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Subchondral bone dysplasia partly participates in prenatal dexamethasone induced-osteoarthritis susceptibility in female offspring rats.
Xiao H, Xie X, Wen Y, Tan Y, Shangguan Y, Li B, Magdalou J, Wang H, Chen L. Xiao H, et al. Bone. 2020 Apr;133:115245. doi: 10.1016/j.bone.2020.115245. Epub 2020 Jan 18. Bone. 2020. PMID: 31962170
We found that PDE led to osteoarthritis phenotypes in articular cartilage and an increase in modified Mankin's score, but reduced the cartilage thickness in female adult offspring rats, which were more evident after ovariectomy. ...
We found that PDE led to osteoarthritis phenotypes in articular cartilage and an increase in modified Mankin's score, but redu …
[Warm needling reduces oxidative damage and inflammation of cartilage in knee osteoarthritis rats].
Tan Q, Li J, Li BC, Xiang HC, Cai GW. Tan Q, et al. Zhen Ci Yan Jiu. 2022 Apr 25;47(4):321-8. doi: 10.13702/j.1000-0607.20210308. Zhen Ci Yan Jiu. 2022. PMID: 35486011 Chinese.
After 21 days of treatment, the histopathological changes of knee joint were observed by HE staining, and Mankin score was calculated to evaluate the degree of cartilage destruction. ...RESULTS: Compared with the control group, the knee joint swelling volume from the 3(rd) …
After 21 days of treatment, the histopathological changes of knee joint were observed by HE staining, and Mankin score was calculated …
Subchondral bone dysplasia mediates susceptibility to osteoarthritis in female adult offspring rats induced by prenatal caffeine exposure.
Xie X, Tan Y, Xiao H, Wen Y, Magdalou J, Chen L, Wang H. Xie X, et al. Toxicol Lett. 2020 Mar 15;321:122-130. doi: 10.1016/j.toxlet.2019.12.026. Epub 2019 Dec 23. Toxicol Lett. 2020. PMID: 31874197
The female offspring were euthanized to collect femurs at GD20, postnatal week (PW) 6, and PW28 (non-ovariectomy and ovariectomy groups) to detect osteoarthritis-like phenotype, subchondral bone mass, ossification center development, and other evidence. The results showed that PC …
The female offspring were euthanized to collect femurs at GD20, postnatal week (PW) 6, and PW28 (non-ovariectomy and ovariectomy groups) to …
A treatment combined prussian blue nanoparticles with low-intensity pulsed ultrasound alleviates cartilage damage in knee osteoarthritis by initiating PI3K/Akt/mTOR pathway.
Zuo D, Tan B, Jia G, Wu D, Yu L, Jia L. Zuo D, et al. Am J Transl Res. 2021 May 15;13(5):3987-4006. eCollection 2021. Am J Transl Res. 2021. PMID: 34149994 Free PMC article.
Articular pathological changes were observed by naked eyes, H&E, and Safranin O staining, then monitored by cartilage lesion grades and Mankin's score. Cellular ROS, apoptosis rate, and TUNEL staining of chondrocytes were fairly decreased in the PBNPs group and …
Articular pathological changes were observed by naked eyes, H&E, and Safranin O staining, then monitored by cartilage lesion grades and …
Tougu Xiaotong capsule exerts a therapeutic effect by improving knee meniscus in the early osteoarthritis rat model.
Wu G, Huang Y, Chen W, Chen J, Lu X, Liu X, Feng F, Huang M, Lin R, Li Z, Tan C. Wu G, et al. Exp Ther Med. 2020 Jun;19(6):3641-3649. doi: 10.3892/etm.2020.8624. Epub 2020 Mar 24. Exp Ther Med. 2020. PMID: 32373192 Free PMC article.
Following hematoxylin and eosin staining, the degeneration of cartilage structure was evaluated via Mankin score, the microstructure of meniscus was observed and the area of calcification in meniscus was analyzed. ...The results showed that compared with the normal group, …
Following hematoxylin and eosin staining, the degeneration of cartilage structure was evaluated via Mankin score, the microstructure …
Reconstruction of medial meniscus posterior portion deficiency in pigs with an autologous patellar tendon graft: an experimental study.
Chen Z, Li A, Shi R, Wang L, Cao Z, Mao N, Luo Z, Tan H. Chen Z, et al. J Orthop Surg Res. 2024 Apr 4;19(1):225. doi: 10.1186/s13018-024-04684-1. J Orthop Surg Res. 2024. PMID: 38576008 Free PMC article.
The tibial and femoral cartilage injuries were evaluated using the International Society for Cartilage Repair (ICRS) grade and Mankin score. Histological and immunohistochemical staining was conducted on the meniscus-tendon junction area, primary meniscus, and tendons. ... …
The tibial and femoral cartilage injuries were evaluated using the International Society for Cartilage Repair (ICRS) grade and Mankin …
Role of TGFβ Signaling in Maternal Ethanol-Induced Fetal Articular Cartilage Dysplasia and Adult Onset of Osteoarthritis in Male Rats.
Ni Q, Lu K, Li J, Tan Y, Qin J, Magdalou J, Chen L, Wang H. Ni Q, et al. Toxicol Sci. 2018 Jul 1;164(1):179-190. doi: 10.1093/toxsci/kfy080. Toxicol Sci. 2018. PMID: 29617878
After intraarticular injection of papain, histological analyses, and the Mankin score revealed increased cartilage destruction in the ethanol treatment group. ...
After intraarticular injection of papain, histological analyses, and the Mankin score revealed increased cartilage destruction in the …
Upregulation of microRNA-9-5p inhibits apoptosis of chondrocytes through downregulating Tnc in mice with osteoarthritis following tibial plateau fracture.
Chen H, Yang J, Tan Z. Chen H, et al. J Cell Physiol. 2019 Dec;234(12):23326-23336. doi: 10.1002/jcp.28900. Epub 2019 Jun 6. J Cell Physiol. 2019. PMID: 31169312
Subsequently, downregulation of miR-9-5p aggravated the pathological changes of mice, illustrated by an increase in the Mankin score. In conclusion, the present study proved that overexpression of miR-9-5p suppressed chondrocytes apoptosis and promoted cartilage remodeling …
Subsequently, downregulation of miR-9-5p aggravated the pathological changes of mice, illustrated by an increase in the Mankin score. …
17 results