed by using HE staining method, and Mankin score was evaluated. The expressions of OGN, ON and FBN2 in articular cartilage were detected by immunohistochemistry. The expressio …
After intervening, articular cartilage of rats were obtained, the pathological changes were observed by using HE staining method, and Man …
Clock gene Per1 regulates rat temporomandibular osteoarthritis through NF-κB pathway: an in vitro and in vivo study.
Wei JM, Tu SQ, Wang YX, Zhang S, Feng Y, Ai H, Chen Z. Wei JM, et al. J Orthop Surg Res. 2023 Oct 31;18(1):817. doi: 10.1186/s13018-023-04301-7. J Orthop Surg Res. 2023. PMID: 37907921 Free PMC article.
The thickness of cartilage in UAC group significantly reduced. The modified Mankin scores and the expression of PER1, MMP13 and P65 in cartilage of UAC group significantly increased compared with Sham group. ...
The thickness of cartilage in UAC group significantly reduced. The modified Mankin scores and the expression of PER1, MMP13 and P65 i …
[Repair impact of vibration exercise with different frequencies on articular cartilage of rats with early knee osteoarthritis and its JNK/NF-κB, SOX9 mechanisms].
Wang ZB, Wang L, Liu QQ, Yang YH, Liu P, Li SL, Yao CF. Wang ZB, et al. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2022 Jan;38(1):41-46. doi: 10.12047/j.cjap.6204.2022.008. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2022. PMID: 35634668 Free article. Chinese.
Results: Compared with the NC group,the Mankin score in other groups was significantly higher (P<0.01). Compared with the MC group,the Mankin score of each vibration group was significantly lower(P<0.05),the mRNA and protein expressions of JNK and NF-kappaB p6 …
Results: Compared with the NC group,the Mankin score in other groups was significantly higher (P<0.01). Compared with the MC group …
Clinical-Grade Human Embryonic Stem Cell-Derived Mesenchymal Stromal Cells Ameliorate the Progression of Osteoarthritis in a Rat Model.
Xing D, Wang K, Wu J, Zhao Y, Liu W, Li JJ, Gao T, Yan D, Wang L, Hao J, Lin J. Xing D, et al. Molecules. 2021 Jan 24;26(3):604. doi: 10.3390/molecules26030604. Molecules. 2021. PMID: 33498966 Free PMC article.
At sixweeks after treatment, the groups treated with both single and repeated doses of ES-MSCs had significantly better modified Mankin scores and International Cartilage Repair Society (ICRS) macroscopic scores in the femoral condyle compared to the control group. ...Hist …
At sixweeks after treatment, the groups treated with both single and repeated doses of ES-MSCs had significantly better modified Mankin …
Intra-articular Injection of Cell-laden 3D Microcryogels Empower Low-dose Cell Therapy for Osteoarthritis in a Rat Model.
Xing D, Liu W, Wang B, Li JJ, Zhao Y, Li H, Liu A, Du Y, Lin J. Xing D, et al. Cell Transplant. 2020 Jan-Dec;29:963689720932142. doi: 10.1177/0963689720932142. Cell Transplant. 2020. PMID: 32608995 Free PMC article.
At 4 and 8 wk, the microcryogels + MSCs and high-dose free MSC groups had significantly higher International Cartilage Repair Society macroscopic scores, histological evidence of more proteoglycan deposition and less cartilage loss accompanied by a lower Mankin score, and …
At 4 and 8 wk, the microcryogels + MSCs and high-dose free MSC groups had significantly higher International Cartilage Repair Society macros …
130 results